Objective: The effect of intravenous ibuprofen preemptively administered in pain managementafter double jaw surgery are limited.The purpose of the present study was to investigate the effectsof preemptive intravenous ibuprofen on postoperative analgesia and opioid consumption in patientswho undergo double jaw surgery (DJS). Materials and Methods: After ethical committee approval, 48 patients, American Society ofAnesthesiologist (ASA) I-II, scheduled for DJS were randomly assigned into two groups. Theibuprofen group (n=24) received 800 mg IV ibuprofen in 100 mL saline, while the control group(n=24) received 100 mL saline, thirty minutes before the surgery. All patients were administered1.000 mg iv paracetamol 30 minutes before the surgery ended and was repeated every 6 hours.Postoperative analgesia was performed with patient controlled analgesia (PCA). The pain of thegroups was evaluated with Visual Analog Scale (VAS), and the total opioid consumption wasrecorded at the end of 24 hours.Results: VAS scores of the patients were compared with the Control Group, the VAS scores weresignificantly lower in the ibuprofen group at 1st, 2nd, 4th, 8th, 12th and 24th hours (P<0.05). The totalopioid consumption was found to be statistically higher in the control group than in the ibuprofengroup (326.04 μcg and 163.95 μcg, P<0.05). The need for additional analgesics was more in thecontrol group than in the Ibuprofen Group (14/24, 6/24). Nausea and vomiting were statisticallymore in the control group (P<0.05). No significant differences were detected between the groups interms of hemorrhage (P>0.05). Conclusion: Preemptive IV Ibuprofen may be one of the alternative analgesic drugs which mightbe used in DJS.