A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity

Kalyoncu, Ali Fuat; KARAKAYA, GÜL; Damadoglu, Ebru; OZTURK AKTAS, OZGE

doi:10.3906/sag-2005-312

A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity

Ebru ÇELEBİOĞLU, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Ankara, Türkiye)

Özge ÖZTÜRK AKTAŞ, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Ankara, Türkiye)

Gül KARAKAYA, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Ankara, Türkiye)

Ali Fuat KALYONCU (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

7 2

Yıl: 2021 Cilt: 51 Sayı: 2 Sayfa Aralığı: 604 - 609 Metin Dili: İngilizce DOI: 10.3906/sag-2005-312 İndeks Tarihi: 21-01-2022

A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity

Öz:

Background/aim: Drug provocation tests (DPTs) are the gold standard method performed at the end of a stepwise approach in a drug allergy workup. Drug provocation tests are administered as a single drug on a test day. Testing more than one drug in a day is a feasible option and could be a safe and time- and manpower-saving procedure in well-selected patients. The aim of the present study was to investigate the efficacy and safety of performing a DPT with two or three alternative drugs in one test day (Hacettepe method). Materials and methods: Adult patients who were admitted with drug hypersensitivity between August 2010 and December 2016 and underwent DPTs with the described method were included. The method was based on performing DPTs with two or three different, alternative drugs on the same test day. Data was obtained from standard drug provocation test forms and from patient files. Results: A total of 1448 DPTs were performed by the Hacettepe method in 1131 patients. The reaction rate was 5.45% (n = 79), and none of the reactions were severe. The Hacettepe method saved 19.95 DPTs per month which was a considerable time savings. Conclusion: In cases of proven drug hypersensitivity reactions, performing a drug provocation test with a combination of two or three different, alternative drugs instead of one saved time and manpower and was a safe procedure. We recommend implementing this method in drug allergy workups.Key words: Adverse drug reaction, drug allergy, drug hypersensitivity, drug provocation test, provocation test

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Damadoglu E, OZTURK AKTAS O, KARAKAYA G, Kalyoncu A (2021). A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. , 604 - 609. 10.3906/sag-2005-312
Chicago	Damadoglu Ebru,OZTURK AKTAS OZGE,KARAKAYA GÜL,Kalyoncu Ali Fuat A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. (2021): 604 - 609. 10.3906/sag-2005-312
MLA	Damadoglu Ebru,OZTURK AKTAS OZGE,KARAKAYA GÜL,Kalyoncu Ali Fuat A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. , 2021, ss.604 - 609. 10.3906/sag-2005-312
AMA	Damadoglu E,OZTURK AKTAS O,KARAKAYA G,Kalyoncu A A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. . 2021; 604 - 609. 10.3906/sag-2005-312
Vancouver	Damadoglu E,OZTURK AKTAS O,KARAKAYA G,Kalyoncu A A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. . 2021; 604 - 609. 10.3906/sag-2005-312
IEEE	Damadoglu E,OZTURK AKTAS O,KARAKAYA G,Kalyoncu A "A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity." , ss.604 - 609, 2021. 10.3906/sag-2005-312
ISNAD	Damadoglu, Ebru vd. "A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity". (2021), 604-609. https://doi.org/10.3906/sag-2005-312

APA	Damadoglu E, OZTURK AKTAS O, KARAKAYA G, Kalyoncu A (2021). A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. Turkish Journal of Medical Sciences, 51(2), 604 - 609. 10.3906/sag-2005-312
Chicago	Damadoglu Ebru,OZTURK AKTAS OZGE,KARAKAYA GÜL,Kalyoncu Ali Fuat A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. Turkish Journal of Medical Sciences 51, no.2 (2021): 604 - 609. 10.3906/sag-2005-312
MLA	Damadoglu Ebru,OZTURK AKTAS OZGE,KARAKAYA GÜL,Kalyoncu Ali Fuat A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. Turkish Journal of Medical Sciences, vol.51, no.2, 2021, ss.604 - 609. 10.3906/sag-2005-312
AMA	Damadoglu E,OZTURK AKTAS O,KARAKAYA G,Kalyoncu A A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. Turkish Journal of Medical Sciences. 2021; 51(2): 604 - 609. 10.3906/sag-2005-312
Vancouver	Damadoglu E,OZTURK AKTAS O,KARAKAYA G,Kalyoncu A A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity. Turkish Journal of Medical Sciences. 2021; 51(2): 604 - 609. 10.3906/sag-2005-312
IEEE	Damadoglu E,OZTURK AKTAS O,KARAKAYA G,Kalyoncu A "A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity." Turkish Journal of Medical Sciences, 51, ss.604 - 609, 2021. 10.3906/sag-2005-312
ISNAD	Damadoglu, Ebru vd. "A practical method of drug provocation testing to prove tolerance to alternative drugs in drug hypersensitivity". Turkish Journal of Medical Sciences 51/2 (2021), 604-609. https://doi.org/10.3906/sag-2005-312