The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma

ŞAHİN, Taha Koray; Ardic, Fadime Sinem; erman, mustafa; Yüce, Deniz; Guner, Gurkan; yalcin, suayib; Guven, Deniz Can; Aktepe, Oktay Halit

doi:10.3906/sag-2009-75

The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma

OKTAY HALİT AKTEPE, (Hacettepe Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, Ankara, Türkiye)

Gürkan GÜNER, (Hacettepe Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, Ankara, Türkiye)

Deniz Can GÜVEN, (Hacettepe Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, Ankara, Türkiye)

Taha Koray ŞAHİN, (Hacettepe Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Fadime Sinem ARDIÇ, (Hacettepe Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Deniz YÜCE, (Hacettepe Üniversitesi, Tıp Fakültesi, Koruyucu Onkoloji Anabilim Dalı, Ankara, Türkiye)

Şuayip YALÇIN, (Hacettepe Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, Ankara, Türkiye)

Mustafa ERMAN (Hacettepe Üniversitesi, Tıp Fakültesi, Koruyucu Onkoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

3 1

Yıl: 2021 Cilt: 51 Sayı: 2 Sayfa Aralığı: 757 - 765 Metin Dili: İngilizce DOI: 10.3906/sag-2009-75 İndeks Tarihi: 24-01-2022

The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma

Öz:

Background/aim: The prognostic values of systemic inflammatory markers, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) on overall survival (OS) of metastatic renal cell carcinoma patients (mRCC) treated with tyrosine kinase inhibitors (TKI) remain unclear. Thus, the present study aimed to investigate the prognostic impact of these markers on OS of mRCC patients. Materials and methods: A total of 150 patients receiving TKIs were retrospectively analyzed. Progression-free survival and OS times were analyzed with the Kaplan–Meier method, and the log‐rank test was used for comparison. Univariable and multivariable Cox regression models evaluated the impact of NLR and PLR on OS of the patients. The receiver operating characteristic curve analysis determined that the optimal cut-off values of NL, and PLR in predicting OS were 2 and 204, respectively. Results: Patient with PLR > 204 had significantly lower median OS time than those with PLR ≤ 204 (14.6 months vs. 31.6 months, P < 0.001). While the univariate analyses showed that both NLR and PLR associated with OS (NLR: P = 0.002; PLR: P < 0.001), PLR, not NLR, was an independent determinant for OS in the multivariate analyses (Hazard Ratio: 2.535, 95% CI: 1.564-4.108, P < 0.001). Additionally, the presence of brain metastases and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) prognostic scoring system were identified as independent prognostic factors for OS (brain metastases: P = 0.040; IMDC: P < 0.001). Conclusion: The PLR is a readily and inexpensively obtained marker, which may predict OS in patients with mRCC treated with TKIs.Key words: NLR, PLR, metastatic renal cell carcinoma, prognosis, tyrosine kinase inhibitors

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Aktepe O, Guner G, Guven D, ŞAHİN T, Ardic F, Yüce D, yalcin s, erman m (2021). The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. , 757 - 765. 10.3906/sag-2009-75
Chicago	Aktepe Oktay Halit,Guner Gurkan,Guven Deniz Can,ŞAHİN Taha Koray,Ardic Fadime Sinem,Yüce Deniz,yalcin suayib,erman mustafa The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. (2021): 757 - 765. 10.3906/sag-2009-75
MLA	Aktepe Oktay Halit,Guner Gurkan,Guven Deniz Can,ŞAHİN Taha Koray,Ardic Fadime Sinem,Yüce Deniz,yalcin suayib,erman mustafa The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. , 2021, ss.757 - 765. 10.3906/sag-2009-75
AMA	Aktepe O,Guner G,Guven D,ŞAHİN T,Ardic F,Yüce D,yalcin s,erman m The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. . 2021; 757 - 765. 10.3906/sag-2009-75
Vancouver	Aktepe O,Guner G,Guven D,ŞAHİN T,Ardic F,Yüce D,yalcin s,erman m The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. . 2021; 757 - 765. 10.3906/sag-2009-75
IEEE	Aktepe O,Guner G,Guven D,ŞAHİN T,Ardic F,Yüce D,yalcin s,erman m "The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma." , ss.757 - 765, 2021. 10.3906/sag-2009-75
ISNAD	Aktepe, Oktay Halit vd. "The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma". (2021), 757-765. https://doi.org/10.3906/sag-2009-75

APA	Aktepe O, Guner G, Guven D, ŞAHİN T, Ardic F, Yüce D, yalcin s, erman m (2021). The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. Turkish Journal of Medical Sciences, 51(2), 757 - 765. 10.3906/sag-2009-75
Chicago	Aktepe Oktay Halit,Guner Gurkan,Guven Deniz Can,ŞAHİN Taha Koray,Ardic Fadime Sinem,Yüce Deniz,yalcin suayib,erman mustafa The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. Turkish Journal of Medical Sciences 51, no.2 (2021): 757 - 765. 10.3906/sag-2009-75
MLA	Aktepe Oktay Halit,Guner Gurkan,Guven Deniz Can,ŞAHİN Taha Koray,Ardic Fadime Sinem,Yüce Deniz,yalcin suayib,erman mustafa The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. Turkish Journal of Medical Sciences, vol.51, no.2, 2021, ss.757 - 765. 10.3906/sag-2009-75
AMA	Aktepe O,Guner G,Guven D,ŞAHİN T,Ardic F,Yüce D,yalcin s,erman m The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. Turkish Journal of Medical Sciences. 2021; 51(2): 757 - 765. 10.3906/sag-2009-75
Vancouver	Aktepe O,Guner G,Guven D,ŞAHİN T,Ardic F,Yüce D,yalcin s,erman m The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma. Turkish Journal of Medical Sciences. 2021; 51(2): 757 - 765. 10.3906/sag-2009-75
IEEE	Aktepe O,Guner G,Guven D,ŞAHİN T,Ardic F,Yüce D,yalcin s,erman m "The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma." Turkish Journal of Medical Sciences, 51, ss.757 - 765, 2021. 10.3906/sag-2009-75
ISNAD	Aktepe, Oktay Halit vd. "The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma". Turkish Journal of Medical Sciences 51/2 (2021), 757-765. https://doi.org/10.3906/sag-2009-75