Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

Taşkıran, Deniz; BOSTANCI, Mehmet Ömer; GORKEM, Umit; Inal, Hasan Ali; kan, ozgur

doi:10.5222/MMJ.2021.32549

Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

Ümit GÖRKEM, (Hitit Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Bölümü, Çorum, Türkiye)

ÖZGÜR KAN, (Hitit Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Bölümü, Çorum, Türkiye)

Mehmet Ömer BOSTANCI, (Hitit Üniversitesi, Tıp Fakültesi, Fizyoloji Bölümü, Çorum, Türkiye)

Deniz TAŞKIRAN, (Hitit Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Bölümü, Çorum, Türkiye)

Hasan Ali İNAL (Konya Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum, Konya, Türkiye)

Medeniyet Medical Journal

2 0

Yıl: 2021 Cilt: 36 Sayı: 2 Sayfa Aralığı: 98 - 105 Metin Dili: İngilizce DOI: 10.5222/MMJ.2021.32549 İndeks Tarihi: 02-02-2022

Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

Öz:

Objective: Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester. Method: In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels. Results: There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all) Conclusions: We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy.

Anahtar Kelime:

İlk Trimester Düşükleri İçin Öngörücü Biyobelirteçler Olarak Kisspeptin ve Hematolojik Parametreler

Öz:

Amaç: Spontan abortus, erken gebeliğin en sık görülen komplikasyonudur ve tanınan gebeliklerin % 20’sini etkilemektedir. Kisspeptin, plasental sinsitiyotrofoblastlar tarafından salınmakta olup rahim matrislerine plasental invazyonu düzenlemektedir. Biz bu çalışmada ilk trimesterin erken gebelik evresindeki gebelik sonuçları ile serum kisspeptin düzeyleri arasında bir ilişki kurmayı amaçladık. Yöntem: Bu prospektif çalışmada, 7-8 6/7 hafta gebelikleri olan doksan gebe toplam üç gruba ayrıldı: (i) sağlıklı gebelerden oluşan kontrol grubu (n=30), (ii) düşük tehdidi grubu (n=30) ve (iii) spontan düşük grubu (n=30). Maternal serum örnekleri, tam kan sayımı parametreleri ve kisspeptin seviyeleri analiz edildi. Bulgular: Vücut kütle indeksi ve gebelik yaşı açısından istatistiksel olarak fark yoktu (p=0.370). Gravida, parite, kürtaj ve yaşayan çocuklar, sosyo-ekonomik düzey ve istihdam dahil olmak üzere ayrıntılı obstetrik durumlarla ilgili olarak çalışma grupları arasında fark yoktu (p>0.05). Nötrofil, lenfosit ve trombosit sayılarının yanı sıra nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR) dahil olmak üzere tam kan sayımının biyokimyasal parametreleri açısından önemli bir ilişki bulunmadı (p>0.05). Çalışma grupları arasında medyan serum kisspeptin seviyeleri anlamlı farklılık göstermedi (p=0.153). Korelasyon analiz testi tüm çalışma gruplarında kisspeptin ile diğer çalışma parametreleri arasında bir korelasyonun olmadığını gösterdi (p>0.05). Sonuç: Bulgularımız, birinci trimesterin erken gebelik evresinde serum kisspeptin konsantrasyonu ile gebelik sonuçları arasında herhangi bir ilişkinin olmadığını ve serum kisspeptin konsantrasyo- nunun düşük durumunu canlı gebeliklerden ayırt etmek için güvenilir bir belirteç olmadığını göstermiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GORKEM U, kan o, BOSTANCI M, Taşkıran D, Inal H (2021). Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. , 98 - 105. 10.5222/MMJ.2021.32549
Chicago	GORKEM Umit,kan ozgur,BOSTANCI Mehmet Ömer,Taşkıran Deniz,Inal Hasan Ali Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. (2021): 98 - 105. 10.5222/MMJ.2021.32549
MLA	GORKEM Umit,kan ozgur,BOSTANCI Mehmet Ömer,Taşkıran Deniz,Inal Hasan Ali Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. , 2021, ss.98 - 105. 10.5222/MMJ.2021.32549
AMA	GORKEM U,kan o,BOSTANCI M,Taşkıran D,Inal H Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. . 2021; 98 - 105. 10.5222/MMJ.2021.32549
Vancouver	GORKEM U,kan o,BOSTANCI M,Taşkıran D,Inal H Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. . 2021; 98 - 105. 10.5222/MMJ.2021.32549
IEEE	GORKEM U,kan o,BOSTANCI M,Taşkıran D,Inal H "Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions." , ss.98 - 105, 2021. 10.5222/MMJ.2021.32549
ISNAD	GORKEM, Umit vd. "Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions". (2021), 98-105. https://doi.org/10.5222/MMJ.2021.32549

APA	GORKEM U, kan o, BOSTANCI M, Taşkıran D, Inal H (2021). Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. Medeniyet Medical Journal, 36(2), 98 - 105. 10.5222/MMJ.2021.32549
Chicago	GORKEM Umit,kan ozgur,BOSTANCI Mehmet Ömer,Taşkıran Deniz,Inal Hasan Ali Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. Medeniyet Medical Journal 36, no.2 (2021): 98 - 105. 10.5222/MMJ.2021.32549
MLA	GORKEM Umit,kan ozgur,BOSTANCI Mehmet Ömer,Taşkıran Deniz,Inal Hasan Ali Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. Medeniyet Medical Journal, vol.36, no.2, 2021, ss.98 - 105. 10.5222/MMJ.2021.32549
AMA	GORKEM U,kan o,BOSTANCI M,Taşkıran D,Inal H Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. Medeniyet Medical Journal. 2021; 36(2): 98 - 105. 10.5222/MMJ.2021.32549
Vancouver	GORKEM U,kan o,BOSTANCI M,Taşkıran D,Inal H Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions. Medeniyet Medical Journal. 2021; 36(2): 98 - 105. 10.5222/MMJ.2021.32549
IEEE	GORKEM U,kan o,BOSTANCI M,Taşkıran D,Inal H "Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions." Medeniyet Medical Journal, 36, ss.98 - 105, 2021. 10.5222/MMJ.2021.32549
ISNAD	GORKEM, Umit vd. "Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions". Medeniyet Medical Journal 36/2 (2021), 98-105. https://doi.org/10.5222/MMJ.2021.32549