Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer

Er, Besir; yenice, engin; Erten, Fusun; Sahin, Kazim; Defo Deeh, Patrick Brice; Oner, Pinar; Orhan, Cemal

doi:10.3906/sag-2007-254

Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer

Füsun ERTEN, (Fırat Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Elazığ, Türkiye)

Engin YENİCE, (Ankara Üniversitesi, Ziraat Fakültesi, Hayvan Besleme Bölümü, Ankara, Türkiye)

Cemal ORHAN, (Fırat Üniversitesi, Veteriner Fakültesi, Hayvan Besleme Anabilim Dalı, Elazığ, Türkiye)

Beşir ER, (Fırat Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Elazığ, Türkiye)

Pınar ÖNER, (Eğitim ve Araştırma Hastanesi, Mikrobiyoloji Anabilim Dalı, Elazığ, Türkiye)

Patrick Brice DEFO DEEH, (Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon)

KAZİM ŞAHİN (Fırat Üniversitesi, Veteriner Fakültesi, Hayvan Besleme Anabilim Dalı, Elazığ, Türkiye)

Turkish Journal of Medical Sciences

7 0

Yıl: 2021 Cilt: 51 Sayı: 3 Sayfa Aralığı: 1465 - 1471 Metin Dili: İngilizce DOI: 10.3906/sag-2007-254 İndeks Tarihi: 19-01-2022

Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer

Öz:

Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer. Materials and methods: A total of 300 laying hens were distributed into three groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg or 800 mg of genistein/kg of diet, respectively. Results: Genistein modulated the inflammatory biomarkers by decreasing serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL6), interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF) compared with control (p < 0.001). Moreover, it upregulated insulin receptor substrate-1 (p-IRS-1) and protein kinase B (p-AKT), but downregulated GSK-3α and β after treatment. It acts in a dose-dependent manner. Conclusion: Genistein exhibited an anticancer effect by reducing proinflammatory biomarkers levels and inhibiting GSK-3 expression in the ovaries of old laying hens. It is a potential candidate in the chemoprevention and/or treatment of ovarian cancer.Key words: Genistein, GSK-3, IL-6, TNF-α, laying hens, ovarian cancer

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Erten F, yenice e, Orhan C, Er B, Oner P, Defo Deeh P, Sahin K (2021). Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. , 1465 - 1471. 10.3906/sag-2007-254
Chicago	Erten Fusun,yenice engin,Orhan Cemal,Er Besir,Oner Pinar,Defo Deeh Patrick Brice,Sahin Kazim Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. (2021): 1465 - 1471. 10.3906/sag-2007-254
MLA	Erten Fusun,yenice engin,Orhan Cemal,Er Besir,Oner Pinar,Defo Deeh Patrick Brice,Sahin Kazim Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. , 2021, ss.1465 - 1471. 10.3906/sag-2007-254
AMA	Erten F,yenice e,Orhan C,Er B,Oner P,Defo Deeh P,Sahin K Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. . 2021; 1465 - 1471. 10.3906/sag-2007-254
Vancouver	Erten F,yenice e,Orhan C,Er B,Oner P,Defo Deeh P,Sahin K Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. . 2021; 1465 - 1471. 10.3906/sag-2007-254
IEEE	Erten F,yenice e,Orhan C,Er B,Oner P,Defo Deeh P,Sahin K "Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer." , ss.1465 - 1471, 2021. 10.3906/sag-2007-254
ISNAD	Erten, Fusun vd. "Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer". (2021), 1465-1471. https://doi.org/10.3906/sag-2007-254

APA	Erten F, yenice e, Orhan C, Er B, Oner P, Defo Deeh P, Sahin K (2021). Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. Turkish Journal of Medical Sciences, 51(3), 1465 - 1471. 10.3906/sag-2007-254
Chicago	Erten Fusun,yenice engin,Orhan Cemal,Er Besir,Oner Pinar,Defo Deeh Patrick Brice,Sahin Kazim Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. Turkish Journal of Medical Sciences 51, no.3 (2021): 1465 - 1471. 10.3906/sag-2007-254
MLA	Erten Fusun,yenice engin,Orhan Cemal,Er Besir,Oner Pinar,Defo Deeh Patrick Brice,Sahin Kazim Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. Turkish Journal of Medical Sciences, vol.51, no.3, 2021, ss.1465 - 1471. 10.3906/sag-2007-254
AMA	Erten F,yenice e,Orhan C,Er B,Oner P,Defo Deeh P,Sahin K Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. Turkish Journal of Medical Sciences. 2021; 51(3): 1465 - 1471. 10.3906/sag-2007-254
Vancouver	Erten F,yenice e,Orhan C,Er B,Oner P,Defo Deeh P,Sahin K Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer. Turkish Journal of Medical Sciences. 2021; 51(3): 1465 - 1471. 10.3906/sag-2007-254
IEEE	Erten F,yenice e,Orhan C,Er B,Oner P,Defo Deeh P,Sahin K "Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer." Turkish Journal of Medical Sciences, 51, ss.1465 - 1471, 2021. 10.3906/sag-2007-254
ISNAD	Erten, Fusun vd. "Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer". Turkish Journal of Medical Sciences 51/3 (2021), 1465-1471. https://doi.org/10.3906/sag-2007-254