The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease

Doğan Ekici, Asiye Işın; Uysal, Mujdat; KUCUKGERGIN, CANAN; Aydın, Abdurrahman Fatih; Dogru-Abbasoglu, Semra; BINGÜL, ILKNUR

doi:10.3906/sag-2007-289

The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease

İlknur BİNGÜL, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Abdurrahman Fatih AYDIN, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Canan KÜÇÜKGERGİN, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Işın DOĞAN EKİCİ, (Acıbadem Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye)

Semra DOĞRU ABBASOĞLU, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Müjdat UYSAL (Girilmemişş)

Turkish Journal of Medical Sciences

7 1

Yıl: 2021 Cilt: 51 Sayı: 3 Sayfa Aralığı: 1500 - 1511 Metin Dili: İngilizce DOI: 10.3906/sag-2007-289 İndeks Tarihi: 20-01-2022

The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease

Öz:

Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. Insulin resistance (IR), oxidative stress parameters, AGEs, triglyceride (TG), and hydroxyproline (Hyp) levels together with histopathology were investigated in the liver. Results: 1,25(OH)2 D3decreased hepatic reactive oxygen species, lipid and protein oxidation products together with histopathological improvements in HFr- and EtOH-treated rats. 1,25(OH)2 D3 treatment was observed to decrease significantly serum and hepatic AGEs in HFr group, and hepatic AGEs in EtOH group. Conclusion: Our results clearly show that 1,25(OH)2 D3treatment may be useful in the alleviation of hepatic lesions by decreasing glycooxidant stress in both NAFLD and ALD models created by HFr- and EtOH-treated rats, respectively.Key words: Vitamin D, fructose, ethanol, oxidative stress, glycation end products

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BINGÜL I, Aydın A, KUCUKGERGIN C, Doğan Ekici A, Dogru-Abbasoglu S, Uysal M (2021). The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. , 1500 - 1511. 10.3906/sag-2007-289
Chicago	BINGÜL ILKNUR,Aydın Abdurrahman Fatih,KUCUKGERGIN CANAN,Doğan Ekici Asiye Işın,Dogru-Abbasoglu Semra,Uysal Mujdat The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. (2021): 1500 - 1511. 10.3906/sag-2007-289
MLA	BINGÜL ILKNUR,Aydın Abdurrahman Fatih,KUCUKGERGIN CANAN,Doğan Ekici Asiye Işın,Dogru-Abbasoglu Semra,Uysal Mujdat The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. , 2021, ss.1500 - 1511. 10.3906/sag-2007-289
AMA	BINGÜL I,Aydın A,KUCUKGERGIN C,Doğan Ekici A,Dogru-Abbasoglu S,Uysal M The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. . 2021; 1500 - 1511. 10.3906/sag-2007-289
Vancouver	BINGÜL I,Aydın A,KUCUKGERGIN C,Doğan Ekici A,Dogru-Abbasoglu S,Uysal M The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. . 2021; 1500 - 1511. 10.3906/sag-2007-289
IEEE	BINGÜL I,Aydın A,KUCUKGERGIN C,Doğan Ekici A,Dogru-Abbasoglu S,Uysal M "The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease." , ss.1500 - 1511, 2021. 10.3906/sag-2007-289
ISNAD	BINGÜL, ILKNUR vd. "The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease". (2021), 1500-1511. https://doi.org/10.3906/sag-2007-289

APA	BINGÜL I, Aydın A, KUCUKGERGIN C, Doğan Ekici A, Dogru-Abbasoglu S, Uysal M (2021). The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. Turkish Journal of Medical Sciences, 51(3), 1500 - 1511. 10.3906/sag-2007-289
Chicago	BINGÜL ILKNUR,Aydın Abdurrahman Fatih,KUCUKGERGIN CANAN,Doğan Ekici Asiye Işın,Dogru-Abbasoglu Semra,Uysal Mujdat The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. Turkish Journal of Medical Sciences 51, no.3 (2021): 1500 - 1511. 10.3906/sag-2007-289
MLA	BINGÜL ILKNUR,Aydın Abdurrahman Fatih,KUCUKGERGIN CANAN,Doğan Ekici Asiye Işın,Dogru-Abbasoglu Semra,Uysal Mujdat The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. Turkish Journal of Medical Sciences, vol.51, no.3, 2021, ss.1500 - 1511. 10.3906/sag-2007-289
AMA	BINGÜL I,Aydın A,KUCUKGERGIN C,Doğan Ekici A,Dogru-Abbasoglu S,Uysal M The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. Turkish Journal of Medical Sciences. 2021; 51(3): 1500 - 1511. 10.3906/sag-2007-289
Vancouver	BINGÜL I,Aydın A,KUCUKGERGIN C,Doğan Ekici A,Dogru-Abbasoglu S,Uysal M The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease. Turkish Journal of Medical Sciences. 2021; 51(3): 1500 - 1511. 10.3906/sag-2007-289
IEEE	BINGÜL I,Aydın A,KUCUKGERGIN C,Doğan Ekici A,Dogru-Abbasoglu S,Uysal M "The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease." Turkish Journal of Medical Sciences, 51, ss.1500 - 1511, 2021. 10.3906/sag-2007-289
ISNAD	BINGÜL, ILKNUR vd. "The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress,and advanced glycation end products in experimental nonalcoholicand alcoholic- fatty liver disease". Turkish Journal of Medical Sciences 51/3 (2021), 1500-1511. https://doi.org/10.3906/sag-2007-289