TY  - JOUR
TI  - Effects of topical mitomycin-C on the tracheal epithelia of rabbits following tracheostomy
AB  - Background/aim: We aimed to investigate the topical application of mitomycin-C (MMC) after the conventional tracheostomy in a rabbit model. Materials and methods: Twenty-four male New Zealand White rabbits were randomly divided among 3 equal groups (n: 8). Tracheostomies were performed on 16 subjects. Group 1 which served as a control for all tracheal measurements. After tracheostomy, we applied sterile saline (group 2) or MMC at 0.8 mg/mL (group 3) around the tracheotomy site for 5 min. At the 3rd week after surgery, all tracheas were subjected to morphometric and histopathological examinations, including tracheal lumen diameter (LD), number of capillary vessels (CV), subepithelial tissue thickness (SETT), fibroblasts, and inflammatory cells (IC). Results: There was a statistically significant difference between the two tracheostomy groups themselves and the control group for LD (p= 0.035), CV (p = 0.006), SETT, fibroblasts, and IC (p < 0.001). Histopathological analysis showed the decreased LD, CV, SETT, IC, and fibroblasts compared to MMC with tracheostomy groups. MMC was more effective than saline for LD, CV, SETT, IC, and fibroblasts. Conclusion: Wound healing modulation may prevent scar formation. Fibrosis decreased following tracheostomy in the group treated with MMC. Fibroblasts appear to be key cells mediating these effects.Key words: Tracheostomy, tracheal epithelia, rabbits, mitomycin-C (MMC)
AU  - ARIBAS, Olgun Kadir
AU  - Esme, Hidir
AU  - Arslan Kasdoagan, Zumrut Ela
AU  - CALIK, Mustafa
AU  - Calik, Saniye Goknil
AU  - AVUNDUK, MUSTAFA CIHAT
DO  - 10.3906/sag-1802-187
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 2
SN  - 1300-0144
SP  - 857
EP  - 863
DB  - TRDizin
UR  - http://search/yayin/detay/484968
ER  -