The study of sirtuins in breast cancer patients before and after radiotherapy

helvacı, nazlı; YILDIZ, Oguz Galip; Kılıç, eser; Saracoglu, Hatice

doi:10.3906/sag-2012-195

The study of sirtuins in breast cancer patients before and after radiotherapy

Nazlı HELVACI, (Erciyes Üniversitesi, Sağlık Bilimleri Enstitüsü, Kayseri, Türkiye)

Hatice SARAÇOĞLU, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Oğuz Galip YILDIZ, (Erciyes Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Kayseri, Türkiye)

Eser KILIÇ (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2021 Cilt: 51 Sayı: 3 Sayfa Aralığı: 1354 - 1359 Metin Dili: İngilizce DOI: 10.3906/sag-2012-195 İndeks Tarihi: 19-01-2022

The study of sirtuins in breast cancer patients before and after radiotherapy

Öz:

Background/aim: Targeting the new and unique proteins is an important medical strategy for treating breast cancer. It is quite important to find out proteins that have a role in the development of cancer. Sirtuins (SIRT) are well related in different physiological activities and connected with cancer. We aimed to determine the effect of radiotherapy on SIRT1 and SIRT2, which have not been yet been clarified as a tumor suppressor or promoter.Materials and methods: Twenty-two women with nonmetastatic breast cancer enrolled in the study. Blood samples were taken before and after radiotherapy, soluble SIRT1 and SIRT2 levels were determined with ELISA kits.Results: There was no difference in SIRT1 levels before and after radiotherapy (p = 0.548). SIRT2 levels were significantly found to be decreased after radiotherapy (p = 0.042). There was a strong and positive correlation before radiotherapy (p < 0.001), and a moderate and positive correlation after radiotherapy (p = 0.007) between SIRT1 and SIRT2.Conclusion: These results suggest that SIRT2 may provide a new strategy for follow-up of breast cancer treatment. Additionally, by emphasizing the importance of SIRT2 in breast cancer, it opens ways to provide grounds for the development of the next generation of SIRT2-specific radiotracers. Finally, the most important thing, in fact, the positive correlation between SIRT1 and SIRT2 both before and after radiotherapy, appears to be clear evidence suggesting more oncogenic roles of sirtuins.Key words: Sirtuin, breast cancer, radiotherapy

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	helvacı n, Saracoglu H, YILDIZ O, Kılıç e (2021). The study of sirtuins in breast cancer patients before and after radiotherapy. , 1354 - 1359. 10.3906/sag-2012-195
Chicago	helvacı nazlı,Saracoglu Hatice,YILDIZ Oguz Galip,Kılıç eser The study of sirtuins in breast cancer patients before and after radiotherapy. (2021): 1354 - 1359. 10.3906/sag-2012-195
MLA	helvacı nazlı,Saracoglu Hatice,YILDIZ Oguz Galip,Kılıç eser The study of sirtuins in breast cancer patients before and after radiotherapy. , 2021, ss.1354 - 1359. 10.3906/sag-2012-195
AMA	helvacı n,Saracoglu H,YILDIZ O,Kılıç e The study of sirtuins in breast cancer patients before and after radiotherapy. . 2021; 1354 - 1359. 10.3906/sag-2012-195
Vancouver	helvacı n,Saracoglu H,YILDIZ O,Kılıç e The study of sirtuins in breast cancer patients before and after radiotherapy. . 2021; 1354 - 1359. 10.3906/sag-2012-195
IEEE	helvacı n,Saracoglu H,YILDIZ O,Kılıç e "The study of sirtuins in breast cancer patients before and after radiotherapy." , ss.1354 - 1359, 2021. 10.3906/sag-2012-195
ISNAD	helvacı, nazlı vd. "The study of sirtuins in breast cancer patients before and after radiotherapy". (2021), 1354-1359. https://doi.org/10.3906/sag-2012-195

APA	helvacı n, Saracoglu H, YILDIZ O, Kılıç e (2021). The study of sirtuins in breast cancer patients before and after radiotherapy. Turkish Journal of Medical Sciences, 51(3), 1354 - 1359. 10.3906/sag-2012-195
Chicago	helvacı nazlı,Saracoglu Hatice,YILDIZ Oguz Galip,Kılıç eser The study of sirtuins in breast cancer patients before and after radiotherapy. Turkish Journal of Medical Sciences 51, no.3 (2021): 1354 - 1359. 10.3906/sag-2012-195
MLA	helvacı nazlı,Saracoglu Hatice,YILDIZ Oguz Galip,Kılıç eser The study of sirtuins in breast cancer patients before and after radiotherapy. Turkish Journal of Medical Sciences, vol.51, no.3, 2021, ss.1354 - 1359. 10.3906/sag-2012-195
AMA	helvacı n,Saracoglu H,YILDIZ O,Kılıç e The study of sirtuins in breast cancer patients before and after radiotherapy. Turkish Journal of Medical Sciences. 2021; 51(3): 1354 - 1359. 10.3906/sag-2012-195
Vancouver	helvacı n,Saracoglu H,YILDIZ O,Kılıç e The study of sirtuins in breast cancer patients before and after radiotherapy. Turkish Journal of Medical Sciences. 2021; 51(3): 1354 - 1359. 10.3906/sag-2012-195
IEEE	helvacı n,Saracoglu H,YILDIZ O,Kılıç e "The study of sirtuins in breast cancer patients before and after radiotherapy." Turkish Journal of Medical Sciences, 51, ss.1354 - 1359, 2021. 10.3906/sag-2012-195
ISNAD	helvacı, nazlı vd. "The study of sirtuins in breast cancer patients before and after radiotherapy". Turkish Journal of Medical Sciences 51/3 (2021), 1354-1359. https://doi.org/10.3906/sag-2012-195