Objective: The present research aims to evaluate the relationship between blood groups and COVID-19 patients. Materials and Methods: This is a descriptive study, and data of 256 patients with COVID-19 positive were evaluated. Inthe analysis, the level of statistical significance was accepted as p<0.05. Results: In this research, 62.1% of the patients examined were male, 75.4% were married; 34.8% were in the 30–39 agegroup, 23.8% were in the 40–49 age group, and the mean age was 37.0±12.2. 33.3% of the patients were high schoolgraduates, 32.9% were primary school graduates, 44.1% had blood group A Rh+, and 21.5% had blood group 0 Rh+. Inthis research, the findings showed that 85.9% of the patients had symptoms, 49.6% had malaise, 48.0% had joint pain,32.0% had a history of a positive family member or a positive relative before themselves, and 42.2% had a history of positivecase at the workplace before themselves. Conclusion: In this research, the frequency of the blood group A Rh+ was high and the frequency of the blood group 0 Rh+was low in COVID-19 patients. The mean age of the patients was 37, and number of the patients who needed intensive carewas low. There was no difference between the symptom states, according to blood groups. It is recommended that peoplewith blood type A behave more sensitively in terms of following the protection measures.