Objective: Our objective was to investigate the most common anomalies in our region with a retrospective evaluation of the congenital anomaly cases, who applied to the outpatient department of perinatology Material and Method: We was reviewed file of congenital anomaly cases, who applied to the outpatient department of perinatology in the Medical Faculty at Ondokuz Mayıs University between May 2014 and May 2019,and to determine the risk factors related to these anomalies. Seven hundred twenty-five pregnant women, whose infants were diagnosed with congenital anomalies in our center, were included in the present study. Parameters like the mother’s age, consanguineous parents, history of previous habitual abortions, history of siblings with anomalies, number of parity and abortus history, gestational week at diagnosis, smoking, alcohol and drug consumption in the first trimester, periconceptional folic acid use, co-morbidities, ultrasonographic findings, presence of the karyotype analysis, double and triple screening tests, termination decisions were compared with the anomaly types. Results: In our study, we determined the incidence of anomalies in our region with some limitations. Except for the central nervous system anomalies (most common anomaly group), the incidence ranking of the anomalies in our region was different from the rankings reported in other national studies The CVS anomalies were the second most common anomaly group. Conclusion: An education program prepared for the pregnant women in our region about the goal of the diagnostic and screening tests and routine pregnancy controls will increase the chance of early diagnosis. We believe that the conduction of region-based prenatal and postnatal studies instead of hospital-based studies will contribute more to a clear understanding of the anomaly incidences in our region