TY  - JOUR
TI  - A Snapshot of Oral Microbiota in Patients with Colorectal Cancer
AB  - limited. Based on this, we aimed to investigate the composition of oral microbiota in CRC and to compare them withhealthy controls. Methods: Saliva samples from 32 patients who were diagnosed with CRC and from 32 healthy controls in the same agegroup were evaluated in this study. Bacterial populations were identified through the multiplication of partial 16S rDNAsequences and comparison with databases after next-generation sequencing (Illumina MiSeq). Results: In family-level examinations, the relative abundance of Pasteurellaceae was decreased and that of Neisseriaceae was increased in patient group (p=0.008 and p=0.036, respectively). The relative abundance of Bacillales showeda negative correlation with disease stage (r=-0.638, p<0.001), while the relative abundance of Proteobacteria showed apositive correlation with the stage of disease (r=0.450, p=0.01). Conclusion: In our study, there were significant differences between the relative abundances of Pasteurellaceae andNeisseriaceae in the saliva of CRC patients. Additionally, the correlation between disease stage and abundance of Bacillales and Proteobacteria members was a novel finding, which needs validation in larger series. These findings mighthave implications for screening and prognostication of CRC.
AU  - NİTSCHE, Andreas
AU  - YALÇIN, Suayip
AU  - DİZDAR, Omer
AU  - Karakoc, Derya
AU  - AKYON, Yakut
AU  - ALP, Alpaslan
AU  - Hayran, Mutlu
AU  - ERGUNAY, Koray
AU  - Yilmaz, Engin
AU  - BRİNKMANN, Annika
AU  - GÜVEN, Deniz Can
AU  - KİTTANA, Fatma Nur
DO  - 10.14744/ejmi.2021.34738
PY  - 2021
JO  - Eurasian Journal of Medical Investigation
VL  - 5
IS  - 2
SN  - 2602-3164
SP  - 166
EP  - 171
DB  - TRDizin
UR  - http://search/yayin/detay/485128
ER  -