Yıl: 2021 Cilt: 9 Sayı: 2 Sayfa Aralığı: 76 - 82 Metin Dili: İngilizce DOI: 10.32596/ejcm.galenos.2021-01-03 İndeks Tarihi: 22-01-2022

High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study

Öz:
Objectives: The triglyceride glucose index (TyG index) calculated by fasting plasma glucose and triglycerides is associated with hypertension, diabetes and metabolic syndrome (MetS). However, the studies investigating the role of the TyG index in coronary artery disease (CAD) are limited and conflicting. In this study, we aimed to determine the role of the TyG index in the presence and severity of CAD in patients with acute coronary syndrome (ACS). Materials and Methods: Eighty-three ACS patients (mean age: 64.64±12.79 years; male gender, 65%) and 50 control subjects with normal coronary arteries (58.50±12.28 years, male, 56%) were analyzed, retrospectively. The severity of CAD was evaluated by Gensini and SYNTAX I scores and p <0.05 was considered statistically significant. Results: The TyG index did not differ significantly between ACS patients and controls (8.97±0.72 vs. 9.06±0.72, p=0.533). There was no correlation between the TyG index with SYNTAX and Gensini scores. In addition, TyG index was similar in subgroup analysis of ACS patients (p>0.05). When the subjects were divided according to the TyG index, those with high TyG index had a higher incidence of hypertension, diabetes, and lipid parameters deterioration (p<0.05). Conclusion: TyG index does not indicate the presence and severity of CAD but may be closely related to dysmetabolic conditions that predispose to CAD.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Smith SC Jr, Jackson R, Pearson TA, et al. Principles for national and regional guidelines on cardiovascular disease prevention: a scientific statement from the World Heart and Stroke Forum. Circulation 2004;109:3112-21.
  • 2. Lee EY, Yang HK, Lee J, et al. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis 2016;15:155.
  • 3. Kim JH, Lee DY, Park SE, et al. Triglyceride glucose index predicts coronary artery calcification better than other indices of insulin resistance in Korean adults: the Kangbuk Samsung Health Study. Precision and Future Medicine 2017;1:43-51.
  • 4. Wang L, Cong HL, Zhang JX, et al. Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome. Cardiovasc Diabetol 2020;19:80.
  • 5. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord 2008;6:299-304.
  • 6. Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 2016;37:267-315.
  • 7. Chalmers J, MacMahon S, Mancia G, et al. 1999 World Health Organization- International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines sub-committee of the World Health Organization. Clinical and Experimental Hypertansion. 1999;21:1009-60.
  • 8. American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care 2019;42(Suppl 1):13-28.9. SYNTAX working group. SYNTAX score calculator. Available at http:// www.syntaxscore.com. Accessed May 20, 2012.
  • 10. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51:606.
  • 11. Linton MF, Fazio S. Macrophages, inflammation, and atherosclerosis. Int J Obes Relat Metab Disord 2003;27:35-40.
  • 12. Yamazoe M, Hisamatsu T, Miura K, et al. Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components: Shiga Epidemiological Study of Subclinical Atherosclerosis. Arterioscler Thromb Vasc Biol 2016;36:1703-8.
  • 13. Lee KK, Fortmann SP, Fair JM, et al. Insulin resistance independently predicts the progression of coronary artery calcification. Am Heart J 2009;157:939-45.
  • 14. Sánchez-Íñigo L, Navarro-González D, Fernández-Montero A, Pastrana- Delgado J, Martínez JA. The TyG index may predict the development of cardiovascular events. Eur J Clin Invest 2016;46:189-97.
  • 15. Kim MK, Ahn CW, Kang S, Nam JS, Kim KR, Park JS. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc Diabetol 2017;16:108.
  • 16. Cho YR, Ann SH, Won KB, et al. Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes. Sci Rep 2019;9:6129.
  • 17. Vega GL, Barlow CE, Grundy SM, Leonard D, DeFina LF. Triglycerideto- high-density-lipoprotein-cholesterol ratio is an index of heart disease mortality and of incidence of type 2 diabetes mellitus in men. J Investig Med 2014;62:345-9.
  • 18. Da Silva A, Caldas APS, Hermsdorff HHM, et al. Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care. Cardiovasc Diabetol 2019;18:89.
  • 19. Mao Q, Zhou D, Li Y, Wang Y, Xu SC, Zhao XH. The Triglyceride-Glucose Index Predicts Coronary Artery Disease Severity and Cardiovascular Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome. Dis Markers 2019;2019:6891537.
  • 20. Sulistyono T, Nughara T, Wasyanto T. Glucose trigliserides index as a predictor of severity of coronary artery assesesed with syntax score I in acıuye coronary syndrome patients. Acta Cardiologia Indonesiana 2020;6:127-34.
  • 21. Steg PG, Goldberg RJ, Gore JM, et al. Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE). Am J Cardiol 2002;90:358-63.
APA Cetin Sanlialp S, NAR G, ŞEN G, GÜNVER M, Şanlıalp M (2021). High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. , 76 - 82. 10.32596/ejcm.galenos.2021-01-03
Chicago Cetin Sanlialp Sara,NAR Gökay,ŞEN Gürsel,GÜNVER Mehmet Güven,Şanlıalp Musa High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. (2021): 76 - 82. 10.32596/ejcm.galenos.2021-01-03
MLA Cetin Sanlialp Sara,NAR Gökay,ŞEN Gürsel,GÜNVER Mehmet Güven,Şanlıalp Musa High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. , 2021, ss.76 - 82. 10.32596/ejcm.galenos.2021-01-03
AMA Cetin Sanlialp S,NAR G,ŞEN G,GÜNVER M,Şanlıalp M High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. . 2021; 76 - 82. 10.32596/ejcm.galenos.2021-01-03
Vancouver Cetin Sanlialp S,NAR G,ŞEN G,GÜNVER M,Şanlıalp M High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. . 2021; 76 - 82. 10.32596/ejcm.galenos.2021-01-03
IEEE Cetin Sanlialp S,NAR G,ŞEN G,GÜNVER M,Şanlıalp M "High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study." , ss.76 - 82, 2021. 10.32596/ejcm.galenos.2021-01-03
ISNAD Cetin Sanlialp, Sara vd. "High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study". (2021), 76-82. https://doi.org/10.32596/ejcm.galenos.2021-01-03
APA Cetin Sanlialp S, NAR G, ŞEN G, GÜNVER M, Şanlıalp M (2021). High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. E Journal of Cardiovascular Medicine, 9(2), 76 - 82. 10.32596/ejcm.galenos.2021-01-03
Chicago Cetin Sanlialp Sara,NAR Gökay,ŞEN Gürsel,GÜNVER Mehmet Güven,Şanlıalp Musa High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. E Journal of Cardiovascular Medicine 9, no.2 (2021): 76 - 82. 10.32596/ejcm.galenos.2021-01-03
MLA Cetin Sanlialp Sara,NAR Gökay,ŞEN Gürsel,GÜNVER Mehmet Güven,Şanlıalp Musa High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. E Journal of Cardiovascular Medicine, vol.9, no.2, 2021, ss.76 - 82. 10.32596/ejcm.galenos.2021-01-03
AMA Cetin Sanlialp S,NAR G,ŞEN G,GÜNVER M,Şanlıalp M High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. E Journal of Cardiovascular Medicine. 2021; 9(2): 76 - 82. 10.32596/ejcm.galenos.2021-01-03
Vancouver Cetin Sanlialp S,NAR G,ŞEN G,GÜNVER M,Şanlıalp M High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study. E Journal of Cardiovascular Medicine. 2021; 9(2): 76 - 82. 10.32596/ejcm.galenos.2021-01-03
IEEE Cetin Sanlialp S,NAR G,ŞEN G,GÜNVER M,Şanlıalp M "High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study." E Journal of Cardiovascular Medicine, 9, ss.76 - 82, 2021. 10.32596/ejcm.galenos.2021-01-03
ISNAD Cetin Sanlialp, Sara vd. "High Triglyceride Glucose Index Does Not Show the Presence and Severity of Coronary Artery Disease: A Single- Center Study". E Journal of Cardiovascular Medicine 9/2 (2021), 76-82. https://doi.org/10.32596/ejcm.galenos.2021-01-03