The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins
Yıl: 2021 Cilt: 49 Sayı: 7 Sayfa Aralığı: 536 - 544 Metin Dili: İngilizce DOI: 10.5543/tkda.2021.11292 İndeks Tarihi: 29-01-2022
The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins
Öz: Objective: Myocardial injury related to percutaneous coronary interventions (PCI) might adversely affect the prognosis of patients with coronary artery disease. Our study aimed to investigate the effects of long-term statin usage on myocardial injury related to elective PCI. Methods: In our study, total 102 patients were included and evaluated in 3 groups based on the statin usage before PCI, “potent statin” group (n=26), “weak statin” group (n=23), and “statin free” group (n=53). The occurrence of the procedural complications was identified (n=31). The myocardial injury was determined by serial high-sensitivity troponin T (hsTnT) testing at 0th, 2nd, 4th, and 12th hour of the procedure. Results: The increase in hsTnT values in the 2nd and 4th hour was significantly lower in the potent statin group than in the other 2 groups (p=0.008 and p=0.009, respectively). In patients with procedural complications, the increase in hsTnT levels at the 2nd, 4th, and 12th hour were also lower in the potent statin group (p=0.032, p=0.019, and p=0.006, respectively). Also, in patients with procedural complications, hsTnT levels exceeding the myocardial infarction limit at the 4th and 12th hour were lower in the potent statin group (p=0.039 and p=0.006, respectively). Conclusion: These results show that elective PCI related myocardial injury was less frequent in patients who were using high-dose statins. This result was more pronounced in patients who developed complications during the procedure.
Anahtar Kelime: Yüksek duyarlılıklı troponin ile değerlendirilen perkütan koroner girişime bağlı miyokart hasarının statin kullanımıyla ilişkisi
Öz: Amaç: Perkütan koroner girişimler (PKG) ilişkili miyokardiyal hasar, koroner arter hastalığı olan hastaların prognozunu olumsuz etkileyebilir. Çalışmamızın amacı, uzun süreli statin kullanımının elektif PKG ile ilişkili miyokardiyal hasar üzerine etkilerini araştırmaktır. Yöntemler: Çalışmamıza toplam 102 hasta dahil edildi ve PKG öncesi statin kullanımına göre üç grupta değerlendirildi, ‘’potent statin’’ grubu (n=26), ‘’zayıf statin’’ grubu (n=23) ve ‘’statin içermeyen’’ grubu (n=53). PKG sırasında komplikasyonu gelişen hastalar belirlendi (n=31). Miyokardiyal hasar, işlemin 0, 2, 4 ve 12. saatlerinde seri yüksek duyarlılıklı troponin T (hsTnT) testi ile belirlendi. Bulgular: Potent statin grubunda 2. ve 4. saatlerde hsTnT değerlerindeki artış diğer iki gruba göre anlamlı olarak daha düşüktü (sırasıyla p=0.008 ve 0.009). Prosedürel komplikasyon yaşanan hastalarda 2., 4. ve 12. saatlerde hsTnT düzeylerindeki artış potent statin grubunda diğer iki gruba göre daha düşüktü (sırasıyla p=0.032, 0.019 ve 0.006). Ayrıca işlem sırasında komplikasyon yaşanan hastalarda, potent statin grubunda 4. ve 12. saatlerde hsTnT düzeyleri miyokart enfarktüsü sınırını aşan hastalar daha azdı. (p=0.039 ve p=0.006, sırasıyla). Sonuç: Bu sonuçlar, yüksek doz statin kullanan hastalarda elektif PKG ile ilişkili miyokardiyal hasarın daha az sıklıkta olduğunu göstermektedir. İşlem sırasında komplikasyon gelişen hastalarda bu sonuç daha belirgindi.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Koçak A, Ünlü S, GÖKALP G, YILMAZ N, Gülbahar Ö, ABACI A (2021). The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. , 536 - 544. 10.5543/tkda.2021.11292 |
| Chicago | Koçak Ajar,Ünlü Serkan,GÖKALP GÖKHAN,YILMAZ NIYAZI SAMET,Gülbahar Özlem,ABACI ADNAN The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. (2021): 536 - 544. 10.5543/tkda.2021.11292 |
| MLA | Koçak Ajar,Ünlü Serkan,GÖKALP GÖKHAN,YILMAZ NIYAZI SAMET,Gülbahar Özlem,ABACI ADNAN The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. , 2021, ss.536 - 544. 10.5543/tkda.2021.11292 |
| AMA | Koçak A,Ünlü S,GÖKALP G,YILMAZ N,Gülbahar Ö,ABACI A The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. . 2021; 536 - 544. 10.5543/tkda.2021.11292 |
| Vancouver | Koçak A,Ünlü S,GÖKALP G,YILMAZ N,Gülbahar Ö,ABACI A The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. . 2021; 536 - 544. 10.5543/tkda.2021.11292 |
| IEEE | Koçak A,Ünlü S,GÖKALP G,YILMAZ N,Gülbahar Ö,ABACI A "The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins." , ss.536 - 544, 2021. 10.5543/tkda.2021.11292 |
| ISNAD | Koçak, Ajar vd. "The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins". (2021), 536-544. https://doi.org/10.5543/tkda.2021.11292 |
| APA | Koçak A, Ünlü S, GÖKALP G, YILMAZ N, Gülbahar Ö, ABACI A (2021). The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. Türk Kardiyoloji Derneği Arşivi, 49(7), 536 - 544. 10.5543/tkda.2021.11292 |
| Chicago | Koçak Ajar,Ünlü Serkan,GÖKALP GÖKHAN,YILMAZ NIYAZI SAMET,Gülbahar Özlem,ABACI ADNAN The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. Türk Kardiyoloji Derneği Arşivi 49, no.7 (2021): 536 - 544. 10.5543/tkda.2021.11292 |
| MLA | Koçak Ajar,Ünlü Serkan,GÖKALP GÖKHAN,YILMAZ NIYAZI SAMET,Gülbahar Özlem,ABACI ADNAN The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. Türk Kardiyoloji Derneği Arşivi, vol.49, no.7, 2021, ss.536 - 544. 10.5543/tkda.2021.11292 |
| AMA | Koçak A,Ünlü S,GÖKALP G,YILMAZ N,Gülbahar Ö,ABACI A The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. Türk Kardiyoloji Derneği Arşivi. 2021; 49(7): 536 - 544. 10.5543/tkda.2021.11292 |
| Vancouver | Koçak A,Ünlü S,GÖKALP G,YILMAZ N,Gülbahar Ö,ABACI A The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins. Türk Kardiyoloji Derneği Arşivi. 2021; 49(7): 536 - 544. 10.5543/tkda.2021.11292 |
| IEEE | Koçak A,Ünlü S,GÖKALP G,YILMAZ N,Gülbahar Ö,ABACI A "The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins." Türk Kardiyoloji Derneği Arşivi, 49, ss.536 - 544, 2021. 10.5543/tkda.2021.11292 |
| ISNAD | Koçak, Ajar vd. "The relationship between long-term statin usage and myocardial injury related to percutaneous coronary interventions evaluated by high-sensitivity troponins". Türk Kardiyoloji Derneği Arşivi 49/7 (2021), 536-544. https://doi.org/10.5543/tkda.2021.11292 |
