TY  - JOUR
TI  - COVID-19 Disease and Interferon-γ: Has it aProtective Impact on Mortality?
AB  - The complex coincidence of several immunopathological, socio-cultural, and health infrastructure factors may affect theCOVID-19 related mortality among different populations. The impact of the age on disease progression has been confirmedin several studies. Recently limited ecological and clinical studies have sparked controversy among researchers about theprotective impact of the non-specific effect of routinely used Bacille Calmette-Guerin (BCG), Hepatitis A virus (HAV), andinfluenza (Flu) vaccines or their natural infections against COVID-19. In the present study, variables, including BCG vaccina tion coverage, HAV prevalence, and population age distributions, from 59 countries were analyzed to examine their potentialassociation with COVID-19 infection and related mortality rate. Concerning COVID-19 cases/million population (1MP) andmortality, there are significant differences between countries with and without BCG vaccination programs (p-value <0.001).A significant negative correlation between both BCG coverage and HAV prevalence with COVID-19 related mortality wasalso found (r (59)=-0.4, p-value <0.05), (r (59) =-0.3, p-value <0.01). Based on the results of the present study, previousecological analyses and available epidemiological evidence, along with knowledge of the immune response to BCG, HAV andinfluenza vaccination, as well as COVID-19 infection progression, the current study suggest a hypothesis that IFN-γ inducedimmune response which could be triggered by BCG, HAV, and flu vaccination or natural infections may have a protectiveeffect against COVID-19 related mortality.
AU  - Kamil, Anton Abdulbasah
AU  - ALOUDAL, Mohammad Reza
AU  - HUSSEİNİ, Abbas Ali
DO  - 10.14744/etd.2020.40326
PY  - 2021
JO  - Erciyes Medical Journal
VL  - 43
IS  - 2
SN  - 2149-2247
SP  - 116
EP  - 121
DB  - TRDizin
UR  - http://search/yayin/detay/486766
ER  -