Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma

Objectives: Prognostic nutritional index (PNI) is an inflammation-based score which was found to be predictive ofsurvival for different types of cancer. Aim of present study is to investigate the association between PNI and survivaloutcomes in patients with soft tissue sarcoma (STS) operated with curative intent. Methods: We retrospectively collected data of 86 patients with localized STS. Preoperative PNI was calculated with thefollowing formula:10×serum albumin (g/dL)+0.005×total lymphocyte count (per mm3 ). Patients were classified into 2groups based on median PNI value. Results: Median age was 52.5 (18-86) years. There were 49 male and 37 female patients. Most common histology wasliposarcoma (26.7%). Our cohort mainly included stage 3 (69.8%) and grade 3 (66.3%) tumors. Radiotherapy and chemotherapy were applied to 69.8% and 48.8% of patients, respectively. Median value of PNI was 48.2 (25.5-68.0). Medianfollow-up duration was 25 months (3-120). Median overall survival (OS) was 84.6 months (95% CI, 72.0-97.3). MedianOS of patients with high PNI (≥48.2) was significantly longer than patients with low PNI (<48.2), being 99.6 months(95%CI, 83.6-115.6) and 64.5 months(95% CI, 50.3-78.7), respectively(p=0.02). Multivariate analysis determined PNI as anindependent prognostic indicator for OS [HR: 2.96, (95% CI 1.11–7.87), p=0.02] along with age. Conclusion: Our findings suggest that PNI predicts OS independently in patients with STS. Therefore, PNI is a valuableprognostic tool in preoperative setting.

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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	TELLİ T, SARIYER N, Alan O, Demircan N, ışık s, ARIKAN R, BAŞOĞLU T, YAŞAR A, çelebi a, SOFULLU Ö, EROL B, TÜRKÖZ H, ÖZGEN Z, ERCELEP Ö, Dane F, YUMUK P (2021). Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. , 256 - 262. 10.14744/ejmo.2021.74738
Chicago	TELLİ Tuğba AKIN,SARIYER Nisanur,Alan Ozkan,Demircan Nazım Can,ışık selver,ARIKAN Rukiye,BAŞOĞLU Tuğba,YAŞAR Alper,çelebi abdussamet,SOFULLU Ömer,EROL Bülent,TÜRKÖZ Hüseyin Kemal,ÖZGEN Zerrin,ERCELEP Özlem,Dane Faysal,YUMUK Perran Fulden Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. (2021): 256 - 262. 10.14744/ejmo.2021.74738
MLA	TELLİ Tuğba AKIN,SARIYER Nisanur,Alan Ozkan,Demircan Nazım Can,ışık selver,ARIKAN Rukiye,BAŞOĞLU Tuğba,YAŞAR Alper,çelebi abdussamet,SOFULLU Ömer,EROL Bülent,TÜRKÖZ Hüseyin Kemal,ÖZGEN Zerrin,ERCELEP Özlem,Dane Faysal,YUMUK Perran Fulden Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. , 2021, ss.256 - 262. 10.14744/ejmo.2021.74738
AMA	TELLİ T,SARIYER N,Alan O,Demircan N,ışık s,ARIKAN R,BAŞOĞLU T,YAŞAR A,çelebi a,SOFULLU Ö,EROL B,TÜRKÖZ H,ÖZGEN Z,ERCELEP Ö,Dane F,YUMUK P Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. . 2021; 256 - 262. 10.14744/ejmo.2021.74738
Vancouver	TELLİ T,SARIYER N,Alan O,Demircan N,ışık s,ARIKAN R,BAŞOĞLU T,YAŞAR A,çelebi a,SOFULLU Ö,EROL B,TÜRKÖZ H,ÖZGEN Z,ERCELEP Ö,Dane F,YUMUK P Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. . 2021; 256 - 262. 10.14744/ejmo.2021.74738
IEEE	TELLİ T,SARIYER N,Alan O,Demircan N,ışık s,ARIKAN R,BAŞOĞLU T,YAŞAR A,çelebi a,SOFULLU Ö,EROL B,TÜRKÖZ H,ÖZGEN Z,ERCELEP Ö,Dane F,YUMUK P "Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma." , ss.256 - 262, 2021. 10.14744/ejmo.2021.74738
ISNAD	TELLİ, Tuğba AKIN vd. "Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma". (2021), 256-262. https://doi.org/10.14744/ejmo.2021.74738

APA	TELLİ T, SARIYER N, Alan O, Demircan N, ışık s, ARIKAN R, BAŞOĞLU T, YAŞAR A, çelebi a, SOFULLU Ö, EROL B, TÜRKÖZ H, ÖZGEN Z, ERCELEP Ö, Dane F, YUMUK P (2021). Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. Eurasian Journal of Medical Investigation, 5(2), 256 - 262. 10.14744/ejmo.2021.74738
Chicago	TELLİ Tuğba AKIN,SARIYER Nisanur,Alan Ozkan,Demircan Nazım Can,ışık selver,ARIKAN Rukiye,BAŞOĞLU Tuğba,YAŞAR Alper,çelebi abdussamet,SOFULLU Ömer,EROL Bülent,TÜRKÖZ Hüseyin Kemal,ÖZGEN Zerrin,ERCELEP Özlem,Dane Faysal,YUMUK Perran Fulden Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. Eurasian Journal of Medical Investigation 5, no.2 (2021): 256 - 262. 10.14744/ejmo.2021.74738
MLA	TELLİ Tuğba AKIN,SARIYER Nisanur,Alan Ozkan,Demircan Nazım Can,ışık selver,ARIKAN Rukiye,BAŞOĞLU Tuğba,YAŞAR Alper,çelebi abdussamet,SOFULLU Ömer,EROL Bülent,TÜRKÖZ Hüseyin Kemal,ÖZGEN Zerrin,ERCELEP Özlem,Dane Faysal,YUMUK Perran Fulden Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. Eurasian Journal of Medical Investigation, vol.5, no.2, 2021, ss.256 - 262. 10.14744/ejmo.2021.74738
AMA	TELLİ T,SARIYER N,Alan O,Demircan N,ışık s,ARIKAN R,BAŞOĞLU T,YAŞAR A,çelebi a,SOFULLU Ö,EROL B,TÜRKÖZ H,ÖZGEN Z,ERCELEP Ö,Dane F,YUMUK P Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. Eurasian Journal of Medical Investigation. 2021; 5(2): 256 - 262. 10.14744/ejmo.2021.74738
Vancouver	TELLİ T,SARIYER N,Alan O,Demircan N,ışık s,ARIKAN R,BAŞOĞLU T,YAŞAR A,çelebi a,SOFULLU Ö,EROL B,TÜRKÖZ H,ÖZGEN Z,ERCELEP Ö,Dane F,YUMUK P Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma. Eurasian Journal of Medical Investigation. 2021; 5(2): 256 - 262. 10.14744/ejmo.2021.74738
IEEE	TELLİ T,SARIYER N,Alan O,Demircan N,ışık s,ARIKAN R,BAŞOĞLU T,YAŞAR A,çelebi a,SOFULLU Ö,EROL B,TÜRKÖZ H,ÖZGEN Z,ERCELEP Ö,Dane F,YUMUK P "Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma." Eurasian Journal of Medical Investigation, 5, ss.256 - 262, 2021. 10.14744/ejmo.2021.74738
ISNAD	TELLİ, Tuğba AKIN vd. "Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma". Eurasian Journal of Medical Investigation 5/2 (2021), 256-262. https://doi.org/10.14744/ejmo.2021.74738