TY  - JOUR
TI  - The effect of placental angiogenic and anti-angiogenic factors on pregnancy outcome in patients with early onset preeclampsia
AB  - Objective: The aim was to evaluate the possible effects of anti-angiogenic factors including soluble endoglin (sEng), placental growth factor (Pgf), and soluble fms-like tyrosine kinase 1 (sFlt-1) in both normotensive pregnant patients and preeclampsia (PE) patients. Material and Methods: The study was carried out at the Departments of Gynecology and Obstetrics and Biochemistry of Yozgat Bozok University Training and Research Hospital. Eighteen women with PE who were pregnant for at least 20 weeks comprised the study group. The control group consisted of 33 pregnant women with no complications and with similar demographic features. In the study, laboratory parameters, demographic characteristics, sEng, sFlt-1, and Pgf levels, delivery type, APGAR scores of the infants, and birthweight were determined and a comparison was made between the groups. Results: It was found that the sEng level was significantly lower in the PE group compared to the control group (p<0.05). In addition, the Pgf, birthweight, and 1st and 5th-minute APGAR scores were significantly lower in the PE group compared to the control group (p<0.05). Conclusion: The decrease in Pgf may have an effect on the pathogenesis of PE and can be utilized for the determination of PE. (J Turk Ger Gynecol Assoc 2021; 22: 212-6)
AU  - Yalvaç, Ethem Serdar
AU  - Kara, Mustafa
AU  - Demir çaltekin, Melike
AU  - Aydoğan kırmızı, Demet
AU  - Baser, Emre
AU  - Onat, Taylan
AU  - Ercan, Müjgan
DO  - 10.4274/jtgga.galenos.2021.2020.0173
PY  - 2021
JO  - Journal of the Turkish-German Gynecological Association
VL  - 22
IS  - 3
SN  - 1309-0399
SP  - 63
EP  - 66
DB  - TRDizin
UR  - http://search/yayin/detay/483347
ER  -