TY  - JOUR
TI  - Dopamine transporter SPECT imaging in Parkinson’s disease and parkinsonian disorders
AB  - Abstract: The dopamine transporter (DAT) imaging provides an objective tool for the assessment of dopaminergic function of presynaptic terminals which is valuable for the differential diagnosis of parkinsonian disorders related to a striatal dopaminergic deficiency from movement disorders not related a striatal dopaminergic deficiency. DAT imaging with single-photon emission computed tomography (SPECT) can be used to confirm or exclude a diagnosis of dopamine deficient parkinsonism in cases where the diagnosis is unclear. It can also detect the dopaminergic dysfunction in presymptomatic subjects at risk for Parkinson’s disease (PD) since the reduced radiotracer binding to DATs in striatum is already present in the prodromal stage of PD. This review covers the rationale of using DAT SPECT imaging in the diagnosis of PD and other parkinsonian disorders, specifically focusing on the practical aspects of imaging and routine clinical indications.Key words: Dopamine transporter, 123I-ioflupane, SPECT, Parkinson’s disease, parkinsonian disorders
AU  - Atay, Lütfiye Özlem
AU  - AKDEMİR, Ümit
AU  - BORA TOKCAER, Ayse
DO  - 10.3906/sag-2008-253
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 2
SN  - 1300-0144
SP  - 400
EP  - 410
DB  - TRDizin
UR  - http://search/yayin/detay/483538
ER  -