Yıl: 2021 Cilt: 45 Sayı: 2 Sayfa Aralığı: 354 - 362 Metin Dili: İngilizce DOI: 10.3906/vet-2007-68 İndeks Tarihi: 31-01-2022

IGF-1 and GH alterations in lambs with intestinal inflammation

Öz:
Abstract: Insulin-like growth factor-1 (IGF-1) acts on the development of internal organs such as the small intestine and muscle in all animal species. Similar to IGF-1, GH is also essential for growth and is an effective hormone on intestinal development during neonatal period. The aim of this study was to investigate the effects of diarrhea on IGF-1 and GH hormones in lambs with intestinal inflammation up to 63 days of age. The study material consisted of 15 healthy and 15 diarrheic lambs. Blood and fecal samples were collected on the first day of life and on the 7th, 14th, 21st, 35th, 49th and 63rd postnatal days consecutively. Diarrhea was observed on 6 animals on the 7th day and 9 animals on 14th day visitation. IGF-1 showed statistically significant differences (P < 0.01) between diarrheic and healthy animals on all measurement days. A significant association was found between the cut-off values determined after ROC analysis of the 7th day (Sens: 93.33%, Spec: 66.67%, P = 0.004) and 14th day (Sens: 73.33%, Spec: 80%, P = 0.0002) values of IGF-1 and diarrhea. Considering 14th day of IGF-1, a logistic regression analysis was performed, the risk of diarrhea is OR = 7.00 times higher if the concentration of the parameter is above the cut-off value. ROC analysis also showed significant cut-off values for GH on 14th day. In terms of sensitivity, the highest value was IGF-1’s 7th day value, therefore it can be preferred for the determination of intestinal inflammation in cases with diarrhea. As a general evaluation, it is seen that the highest performance was given by the 7th day IGF-1 values according to the Youden’s J index. In conclusion, elevations in IGF-1 and GH concentrations may be associated with intestinal inflammation. The inducing effect of the inflammatory response on IGF-I and GH may strengthen the relationship between the two parameters.Key words: Lamb, diarrhea, cryptosporidium, IGF-1, growth hormone
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APA Temizel E, Karakuş A, Kavukcu F, UDUM D, Ercan I (2021). IGF-1 and GH alterations in lambs with intestinal inflammation. , 354 - 362. 10.3906/vet-2007-68
Chicago Temizel Ethem Mutlu,Karakuş Adil Ömer,Kavukcu Fatih,UDUM DUYGU,Ercan Ilker IGF-1 and GH alterations in lambs with intestinal inflammation. (2021): 354 - 362. 10.3906/vet-2007-68
MLA Temizel Ethem Mutlu,Karakuş Adil Ömer,Kavukcu Fatih,UDUM DUYGU,Ercan Ilker IGF-1 and GH alterations in lambs with intestinal inflammation. , 2021, ss.354 - 362. 10.3906/vet-2007-68
AMA Temizel E,Karakuş A,Kavukcu F,UDUM D,Ercan I IGF-1 and GH alterations in lambs with intestinal inflammation. . 2021; 354 - 362. 10.3906/vet-2007-68
Vancouver Temizel E,Karakuş A,Kavukcu F,UDUM D,Ercan I IGF-1 and GH alterations in lambs with intestinal inflammation. . 2021; 354 - 362. 10.3906/vet-2007-68
IEEE Temizel E,Karakuş A,Kavukcu F,UDUM D,Ercan I "IGF-1 and GH alterations in lambs with intestinal inflammation." , ss.354 - 362, 2021. 10.3906/vet-2007-68
ISNAD Temizel, Ethem Mutlu vd. "IGF-1 and GH alterations in lambs with intestinal inflammation". (2021), 354-362. https://doi.org/10.3906/vet-2007-68
APA Temizel E, Karakuş A, Kavukcu F, UDUM D, Ercan I (2021). IGF-1 and GH alterations in lambs with intestinal inflammation. Turkish Journal of Veterinary and Animal Sciences, 45(2), 354 - 362. 10.3906/vet-2007-68
Chicago Temizel Ethem Mutlu,Karakuş Adil Ömer,Kavukcu Fatih,UDUM DUYGU,Ercan Ilker IGF-1 and GH alterations in lambs with intestinal inflammation. Turkish Journal of Veterinary and Animal Sciences 45, no.2 (2021): 354 - 362. 10.3906/vet-2007-68
MLA Temizel Ethem Mutlu,Karakuş Adil Ömer,Kavukcu Fatih,UDUM DUYGU,Ercan Ilker IGF-1 and GH alterations in lambs with intestinal inflammation. Turkish Journal of Veterinary and Animal Sciences, vol.45, no.2, 2021, ss.354 - 362. 10.3906/vet-2007-68
AMA Temizel E,Karakuş A,Kavukcu F,UDUM D,Ercan I IGF-1 and GH alterations in lambs with intestinal inflammation. Turkish Journal of Veterinary and Animal Sciences. 2021; 45(2): 354 - 362. 10.3906/vet-2007-68
Vancouver Temizel E,Karakuş A,Kavukcu F,UDUM D,Ercan I IGF-1 and GH alterations in lambs with intestinal inflammation. Turkish Journal of Veterinary and Animal Sciences. 2021; 45(2): 354 - 362. 10.3906/vet-2007-68
IEEE Temizel E,Karakuş A,Kavukcu F,UDUM D,Ercan I "IGF-1 and GH alterations in lambs with intestinal inflammation." Turkish Journal of Veterinary and Animal Sciences, 45, ss.354 - 362, 2021. 10.3906/vet-2007-68
ISNAD Temizel, Ethem Mutlu vd. "IGF-1 and GH alterations in lambs with intestinal inflammation". Turkish Journal of Veterinary and Animal Sciences 45/2 (2021), 354-362. https://doi.org/10.3906/vet-2007-68