TY  - JOUR
TI  - Type 2B Von Willebrand Disease MimickingAutoimmune Thrombocytopenia in the Neonatal Period
AB  - Background: Type 2B von Willebrand disease (VWD) is a hereditary bleeding disorder caused by changes in the von Will ebrand factor (VWF), which increases the binding of VWF to platelets. Type 2B VWD may present with thrombocytopenia. Case Report: A four-day-old newborn was brought to the neonatal intensive care unit presenting with bleeding and severethrombocytopenia. The platelet level was 10,000/mm3, and coagulation tests were normal. There were no clinical evidenceof sepsis; therefore, alloimmune or autoimmune thrombocytopenia was suspected. When we found out that her motherand relatives had intermittent thrombocytopenia, advanced tests were performed. Ristocetin cofactor activity was low; type2 VWD was considered. Using low-dose ristocetin, we increased platelet aggregation. Heterozygous c.3946G > A (p.Val 1316Met) mutation was detected, and type 2B VWD was diagnosed. Conclusion: Type 2B VWD may cause a diagnostic problem in the differential diagnosis of neonatal thrombocytopeniaincluding neonatal autoimmune thrombocytopenia.
AU  - ATİK, Tahir
AU  - ÖZCAN, Alper
AU  - Yılmaz, Ebru
AU  - isik, esra
AU  - Patıroglu, Türkan
AU  - UNAL, Ekrem
AU  - KARAKÜKÇÜ, Musa
AU  - AYDIN, Firdevs
AU  - gök, veysel
DO  - 10.14744/etd.2020.81557
PY  - 2021
JO  - Erciyes Medical Journal
VL  - 43
IS  - 2
SN  - 2149-2247
SP  - 201
EP  - 203
DB  - TRDizin
UR  - http://search/yayin/detay/487949
ER  -