Acute necrotizing encephalopathy of childhood: a single-center experience

Yıl: 2021 Cilt: 51 Sayı: 2 Sayfa Aralığı: 706 - 715 Metin Dili: İngilizce DOI: 10.3906/sag-2102-47 İndeks Tarihi: 21-01-2022

Acute necrotizing encephalopathy of childhood: a single-center experience

Öz:
Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 ± 1.94 years (age range 1–6.5) were included in this study. The interval range between fever and encephalopathy in patients was 1–4 days. Influenza A (3H1N1, one untyped) was detected in four patients, influenza B in three patients, and no cause was found in two patients. Major clinical findings other than febrile encephalopathy in all patients were a hemodynamic shock in seven patients, seizures in six patients, vomiting in five patients, dystonia in three patients, and flaccid paralysis in the upper extremity in one patient. Despite all our treatment approaches, including plasmapheresis, moderate to severe neurological sequelae was observed in all of our patients, who survived even with significant radiological improvement. Three patients for whom we could not perform plasmapheresis died. Conclusion: Our study revealed that thalamic involvement increased as the interval shortened, and brainstem involvement increased in patients over four years of age. The presence of persistent vomiting accompanying encephalopathy during the parainfectious period and plasmapheresis treatment being a treatment option that could prevent mortality were cautionary for our study.Key words: Febrile illness, encephalopathy, multifocal brain lesions, seizure(s), childhood
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APA aksoy e, Öztoprak Ü, ÇELİK H, ÖZDEMİR F, Ozkan M, Kayılıoğlu H, danış a, KUCUR Ö, KESİCİ S, YAZICI M, AZAPAĞASI E, YILDIZ Y, CEYLAN N, ŞENEL S, YÜKSEL D (2021). Acute necrotizing encephalopathy of childhood: a single-center experience. , 706 - 715. 10.3906/sag-2102-47
Chicago aksoy erhan,Öztoprak Ülkühan,ÇELİK Halil,ÖZDEMİR Fatih Mehmet Akif,Ozkan Mehpare,Kayılıoğlu Hülya,danış ayşegül,KUCUR Özge,KESİCİ Selman,YAZICI Mutlu Uysal,AZAPAĞASI Ebru,YILDIZ Yasemin TAŞCI,CEYLAN Nesrin,ŞENEL Saliha,YÜKSEL Deniz Acute necrotizing encephalopathy of childhood: a single-center experience. (2021): 706 - 715. 10.3906/sag-2102-47
MLA aksoy erhan,Öztoprak Ülkühan,ÇELİK Halil,ÖZDEMİR Fatih Mehmet Akif,Ozkan Mehpare,Kayılıoğlu Hülya,danış ayşegül,KUCUR Özge,KESİCİ Selman,YAZICI Mutlu Uysal,AZAPAĞASI Ebru,YILDIZ Yasemin TAŞCI,CEYLAN Nesrin,ŞENEL Saliha,YÜKSEL Deniz Acute necrotizing encephalopathy of childhood: a single-center experience. , 2021, ss.706 - 715. 10.3906/sag-2102-47
AMA aksoy e,Öztoprak Ü,ÇELİK H,ÖZDEMİR F,Ozkan M,Kayılıoğlu H,danış a,KUCUR Ö,KESİCİ S,YAZICI M,AZAPAĞASI E,YILDIZ Y,CEYLAN N,ŞENEL S,YÜKSEL D Acute necrotizing encephalopathy of childhood: a single-center experience. . 2021; 706 - 715. 10.3906/sag-2102-47
Vancouver aksoy e,Öztoprak Ü,ÇELİK H,ÖZDEMİR F,Ozkan M,Kayılıoğlu H,danış a,KUCUR Ö,KESİCİ S,YAZICI M,AZAPAĞASI E,YILDIZ Y,CEYLAN N,ŞENEL S,YÜKSEL D Acute necrotizing encephalopathy of childhood: a single-center experience. . 2021; 706 - 715. 10.3906/sag-2102-47
IEEE aksoy e,Öztoprak Ü,ÇELİK H,ÖZDEMİR F,Ozkan M,Kayılıoğlu H,danış a,KUCUR Ö,KESİCİ S,YAZICI M,AZAPAĞASI E,YILDIZ Y,CEYLAN N,ŞENEL S,YÜKSEL D "Acute necrotizing encephalopathy of childhood: a single-center experience." , ss.706 - 715, 2021. 10.3906/sag-2102-47
ISNAD aksoy, erhan vd. "Acute necrotizing encephalopathy of childhood: a single-center experience". (2021), 706-715. https://doi.org/10.3906/sag-2102-47
APA aksoy e, Öztoprak Ü, ÇELİK H, ÖZDEMİR F, Ozkan M, Kayılıoğlu H, danış a, KUCUR Ö, KESİCİ S, YAZICI M, AZAPAĞASI E, YILDIZ Y, CEYLAN N, ŞENEL S, YÜKSEL D (2021). Acute necrotizing encephalopathy of childhood: a single-center experience. Turkish Journal of Medical Sciences, 51(2), 706 - 715. 10.3906/sag-2102-47
Chicago aksoy erhan,Öztoprak Ülkühan,ÇELİK Halil,ÖZDEMİR Fatih Mehmet Akif,Ozkan Mehpare,Kayılıoğlu Hülya,danış ayşegül,KUCUR Özge,KESİCİ Selman,YAZICI Mutlu Uysal,AZAPAĞASI Ebru,YILDIZ Yasemin TAŞCI,CEYLAN Nesrin,ŞENEL Saliha,YÜKSEL Deniz Acute necrotizing encephalopathy of childhood: a single-center experience. Turkish Journal of Medical Sciences 51, no.2 (2021): 706 - 715. 10.3906/sag-2102-47
MLA aksoy erhan,Öztoprak Ülkühan,ÇELİK Halil,ÖZDEMİR Fatih Mehmet Akif,Ozkan Mehpare,Kayılıoğlu Hülya,danış ayşegül,KUCUR Özge,KESİCİ Selman,YAZICI Mutlu Uysal,AZAPAĞASI Ebru,YILDIZ Yasemin TAŞCI,CEYLAN Nesrin,ŞENEL Saliha,YÜKSEL Deniz Acute necrotizing encephalopathy of childhood: a single-center experience. Turkish Journal of Medical Sciences, vol.51, no.2, 2021, ss.706 - 715. 10.3906/sag-2102-47
AMA aksoy e,Öztoprak Ü,ÇELİK H,ÖZDEMİR F,Ozkan M,Kayılıoğlu H,danış a,KUCUR Ö,KESİCİ S,YAZICI M,AZAPAĞASI E,YILDIZ Y,CEYLAN N,ŞENEL S,YÜKSEL D Acute necrotizing encephalopathy of childhood: a single-center experience. Turkish Journal of Medical Sciences. 2021; 51(2): 706 - 715. 10.3906/sag-2102-47
Vancouver aksoy e,Öztoprak Ü,ÇELİK H,ÖZDEMİR F,Ozkan M,Kayılıoğlu H,danış a,KUCUR Ö,KESİCİ S,YAZICI M,AZAPAĞASI E,YILDIZ Y,CEYLAN N,ŞENEL S,YÜKSEL D Acute necrotizing encephalopathy of childhood: a single-center experience. Turkish Journal of Medical Sciences. 2021; 51(2): 706 - 715. 10.3906/sag-2102-47
IEEE aksoy e,Öztoprak Ü,ÇELİK H,ÖZDEMİR F,Ozkan M,Kayılıoğlu H,danış a,KUCUR Ö,KESİCİ S,YAZICI M,AZAPAĞASI E,YILDIZ Y,CEYLAN N,ŞENEL S,YÜKSEL D "Acute necrotizing encephalopathy of childhood: a single-center experience." Turkish Journal of Medical Sciences, 51, ss.706 - 715, 2021. 10.3906/sag-2102-47
ISNAD aksoy, erhan vd. "Acute necrotizing encephalopathy of childhood: a single-center experience". Turkish Journal of Medical Sciences 51/2 (2021), 706-715. https://doi.org/10.3906/sag-2102-47