Purpose: To compare the corneal densitometry (CD) measurements in patients with pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). Materials and Methods: This prospective comparative study included 22 eyes with PG, 19 eyes with PDS and 21 control individuals. After complete ophthalmological examination, all the eyes had central corneal thickness (CCT) and CD measurements by densitometry software of Pentacam HR-Scheimpflug corneal topography over a 12-mm diameter of the cornea. Chi-Square, Kolmogorov-Smirnov, analysis of variance, and Tukey’s post-hoc tests were used for statistical analysis. Results: All the eyes with PG were under prostaglandin monotherapy. The mean CCT was significantly higher in PG cases than the other groups (p=0.01). The mean CD of anterior layer at the 0-2 mm was significantly higher in PG than PDS cases and normal subjects (p=0.007). The mean CD of total layer at the 0-2 mm was significantly higher in PG cases than control subjects (p=0.03). The mean CD of anterior layer at the 2-6 mm was significantly higher in PG than PDS cases (p=0.04). There were no significant differences of CD in other zones and layers between the groups. Conclusion: The presence of Krukenberg spindle, higher age in PG and the probable effects of glaucoma might cause corneal backscatter of light and increased CD particularly in anterior layers in central zones of cornea.