Yıl: 2021 Cilt: 43 Sayı: 5 Sayfa Aralığı: 427 - 432 Metin Dili: İngilizce DOI: 10.14744/etd.2021.35920 İndeks Tarihi: 21-01-2022

Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children

Öz:
Objective: A positive relationship exists between high blood glucose levels and infection prevalence in patients with dia betes. Hyperglycemia may predispose to fungal infections. This study was conducted to compare the frequency of fungalinfections and antifungal agent resistance of culture strains in children with type 1 diabetes mellitus (T1DM) with those inhealthy controls and to assess the relationship between fungal infection and hemoglobin A1c (HbA1c) levels. Materials and Methods: The study population included 67 girls with T1DM and 63 girls without T1DM, immunodefi ciency, or chronic drug use. Blood and urine samples were collected, and genital smear sampling was performed. Sampleswere evaluated in a mycology laboratory, and fluconazole sensitivity of culture samples was determined. Results: Genital complaints were more common among patients with diabetes. Fungal agents were isolated in 55.22% ofpatients with diabetes, where Candida glabrata was the most common strain isolated (46.0%). Meanwhile, Candida albicanswas more common in the control group (40.0%). All strains were fluconazole-sensitive, as strains with native resistance wereexcepted. For serum HbA1c levels, a cutoff value of 8.9 was identified and was related to fungal growth with a reliability of80%. Patients with diabetes for more than 12 months had a higher risk of fungal infection. Conclusion: Patients with serum HbA1c levels of more than 8.9 and a diabetes duration of more than 12 months shouldbe assessed for fungal infections, and genital smear samples should be obtained periodically during follow-up.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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  • 1. Demirbilek H, Özbek MN, Baran RT. Incidence of type 1 diabetes mellitus in Turkish children from the southeastern region of the country: a regional report. J Clin Res Pediatr Endocrinol 2013; 5(2): 98–103.
  • 2. DiMeglio LA, Evans-Molina C, Oram RA. Type 1 diabetes. Lancet 2018; 391(10138): 2449–62.
  • 3. Sapra A, Bhandari P. Diabetes mellitus. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020.
  • 4. Alemzedeh R, Ali O. Diabetes mellitus in children, In: Kliegman RM, Behrman RE, Jenson HB, and Stanton BM, editors. Nelson textbook of pediatrics. 19th edition. Philedelphia: Elsevier Health Sciences; 2011.p.1968–90.
  • 5. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29 Suppl 1: S43–8.
  • 6. Allen N, Gupta A. Current diabetes technology: striving for the artificial pancreas. Diagnostics (Basel) 2019; 9(1): 31
  • 7. Akirov A, Diker-Cohen T, Masri-Iraqi H, Duskin-Bitan H, Shimon I, Gorshtein A. Outcomes of hyperglycemia in patients with and without diabetes hospitalized for infectious diseases. Diabetes Metab Res Rev 2018; 34(7): e3027.
  • 8. Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol 2008; 180(3): 1929–37.
  • 9. Soyucen E, Gulcan A, Aktuglu-Zeybek AC, Onal H, Kiykim E, Aydin A. Differences in the gut microbiota of healthy children and those with type 1 diabetes. Pediatr Int 2014; 56(3): 336–43.
  • 10. Kendirci M, Koç AN, Kurtoglu S, Keskin M, Kuyucu T. Vulvovaginal candidiasis in children and adolescents with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2004; 17(11): 1545–9.
  • 11. Bassyouni RH, Wegdan AA, Abdelmoneim A, Said W, AboElnaga F. Phospholipase and aspartyl proteinase activities of candida species causing vulvovaginal candidiasis in patients with type 2 diabetes mellitus. J Microbiol Biotechnol 2015; 25: 1734–41.
  • 12. Cuenca-Estrella M, Gomez-Lopez A, Alastruey-Izquierdo A, BernalMartinez L, Cuesta I, Buitrago MJ, et al. Comparison of the Vitek 2 antifungal susceptibility system with the clinical and laboratory standards institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) Broth Microdilution Reference Methods and with the Sensititre YeastOne and Etest techniques for in vitro detection of antifungal resistance in yeast isolates. J Clin Microbiol 2010; 48(5): 1782–6.
  • 13. Ranque S, Lachaud L, Gari-Toussaint M, Michel-Nguyen A, Mallié M, Gaudart J, et al. Interlaboratory reproducibility of Etest amphotericin B and caspofungin yeast susceptibility testing and comparison with the CLSI method. J Clin Microbiol 2012; 50(7): 2305–9.
  • 14. Goksuluk D, Korkmaz S, Zararsiz G, Karaagaoglu AE. easyROC: An interactive web-tool for ROC curve analysis using R language environment. R J 2016; 8(2): 213–30.
  • 15. Atabek ME, Akyürek N, Eklioglu BS. Frequency of vaginal candida colonization and relationship between metabolic parameters in children with type 1 diabetes mellitus. J Pediatr Adolesc Gynecol 2013; 26(5): 257–60.
  • 16. Goswami R, Dadhwal V, Tejaswi S, Datta K, Paul A, Haricharan RN, et al. Species-specific prevalence of vaginal candidiasis among patients with diabetes mellitus and its relation to their glycaemic status. J Infect 2000; 41(2): 162–6.
  • 17. Al-Mamari A, Al-Burhi M, Al-Hag S. Species-specific prevalence of vaginal candidiasis with type 1 and type 2 diabetes mellitus among women in Sana’a City. J Chem Pharm Res 2013; 5(8): 217–24.
  • 18. Willems HME, Ahmed SS, Liu J, Xu Z, Peters BM. Vulvovaginal candidiasis: A current understanding and burning questions. J Fungi (Basel) 2020; 6(1): 27.
  • 19. Grigoriou O, Baka S, Makrakis E, Hassiakos D, Kapparos G, Kouskouni E. Prevalence of clinical vaginal candidiasis in a university hospital and possible risk factors. Eur J Obstet Gynecol Reprod Biol 2006; 126(1): 121–5.
  • 20. Mirmirani P, Carpenter DM. Skin disorders associated with obesity in children and adolescents: a population-based study. Pediatr Dermatol 2014; 31(2): 183–90.
  • 21. Payne KD, Hall RG. Dosing of antifungal agents in obese people. Expert Rev Anti Infect Ther 2016; 14(2): 257–67.
  • 22. Alobaid AS, Wallis SC, Jarrett P, Starr T, Stuart J, Lassig-Smith M, et al. Effect of obesity on the population Pharmacokinetics of Fluconazole in critically Ill patients. Antimicrob Agents Chemother 2016; 60(11): 6550–7.
  • 23. Nyirjesy P, Sobel JD. Genital mycotic infections in patients with diabetes. Postgrad Med 2013; 125(3): 33–46
APA EMEKLİOĞLU B, Çakır N, CAKIR I, Kendirci M, KOC A (2021). Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. , 427 - 432. 10.14744/etd.2021.35920
Chicago EMEKLİOĞLU Burcu,Çakır Nuri,CAKIR Isil,Kendirci Mustafa,KOC A. Nedret Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. (2021): 427 - 432. 10.14744/etd.2021.35920
MLA EMEKLİOĞLU Burcu,Çakır Nuri,CAKIR Isil,Kendirci Mustafa,KOC A. Nedret Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. , 2021, ss.427 - 432. 10.14744/etd.2021.35920
AMA EMEKLİOĞLU B,Çakır N,CAKIR I,Kendirci M,KOC A Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. . 2021; 427 - 432. 10.14744/etd.2021.35920
Vancouver EMEKLİOĞLU B,Çakır N,CAKIR I,Kendirci M,KOC A Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. . 2021; 427 - 432. 10.14744/etd.2021.35920
IEEE EMEKLİOĞLU B,Çakır N,CAKIR I,Kendirci M,KOC A "Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children." , ss.427 - 432, 2021. 10.14744/etd.2021.35920
ISNAD EMEKLİOĞLU, Burcu vd. "Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children". (2021), 427-432. https://doi.org/10.14744/etd.2021.35920
APA EMEKLİOĞLU B, Çakır N, CAKIR I, Kendirci M, KOC A (2021). Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. Erciyes Medical Journal, 43(5), 427 - 432. 10.14744/etd.2021.35920
Chicago EMEKLİOĞLU Burcu,Çakır Nuri,CAKIR Isil,Kendirci Mustafa,KOC A. Nedret Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. Erciyes Medical Journal 43, no.5 (2021): 427 - 432. 10.14744/etd.2021.35920
MLA EMEKLİOĞLU Burcu,Çakır Nuri,CAKIR Isil,Kendirci Mustafa,KOC A. Nedret Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. Erciyes Medical Journal, vol.43, no.5, 2021, ss.427 - 432. 10.14744/etd.2021.35920
AMA EMEKLİOĞLU B,Çakır N,CAKIR I,Kendirci M,KOC A Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. Erciyes Medical Journal. 2021; 43(5): 427 - 432. 10.14744/etd.2021.35920
Vancouver EMEKLİOĞLU B,Çakır N,CAKIR I,Kendirci M,KOC A Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children. Erciyes Medical Journal. 2021; 43(5): 427 - 432. 10.14744/etd.2021.35920
IEEE EMEKLİOĞLU B,Çakır N,CAKIR I,Kendirci M,KOC A "Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children." Erciyes Medical Journal, 43, ss.427 - 432, 2021. 10.14744/etd.2021.35920
ISNAD EMEKLİOĞLU, Burcu vd. "Assessment of Fungal Genital Infection Frequency,Antifungal Sensitivity, and the Impact of HemoglobinA1c Levels on These Infections in Diabetic Children". Erciyes Medical Journal 43/5 (2021), 427-432. https://doi.org/10.14744/etd.2021.35920