act of low molecular weight heparin administration on the clinical course of the COVID-19 disease

Yıl: 2021 Cilt: 51 Sayı: 1 Sayfa Aralığı: 28 - 38 Metin Dili: İngilizce DOI: 10.3906/sag-2006-184

act of low molecular weight heparin administration on the clinical course of the COVID-19 disease

Öz:
Background: Lymphopenia is the most important criterion of mortality and discharging feature for patients infected with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical impact of a low molecular weight heparin (LMWH) treatment on the clinical course of COVID-19. Materials and methods: Patients’ clinical symptoms, radiologic outcomes, hematologic, biochemical, D-dimer, and C-reactive protein (CRP) results were obtained from their medical records. Participants were separated into 2 groups: one was treated with LMWH and the other was not. Improvement in the patients was compared before and after treatment. Results: Ninety-six patients who were diagnosed with COVID-19 between April and May 2020 were retrospectively analyzed. The multivariable analysis showed that the count of lymphocytes, D-dimer, and CRP levels were significantly improved in the LMWH group, as compared to the control group (OR, (95% CI) 0.628 (0.248–0.965), P < 0.001); OR, (95% CI) 0.356 (0.089–0.674), P < 0.001, respectively). The area under the receiver operating characteristic (ROC) curve analysis was AUC: 0.679 ± 0.055, 0.615 ± 0.058, and 0.633 ± 0.057, respectively; the β-value was found to be –1.032, –0.026, and –0.465, respectively. Conclusion: The LMWH treatment group demonstrated better laboratory findings, including recovery in the lymphocyte count, CRP, and D-dimer results. Key words: Coronavirus disease-19, heparin, antiinflammatory, lymphocyte
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APA TÜLEK B, ARSLAN U, KANAT F, YORMAZ B, ERGÜN D, ERGÜN R (2021). act of low molecular weight heparin administration on the clinical course of the COVID-19 disease. Turkish Journal of Medical Sciences, 51(1), 28 - 38. 10.3906/sag-2006-184
Chicago TÜLEK Baykal,ARSLAN Uğur,KANAT Fikret,YORMAZ Burcu,ERGÜN Dilek,ERGÜN Recai act of low molecular weight heparin administration on the clinical course of the COVID-19 disease. Turkish Journal of Medical Sciences 51, no.1 (2021): 28 - 38. 10.3906/sag-2006-184
MLA TÜLEK Baykal,ARSLAN Uğur,KANAT Fikret,YORMAZ Burcu,ERGÜN Dilek,ERGÜN Recai act of low molecular weight heparin administration on the clinical course of the COVID-19 disease. Turkish Journal of Medical Sciences, vol.51, no.1, 2021, ss.28 - 38. 10.3906/sag-2006-184
AMA TÜLEK B,ARSLAN U,KANAT F,YORMAZ B,ERGÜN D,ERGÜN R act of low molecular weight heparin administration on the clinical course of the COVID-19 disease. Turkish Journal of Medical Sciences. 2021; 51(1): 28 - 38. 10.3906/sag-2006-184
Vancouver TÜLEK B,ARSLAN U,KANAT F,YORMAZ B,ERGÜN D,ERGÜN R act of low molecular weight heparin administration on the clinical course of the COVID-19 disease. Turkish Journal of Medical Sciences. 2021; 51(1): 28 - 38. 10.3906/sag-2006-184
IEEE TÜLEK B,ARSLAN U,KANAT F,YORMAZ B,ERGÜN D,ERGÜN R "act of low molecular weight heparin administration on the clinical course of the COVID-19 disease." Turkish Journal of Medical Sciences, 51, ss.28 - 38, 2021. 10.3906/sag-2006-184