TY  - JOUR
TI  - Effect of betulinic acid administration on TLR-9/NF-κB /IL-18 levels in experimental liver injury
AB  - Background/aim: Acetaminophen (APAP), used in the composition of thousands of preparations, is the most commonly used analgesic and antipyretic drug. The present study aimed to investigate the potential protective effects of the betulinic acid (BA) treatment through an APAP-induced hepatotoxicity rat model, using inflammatory, biochemical, and histopathological parameters. Materials and methods: The study consisted of four groups: control group, APAP group, BA group, and APAP+BA group. Experimental studies continued for fifteen days. Serum samples were analysed for glucose, total cholesterol (TChol), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), aspartate amino transferase (AST), malondialdehyde (MDA), toll-like receptor-9 (TLR-9), nuclear factor kappa B (NF-κB), and interleukin-18 (IL-18). Results: TLR9, IL-18, NF-κB, and MDA levels increased significantly in liver injury groups. These increases considerably decreased by the BA treatment. All groups showed immunopositivity for 8-hydroxy-2’–deoxyguanosine (8-OHdG) and interleukin (IL-1β) in the hepatocytes, inflammatory cells, and epithelial cells of bile ducts. Conclusion: BA can be used as an effective agent in the prevention and treatment of acute liver diseases due to its inhibitory properties in multiple pathways and its potent antioxidant effects.Key words: Acetaminophen, betulinic acid, interleukin-18, nuclear factor kappa B, toll-like receptor-9
AU  - Dokumacioglu, Eda
AU  - Yenice, Güler
AU  - TERIM KAPAKIN, Kübra Asena
AU  - BOLAT, ISMAIL
AU  - Mokhtare, Behzad
AU  - Hayirli, Armagan
AU  - Iskender, Hatice
DO  - 10.3906/sag-2004-184
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 3
SN  - 1300-0144
SP  - 1543
EP  - 1552
DB  - TRDizin
UR  - http://search/yayin/detay/483313
ER  -