A Snapshot of Oral Microbiota in Patients with Colorectal Cancer
Yıl: 2021 Cilt: 5 Sayı: 2 Sayfa Aralığı: 166 - 171 Metin Dili: İngilizce DOI: 10.14744/ejmi.2021.34738 İndeks Tarihi: 25-01-2022
A Snapshot of Oral Microbiota in Patients with Colorectal Cancer
Öz: limited. Based on this, we aimed to investigate the composition of oral microbiota in CRC and to compare them withhealthy controls. Methods: Saliva samples from 32 patients who were diagnosed with CRC and from 32 healthy controls in the same agegroup were evaluated in this study. Bacterial populations were identified through the multiplication of partial 16S rDNAsequences and comparison with databases after next-generation sequencing (Illumina MiSeq). Results: In family-level examinations, the relative abundance of Pasteurellaceae was decreased and that of Neisseriaceae was increased in patient group (p=0.008 and p=0.036, respectively). The relative abundance of Bacillales showeda negative correlation with disease stage (r=-0.638, p<0.001), while the relative abundance of Proteobacteria showed apositive correlation with the stage of disease (r=0.450, p=0.01). Conclusion: In our study, there were significant differences between the relative abundances of Pasteurellaceae andNeisseriaceae in the saliva of CRC patients. Additionally, the correlation between disease stage and abundance of Bacillales and Proteobacteria members was a novel finding, which needs validation in larger series. These findings mighthave implications for screening and prognostication of CRC.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
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APA | GÜVEN D, ERGUNAY K, BRİNKMANN A, ALP A, KİTTANA F, AKYON Y, Yilmaz E, Karakoc D, YALÇIN S, NİTSCHE A, Hayran M, DİZDAR O (2021). A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. , 166 - 171. 10.14744/ejmi.2021.34738 |
Chicago | GÜVEN Deniz Can,ERGUNAY Koray,BRİNKMANN Annika,ALP Alpaslan,KİTTANA Fatma Nur,AKYON Yakut,Yilmaz Engin,Karakoc Derya,YALÇIN Suayip,NİTSCHE Andreas,Hayran Mutlu,DİZDAR Omer A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. (2021): 166 - 171. 10.14744/ejmi.2021.34738 |
MLA | GÜVEN Deniz Can,ERGUNAY Koray,BRİNKMANN Annika,ALP Alpaslan,KİTTANA Fatma Nur,AKYON Yakut,Yilmaz Engin,Karakoc Derya,YALÇIN Suayip,NİTSCHE Andreas,Hayran Mutlu,DİZDAR Omer A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. , 2021, ss.166 - 171. 10.14744/ejmi.2021.34738 |
AMA | GÜVEN D,ERGUNAY K,BRİNKMANN A,ALP A,KİTTANA F,AKYON Y,Yilmaz E,Karakoc D,YALÇIN S,NİTSCHE A,Hayran M,DİZDAR O A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. . 2021; 166 - 171. 10.14744/ejmi.2021.34738 |
Vancouver | GÜVEN D,ERGUNAY K,BRİNKMANN A,ALP A,KİTTANA F,AKYON Y,Yilmaz E,Karakoc D,YALÇIN S,NİTSCHE A,Hayran M,DİZDAR O A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. . 2021; 166 - 171. 10.14744/ejmi.2021.34738 |
IEEE | GÜVEN D,ERGUNAY K,BRİNKMANN A,ALP A,KİTTANA F,AKYON Y,Yilmaz E,Karakoc D,YALÇIN S,NİTSCHE A,Hayran M,DİZDAR O "A Snapshot of Oral Microbiota in Patients with Colorectal Cancer." , ss.166 - 171, 2021. 10.14744/ejmi.2021.34738 |
ISNAD | GÜVEN, Deniz Can vd. "A Snapshot of Oral Microbiota in Patients with Colorectal Cancer". (2021), 166-171. https://doi.org/10.14744/ejmi.2021.34738 |
APA | GÜVEN D, ERGUNAY K, BRİNKMANN A, ALP A, KİTTANA F, AKYON Y, Yilmaz E, Karakoc D, YALÇIN S, NİTSCHE A, Hayran M, DİZDAR O (2021). A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. Eurasian Journal of Medical Investigation, 5(2), 166 - 171. 10.14744/ejmi.2021.34738 |
Chicago | GÜVEN Deniz Can,ERGUNAY Koray,BRİNKMANN Annika,ALP Alpaslan,KİTTANA Fatma Nur,AKYON Yakut,Yilmaz Engin,Karakoc Derya,YALÇIN Suayip,NİTSCHE Andreas,Hayran Mutlu,DİZDAR Omer A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. Eurasian Journal of Medical Investigation 5, no.2 (2021): 166 - 171. 10.14744/ejmi.2021.34738 |
MLA | GÜVEN Deniz Can,ERGUNAY Koray,BRİNKMANN Annika,ALP Alpaslan,KİTTANA Fatma Nur,AKYON Yakut,Yilmaz Engin,Karakoc Derya,YALÇIN Suayip,NİTSCHE Andreas,Hayran Mutlu,DİZDAR Omer A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. Eurasian Journal of Medical Investigation, vol.5, no.2, 2021, ss.166 - 171. 10.14744/ejmi.2021.34738 |
AMA | GÜVEN D,ERGUNAY K,BRİNKMANN A,ALP A,KİTTANA F,AKYON Y,Yilmaz E,Karakoc D,YALÇIN S,NİTSCHE A,Hayran M,DİZDAR O A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. Eurasian Journal of Medical Investigation. 2021; 5(2): 166 - 171. 10.14744/ejmi.2021.34738 |
Vancouver | GÜVEN D,ERGUNAY K,BRİNKMANN A,ALP A,KİTTANA F,AKYON Y,Yilmaz E,Karakoc D,YALÇIN S,NİTSCHE A,Hayran M,DİZDAR O A Snapshot of Oral Microbiota in Patients with Colorectal Cancer. Eurasian Journal of Medical Investigation. 2021; 5(2): 166 - 171. 10.14744/ejmi.2021.34738 |
IEEE | GÜVEN D,ERGUNAY K,BRİNKMANN A,ALP A,KİTTANA F,AKYON Y,Yilmaz E,Karakoc D,YALÇIN S,NİTSCHE A,Hayran M,DİZDAR O "A Snapshot of Oral Microbiota in Patients with Colorectal Cancer." Eurasian Journal of Medical Investigation, 5, ss.166 - 171, 2021. 10.14744/ejmi.2021.34738 |
ISNAD | GÜVEN, Deniz Can vd. "A Snapshot of Oral Microbiota in Patients with Colorectal Cancer". Eurasian Journal of Medical Investigation 5/2 (2021), 166-171. https://doi.org/10.14744/ejmi.2021.34738 |