Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience

Background/aim: To assess the real-life efficacy, retention rate, and safety data of tofacitinib in rheumatoid arthritis (RA) patients. Materials and methods: We analyzed all patients registered in the HURBİO database who received at least 1 dose of tofacitinib. Patients who received at least one dose were included in retention analysis; patients with at least 1 control visit were included in efficacy and safety analysis. Factors predicting good response at the last follow-up visit were analyzed by logistic regression analysis. Drug retention rates were calculated using the Kaplan–Meier method and predictors of drug retention were determined by Cox proportional hazard model. Adverse events, reasons for switching, and discontinuation were also determined. Results: Two hundred and forty-seven (210, 85.0% female) patients were included in the study. The median duration of tofacitinib treatment was 10.2 (20.2) [med, (IQR)] months. Two hundred and four (82.6%) patients were included in safety and efficacy analysis; 45.6% of patients were in low-disease activity (LDA) state (DAS28-CRP ≤ 3.2). Predictors of LDA were being biologic-naïve [aOR 2.53 (1.31–4.88); 95% CI] and RF negativity [aOR 2.14 (1.12–4.07); 95% CI]. At 1 year, the overall tofacitinib retention rate was 63.9% with no relevant predicting factor. Response and retention rates of tofacitinib were similar in patients with and without concomitant csDMARDs. Treatment failure was the most common cause of discontinuation. The most common infectious and laboratory adverse events were herpes zoster infection (3.9 per 100 patient-years) and elevation in ALT (x3UNL: 9.7 per 100 patient-years), respectively. Conclusion: Tofacitinib is effective as monotherapy or in combination with csDMARDs. It is a well-tolerated treatment option in Turkish RA patients.Key words: Rheumatoid arthritis, tofacitinib, real-life, predictor

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Bilgin E, CEYLAN F, Duran E, farisoğulları b, Bolek E, Yardimci G, Kılıç L, Akdogan A, Karadag O, Apras Bilgen S, KİRAZ S, Ertenli I, Kalyoncu U (2021). Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. , 297 - 308. 10.3906/sag-2007-123
Chicago	Bilgin Emre,CEYLAN Furkan,Duran Emine,farisoğulları bayram,Bolek Ertugrul Cagri,Yardimci Gozde Kubra,Kılıç Levent,Akdogan Ali,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,Kalyoncu Umut Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. (2021): 297 - 308. 10.3906/sag-2007-123
MLA	Bilgin Emre,CEYLAN Furkan,Duran Emine,farisoğulları bayram,Bolek Ertugrul Cagri,Yardimci Gozde Kubra,Kılıç Levent,Akdogan Ali,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,Kalyoncu Umut Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. , 2021, ss.297 - 308. 10.3906/sag-2007-123
AMA	Bilgin E,CEYLAN F,Duran E,farisoğulları b,Bolek E,Yardimci G,Kılıç L,Akdogan A,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,Kalyoncu U Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. . 2021; 297 - 308. 10.3906/sag-2007-123
Vancouver	Bilgin E,CEYLAN F,Duran E,farisoğulları b,Bolek E,Yardimci G,Kılıç L,Akdogan A,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,Kalyoncu U Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. . 2021; 297 - 308. 10.3906/sag-2007-123
IEEE	Bilgin E,CEYLAN F,Duran E,farisoğulları b,Bolek E,Yardimci G,Kılıç L,Akdogan A,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,Kalyoncu U "Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience." , ss.297 - 308, 2021. 10.3906/sag-2007-123
ISNAD	Bilgin, Emre vd. "Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience". (2021), 297-308. https://doi.org/10.3906/sag-2007-123

APA	Bilgin E, CEYLAN F, Duran E, farisoğulları b, Bolek E, Yardimci G, Kılıç L, Akdogan A, Karadag O, Apras Bilgen S, KİRAZ S, Ertenli I, Kalyoncu U (2021). Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. Turkish Journal of Medical Sciences, 51(1), 297 - 308. 10.3906/sag-2007-123
Chicago	Bilgin Emre,CEYLAN Furkan,Duran Emine,farisoğulları bayram,Bolek Ertugrul Cagri,Yardimci Gozde Kubra,Kılıç Levent,Akdogan Ali,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,Kalyoncu Umut Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. Turkish Journal of Medical Sciences 51, no.1 (2021): 297 - 308. 10.3906/sag-2007-123
MLA	Bilgin Emre,CEYLAN Furkan,Duran Emine,farisoğulları bayram,Bolek Ertugrul Cagri,Yardimci Gozde Kubra,Kılıç Levent,Akdogan Ali,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,Kalyoncu Umut Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. Turkish Journal of Medical Sciences, vol.51, no.1, 2021, ss.297 - 308. 10.3906/sag-2007-123
AMA	Bilgin E,CEYLAN F,Duran E,farisoğulları b,Bolek E,Yardimci G,Kılıç L,Akdogan A,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,Kalyoncu U Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. Turkish Journal of Medical Sciences. 2021; 51(1): 297 - 308. 10.3906/sag-2007-123
Vancouver	Bilgin E,CEYLAN F,Duran E,farisoğulları b,Bolek E,Yardimci G,Kılıç L,Akdogan A,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,Kalyoncu U Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience. Turkish Journal of Medical Sciences. 2021; 51(1): 297 - 308. 10.3906/sag-2007-123
IEEE	Bilgin E,CEYLAN F,Duran E,farisoğulları b,Bolek E,Yardimci G,Kılıç L,Akdogan A,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,Kalyoncu U "Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience." Turkish Journal of Medical Sciences, 51, ss.297 - 308, 2021. 10.3906/sag-2007-123
ISNAD	Bilgin, Emre vd. "Efficacy, retention, and safety of tofacitinib in real-life: Hur-bio monocentric experience". Turkish Journal of Medical Sciences 51/1 (2021), 297-308. https://doi.org/10.3906/sag-2007-123