Role of dyslipidemia in early vascular aging syndrome

BAYDAR, ONUR; Kilic, Alparslan; Can, Mehmet; ELÇİK, Deniz; Apaydın, Ziya

doi:10.3906/sag-2008-165

Role of dyslipidemia in early vascular aging syndrome

Alparslan KILIÇ, (Koç Üniversitesi Hastanesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Onur BAYDAR, (Koç Üniversitesi Hastanesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Deniz ELÇİK, (Erciyes Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kayseri, Türkiye)

Ziya APAYDIN, (Haseki Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, İstanbul, Türkiye)

Mehmet Mustafa CAN (Haseki Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, İstanbul, Türkiye)

Turkish Journal of Medical Sciences

0 2

Yıl: 2021 Cilt: 51 Sayı: 2 Sayfa Aralığı: 727 - 734 Metin Dili: İngilizce DOI: 10.3906/sag-2008-165 İndeks Tarihi: 24-01-2022

Role of dyslipidemia in early vascular aging syndrome

Öz:

Background/aim: Arterial stiffness, known as a predictor of early vascular aging, was defined as the main determinant of cardiovascular mortality and morbidity. However, the relationship between lipid profile and increased arterial stiffness is not clear. The aim of this study is to investigate the relationship between lipid profiles and increased arterial stiffness in patients with early vascular aging syndrome. Materials and methods: A total of 1582 participants —504 (31.8%) of were male and the mean age was 52.8 ±14.2 years— were included in the study . Patients who applied to the hospital for various reasons and who had undergone 24-h blood pressure Holter monitoring were included in this study. Patients were divided into four groups according to pulse wave velocity (PWV) quartiles (Q1 (<6.3), Q2 (6.3–7.4), Q3 (7.5–8.8), Q4 (>8.8)). Results: We found that in the highest PWV group, patients had higher systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, blood urea nitrogen (BUN), creatinine, urinary albumin excretion (UAE), uric acid(UA), total cholesterol (TC), low-density lipoprotein ( LDL-C), triglycerid (TG), and non- high-density lipoprotein (HDL-C ) levels. Additionally, diabetes mellitus (dm), age, non-HDL-C, and TG/ HDL-C levels were detected as independent risk factors of increased PWV in ordinal logistic regression analysis. Conclusion: Our study demonstrates that lipid parameters are strongly correlated with increased PWVvalue and early vascular aging. In daily clinical practice, TGHDL-C ratio, known as atherogenic index, might be used routinely for predicted of early vascular aging and subclinical atherosclerosis.Key words: Arterial stiffness, vascular aging, lipid profile

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Zhao W, Gong W, Wu N, Li Y, Ye K et al. Association of lipid profiles and the ratios with arterial stiffness in middle-aged and elderly Chinese. Lipids in Health and Disease 2014 20;13 (1): 37. doi: 10.1186/1476-511X-13-37
2. Kilic A. Reference pulse wave velocity values in a normotensive healthy Turkish population. Turk Kardiyoloji Derneği Arşivi 2019; 47 (5): 373-378. doi: 10.5543/tkda.2019.92428 3. Kilic A, Baydar O. The relationship between diurnal blood pressure abnormalities and target organ damage in normotensive subjects. Which is more important? Increased blood pressure levels or circadian blood pressure abnormalities. Clinical and Experimental Hypertension 2020; 42 (3): 244-249 doi: 10.1080/10641963.2019.1619757
4. Laurent S, Marais L, Boutouyrie P. The noninvasive assessment of vascular aging. Canadian Journal of Cardiology 2016; 32 (5): 669-79. doi: 10.1016/j.cjca.2016.01.039
5. Yadav D, Kim SJ, Kim JR, Cho KH. Correlation among lipid parameters, pulse wave velocity and central blood pressure in young Korean population. Clinical and Experimental Hypertension 2019; 41 (1): 20-27. doi: 10.1080/10641963.2018.1441856
6. Zhan B, Huang X, Wang J, Qin X, Zhang J et al. Association between lipid profiles and arterial stiffness in Chinese patients with hypertension: Insights from the CSPPT. Angiology 2019; 70 (6): 515-522. doi: 10.1177/0003319718823341
7. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B et al. Aortic stifness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37 (5): 1236-1241. doi: 10.1161/01. hyp.37.5.1236
8. Hwang HS, Ko KP, Kim MG, Kim S, Moon J et al. The role of abnormal metabolic conditions on arterial stifness in healthy subjects with no drug treatment. Clinical Hypertension 2016; 22: 13. doi: 10.1186/s40885-016-0049-6
9. Rodrigues S, Cepeda FX, Toschi-Dias E, Dutra-Marques Akothirene CB et al. The role of increased glucose on neurovascular dysfunction in patients with the metabolic syndrome. Journal of Clinical Hypertension 2017; 19 (9): 840- 847. doi: 10.1111/jch.13060
10. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stifness. Arteriosclerosis, Thrombosis and Vascular Biology 2005; 25: 932-943. doi:10.1161/01.ATV.0000160548.78317.29
11. Chan W, Tong P, Chow C, So W, Ng M et al. Triglyceride predicts cardiovascular mortality and its relationship with glycaemia and obesity in Chinese type 2 diabetic patients. Diabetes/ Metabolism Research and Reviews 2005; 21 (2):183-188. doi: 10.1002/dmrr.497
12. Milionis HJ, Elisaf MS, Mikhailidis DP. Lipid abnormalities and cardiovascular risk in the elderly. Current Medical Research and Opinion 2008; 24 (3): 653-657. doi: 10.1185/030079908X273363
13. Jeppesen J, Hein HO, Suadicani P, Gyntelberg F. Low triglycerides–high high-density lipoprotein cholesterol and risk of ischemic heart disease. Archives of Internal Medicine 2001;161 (3): 361-366. doi: 10.1001/archinte.161.3.361
14. Hokanson JE. Hypertriglyceridemia as a cardiovascular risk factor. The American Journal of Cardiology 1998; 81 (4): 7-12. doi: 10.1016/s0002-9149(98)00031-9
15. Kilic A, Baydar O, Elcioglu BC, Camkiran V, Apaydin Z et al. Understanding vascular age: are clinical scoring systems useful for early vascular aging syndrome prediction? High Blood Pressure and Cardiovascular Prevention 2020; 42 (3): 244-249. doi: 10.1007/s40292-020-00417-7
16. Hirata A, Okamura T, Sugiyama D, Kuwabara K, Kadota A et al. NIPPON DATA 90 Research Group: The relationship between very high levels of serum high-density lipoprotein cholesterol and cause-specific mortality in a 20-year follow-up study of Japanese general population. Journal of Atherosclerosis and Thrombosis 2016; 23: 800-809. doi: 10.5551/jat.33449
17. Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC et al. Association of LDL cholesterol, non–HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. Jama 2012; 307 (12): 1302-1309. doi: 10.1001/jama.2012.366
18. Poledne R, Lesna IK, Kralova A, Fronek J, Cejkova S. The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue. Journal of Lipid Research 2016; 57 (10): 1899-1905. doi: 10.1194/jlr.P068015
19. Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men: prospective results from the Qué bec Cardiovascular Study. Circulation 1997; 95 (1): 69-75. doi: 10.1161/01.cir.95.1.69
20. Pitha J, Kovar J, Blahová T. Fasting and nonfasting triglycerides in cardiovascular and other diseases. Physiological Research 2015; 64: 323. doi: 10.33549/physiolres.933196
21. Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. European Journal of Internal Medicine 2014; 25 (8): 689-694. doi: 10.1016/j. ejim.2014.08.008
22. Sundaram M, Curtis KR, Alipour MA, LeBlond ND, Margison KD et al. The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation. Journal of Lipid Research 2017; 58 (11): 2188- 2196. doi: 10.1194/jlr.M077313
23. Oram JF. HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol. Arteriosclerosis, Thrombosis, and Vascular Biology 2003; 23 (5): 720-727. doi: 10.1161/01.ATV.0000054662.44688.9A
24. Wen J, Zhong Y, Kuang C, Liao J, Chen Z et al. Lipoprotein ratios are better than conventional lipid parameters in predicting arterial stiffness in young men. Journal of Clinical Hypertension 2017; 19 (8): 771-776. doi: 10.1111/jch.13038
25. Assesment R. Major lipids, apolipoproteins, and risk of vascular disease. Jama 2009; 302 (18): 1993-2000. doi: 10.1001/ jama.2009.1619
26. Harrison SC, Holmes MV, Humphries SE. Mendelian randomisation, lipids, and cardiovascular disease. The Lancet 2012; 380 (9841): 543-545. doi: 10.1016/S0140-6736(12)60481-4
27. Kimm H, Lee SW, Lee HS, Shim KW, Cho CY et al. Associations between lipid measures and metabolic syndrome, insulin resistance and adiponectin. Circulation Journal 2010; 74 (5): 931-937. doi: 10.1253/circj.cj-09-0571
28. Yang T. Insulin sensitivity and beta-cell function are associated with arterial stiffness in individuals without hypertension. Experimental Diabetes Research 2013; 2013: 151675. doi: 10.1155/2013/151675
29. Laws A, Reaven G. Evidence for an independent relationship between insulin resistance and fasting plasma HDL‐cholesterol, triglyceride and insulin concentrations. Journal of Internal Medicine 1992; 231 (1): 25-30. doi: 10.1111/j.1365-2796.1992. tb00494.x
30. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C et al. Use of metabolic markers to identify overweight individuals who are insulin resistant. Annals of Internal Medicine 2003; 139 (10): 802-809. doi: 10.7326/0003-4819-139-10-200311180- 00007

APA	Kilic A, BAYDAR O, ELÇİK D, Apaydın Z, Can M (2021). Role of dyslipidemia in early vascular aging syndrome. , 727 - 734. 10.3906/sag-2008-165
Chicago	Kilic Alparslan,BAYDAR ONUR,ELÇİK Deniz,Apaydın Ziya,Can Mehmet Role of dyslipidemia in early vascular aging syndrome. (2021): 727 - 734. 10.3906/sag-2008-165
MLA	Kilic Alparslan,BAYDAR ONUR,ELÇİK Deniz,Apaydın Ziya,Can Mehmet Role of dyslipidemia in early vascular aging syndrome. , 2021, ss.727 - 734. 10.3906/sag-2008-165
AMA	Kilic A,BAYDAR O,ELÇİK D,Apaydın Z,Can M Role of dyslipidemia in early vascular aging syndrome. . 2021; 727 - 734. 10.3906/sag-2008-165
Vancouver	Kilic A,BAYDAR O,ELÇİK D,Apaydın Z,Can M Role of dyslipidemia in early vascular aging syndrome. . 2021; 727 - 734. 10.3906/sag-2008-165
IEEE	Kilic A,BAYDAR O,ELÇİK D,Apaydın Z,Can M "Role of dyslipidemia in early vascular aging syndrome." , ss.727 - 734, 2021. 10.3906/sag-2008-165
ISNAD	Kilic, Alparslan vd. "Role of dyslipidemia in early vascular aging syndrome". (2021), 727-734. https://doi.org/10.3906/sag-2008-165

APA	Kilic A, BAYDAR O, ELÇİK D, Apaydın Z, Can M (2021). Role of dyslipidemia in early vascular aging syndrome. Turkish Journal of Medical Sciences, 51(2), 727 - 734. 10.3906/sag-2008-165
Chicago	Kilic Alparslan,BAYDAR ONUR,ELÇİK Deniz,Apaydın Ziya,Can Mehmet Role of dyslipidemia in early vascular aging syndrome. Turkish Journal of Medical Sciences 51, no.2 (2021): 727 - 734. 10.3906/sag-2008-165
MLA	Kilic Alparslan,BAYDAR ONUR,ELÇİK Deniz,Apaydın Ziya,Can Mehmet Role of dyslipidemia in early vascular aging syndrome. Turkish Journal of Medical Sciences, vol.51, no.2, 2021, ss.727 - 734. 10.3906/sag-2008-165
AMA	Kilic A,BAYDAR O,ELÇİK D,Apaydın Z,Can M Role of dyslipidemia in early vascular aging syndrome. Turkish Journal of Medical Sciences. 2021; 51(2): 727 - 734. 10.3906/sag-2008-165
Vancouver	Kilic A,BAYDAR O,ELÇİK D,Apaydın Z,Can M Role of dyslipidemia in early vascular aging syndrome. Turkish Journal of Medical Sciences. 2021; 51(2): 727 - 734. 10.3906/sag-2008-165
IEEE	Kilic A,BAYDAR O,ELÇİK D,Apaydın Z,Can M "Role of dyslipidemia in early vascular aging syndrome." Turkish Journal of Medical Sciences, 51, ss.727 - 734, 2021. 10.3906/sag-2008-165
ISNAD	Kilic, Alparslan vd. "Role of dyslipidemia in early vascular aging syndrome". Turkish Journal of Medical Sciences 51/2 (2021), 727-734. https://doi.org/10.3906/sag-2008-165