Yıl: 2021 Cilt: 43 Sayı: 2 Sayfa Aralığı: 152 - 155 Metin Dili: İngilizce DOI: 10.14744/etd.2020.14477 İndeks Tarihi: 05-02-2022

Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit

Öz:
Objective: Patients with hematologic diseases can have increased life expectancy with newly developed chemotherapeuticagents, hematopoietic stem-cell transplantation, and further supportive therapy. However, intensive therapies lead to morelife-threatening complications that require intensive care unit (ICU) admission. Therefore, understanding the factors affectingmortality is important when accepting these patients to the ICU. This study was conducted to explore the factors affectingthe mortality of patients admitted to medical ICUs with a diagnosis of hematologic disease. Materials and Methods: The medical records of patients with diagnoses of hematologic diseases hospitalized in the medicalICU between March 2013 and March 2019 were retrospectively reviewed. Age, gender, subgroup of hematologic disease,APACHE II scores, admission diagnoses, mechanical ventilation requirement, renal replacement therapy, vasopressor thera py, and ICU and hospital outcomes were recorded. The factors affecting mortality were evaluated. Results: Patients with acute leukemia [29 (30%)], multiple myeloma [20 (21%)], lymphoma [22 (23%)], chronic leukemia [8(9%)], and other hematologic diseases [15 (16%)] were identified and included during the 6-year study period. The medianage of patients was 60 (27.5) years, and 50 (53%) patients were women. Bone marrow transplantation was performed in20% of patients, and 75 (79%) patients required invasive mechanical ventilation. Vasopressor treatment was required in 49(52%) of patients. The mortality rate was 55%. APACHE II scores were higher in nonsurvivors. Moreover, they requiredmore mechanical ventilation, vasopressor treatment, and renal replacement therapy. According to regression analysis, highAPACHE II scores, vasopressor therapy requirement, and presence of respiratory failure were the risk factors for mortality. Conclusion: High APACHE II scores, need for vasopressor therapy, and respiratory failure were identified as independentrisk factors for mortality in patients with hematologic diseases admitted to the medical ICU.
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  • 1. Jones DS, Podolsky SH, Greene JA. The burden of disease and the changing task of medicine. N Engl J Med 2012; 366(25): 2333–8.
  • 2. Azoulay E, Mokart D, Pène F, Lambert J, Kouatchet A, Mayaux J, et al. Outcomes of critically ill patients with hematologic malignancies: prospective multicenter data from France and Belgium--a groupe de recherche respiratoire en réanimation onco-hématologique study. J Clin Oncol 2013; 31(22): 2810–8.
  • 3. Ehooman F, Biard L, Lemiale V, Contou D, de Prost N, Mokart D, et al. Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study. Ann Intensive Care 2019; 9(1): 2.
  • 4. Azoulay E, Soares M, Darmon M, Benoit D, Pastores S, Afessa B. Intensive care of the cancer patient: recent achievements and remaining challenges. Ann Intensive Care 2011; 1(1): 5.
  • 5. Taccone FS, Artigas AA, Sprung CL, Moreno R, Sakr Y, Vincent JL. Characteristics and outcomes of cancer patients in European ICUs. Crit Care 2009; 13(1): R15.
  • 6. Yau E, Rohatiner AZ, Lister TA, Hinds CJ. Long term prognosis and quality of life following intensive care for life-threatening complications of haematological malignancy. Br J Cancer 1991; 64(5): 938–42.
  • 7. Yeo CD, Kim JW, Kim SC, Kim YK, Kim KH, Kim HJ, et al. Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit. J Crit Care 2012; 27(6): 739.e1–6.
  • 8. Alp E, Tok T, Kaynar L, Cevahir F, Akbudak İH, Gündoğan K, et al. Outcomes for haematological cancer patients admitted to an intensive care unit in a university hospital. Aust Crit Care 2018; 31(6): 363–8.
  • 9. Grgić Medić M, Gornik I, Gašparović V. Hematologic malignancies in the medical intensive care unit--Outcomes and prognostic factors. Hematology 2015; 20(5): 247–53.
  • 10. Namendys-Silva SA, González-Herrera MO, García-Guillén FJ, Texcocano-Becerra J, Herrera-Gómez A. Outcome of critically ill patients with hematological malignancies. Ann Hematol 2013; 92(5): 699– 705.
  • 11. Benoit DD, Vandewoude KH, Decruyenaere JM, Hoste EA, Colardyn FA. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med 2003; 31(1): 104–12.
  • 12. Bird GT, Farquhar-Smith P, Wigmore T, Potter M, Gruber PC. Outcomes and prognostic factors in patients with haematological malignancy admitted to a specialist cancer intensive care unit: a 5 yr study. Br J Anaesth 2012; 108(3): 452–9.
  • 13. de Vries VA, Müller MCA, Arbous MS, Biemond BJ, Blijlevens NMA, Kusadasi N, et al; HEMA-ICU Study Group. Long-Term Outcome of Patients With a Hematologic Malignancy and Multiple Organ Failure Admitted at the Intensive Care. Crit Care Med 2019; 47(2): e120–8.
  • 14. Boyacı N, Aygencel G, Turkoglu M, Yegin ZA, Acar K, Sucak GT. The intensive care management process in patients with hematopoietic stem cell transplantation and factors affecting their prognosis. Hematology 2014; 19(6): 338–45.
  • 15. Cornish M, Butler MB, Green RS. Predictors of Poor Outcomes in Critically Ill Adults with Hematologic Malignancy. Can Respir J 2016; 2016: 9431385.
  • 16. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care 2009; 13(4): R137.
APA Ferlicolak L, ALTINTAŞ N (2021). Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. , 152 - 155. 10.14744/etd.2020.14477
Chicago Ferlicolak Leyla,ALTINTAŞ Neriman Defne Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. (2021): 152 - 155. 10.14744/etd.2020.14477
MLA Ferlicolak Leyla,ALTINTAŞ Neriman Defne Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. , 2021, ss.152 - 155. 10.14744/etd.2020.14477
AMA Ferlicolak L,ALTINTAŞ N Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. . 2021; 152 - 155. 10.14744/etd.2020.14477
Vancouver Ferlicolak L,ALTINTAŞ N Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. . 2021; 152 - 155. 10.14744/etd.2020.14477
IEEE Ferlicolak L,ALTINTAŞ N "Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit." , ss.152 - 155, 2021. 10.14744/etd.2020.14477
ISNAD Ferlicolak, Leyla - ALTINTAŞ, Neriman Defne. "Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit". (2021), 152-155. https://doi.org/10.14744/etd.2020.14477
APA Ferlicolak L, ALTINTAŞ N (2021). Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. Erciyes Medical Journal, 43(2), 152 - 155. 10.14744/etd.2020.14477
Chicago Ferlicolak Leyla,ALTINTAŞ Neriman Defne Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. Erciyes Medical Journal 43, no.2 (2021): 152 - 155. 10.14744/etd.2020.14477
MLA Ferlicolak Leyla,ALTINTAŞ Neriman Defne Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. Erciyes Medical Journal, vol.43, no.2, 2021, ss.152 - 155. 10.14744/etd.2020.14477
AMA Ferlicolak L,ALTINTAŞ N Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. Erciyes Medical Journal. 2021; 43(2): 152 - 155. 10.14744/etd.2020.14477
Vancouver Ferlicolak L,ALTINTAŞ N Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit. Erciyes Medical Journal. 2021; 43(2): 152 - 155. 10.14744/etd.2020.14477
IEEE Ferlicolak L,ALTINTAŞ N "Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit." Erciyes Medical Journal, 43, ss.152 - 155, 2021. 10.14744/etd.2020.14477
ISNAD Ferlicolak, Leyla - ALTINTAŞ, Neriman Defne. "Factors Affecting Mortality in Hematology PatientsAccepted to the Intensive Care Unit". Erciyes Medical Journal 43/2 (2021), 152-155. https://doi.org/10.14744/etd.2020.14477