TY  - JOUR
TI  - Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress
AB  - Objectives: Oxidative stress has a central role in metabolic disorders associated with high-carbohydrate, ani mal-based-protein diets, and excessive fat consumption. However, the molecular mechanisms of nutrition-mediatedoxidative stress are complex and not fully understood. Dynamic thiol-disulfide homeostasis (DTDH) is the regulationof a balance between thiols and their oxidized forms, and includes the reversal of thiol oxidation in proteins. This studywas an evaluation of DTDH and postprandial oxidative stress. Methods: A total of 86 participants (43 males and 43 females), were included in the study. Fasting and non-fastingblood samples were collected and the native thiol, total thiol, and disulfide parameters were analyzed. Statistical anal yses were performed using IBM SPSS Statistics for Windows, Version 22.0 (IBM Corp., Armonk, NY, USA). Results: The findings indicated that while the native thiol values were significantly lower in the postprandial samples,the disulfide values were significantly higher. There was no significant difference in the total thiol values. Conclusion: Examination of the DTDH revealed that the oxidative stress level increased following food intake. Proteinthiols involved in antioxidant defense were oxidized and transformed into disulfides.
AU  - EREL, Ozcan
AU  - Özbek, Betül
AU  - KOCA, CEMILE
AU  - BALIK, Ahmet Rıfat
AU  - Yilmaz, Gulsen
AU  - Ersoy, Reyhan
DO  - 10.14744/ijmb.2021.53825
PY  - 2021
JO  - International Journal of Medical Biochemistry
VL  - 4
IS  - 3
SN  - 2587-2362
SP  - 185
EP  - 191
DB  - TRDizin
UR  - http://search/yayin/detay/487368
ER  -