A Transgenerational Genetic Marker of the AutismSpectrum Disorder

TAHER, Serpil; ÖZKUL, Yusuf; CUZİN, François; RASSOULZADEGAN, Minoo

doi:10.14744/etd.2021.65289

A Transgenerational Genetic Marker of the AutismSpectrum Disorder

Minoo RASSOULZADEGAN, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kayseri, Türkiye)

Serpil TAHER, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Kayseri, Türkiye)

François CUZİN, (Université Côte d’Azur, CNRS, Inserm, France)

Yusuf ÖZKUL (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kayseri, Türkiye)

Erciyes Medical Journal

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Yıl: 2021 Cilt: 43 Sayı: 3 Sayfa Aralığı: 214 - 220 Metin Dili: İngilizce DOI: 10.14744/etd.2021.65289 İndeks Tarihi: 06-02-2022

A Transgenerational Genetic Marker of the AutismSpectrum Disorder

Öz:

Autism spectrum disorder (ASD) is an increasingly frequent neurodevelopmental disorder. A number of indications recentlypointed to abnormal distributions of microRNAs (miRNAs) in autistic patients. The noncoding regulatory miRNAs are abun dant in the developing brain and abnormal levels of expression of several of them were found in tissues of ASD patients.Here, we discuss the previously published results and compare them with our recent data identifying 6 miRNAs whose bloodlevels are downregulated in ASD patients. A similar although less pronounced decrease is hereditarily transmitted by theclinically unaffected parents of sick children and the sibling. Robustness of the finding was confirmed by similarly low levels ofthe six microRNAs in two established mouse models of the disease. Several hopeful avenues of research may be consideredfrom these results including molecular mechanisms from the regulation of the miRNAs to the identification of their targetgenes and the non-Mendelian mode of inheritance of the autism-prone state. On the clinical side, they offer the possibility ofa very early detection of the affected children.

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APA	RASSOULZADEGAN M, TAHER S, CUZİN F, ÖZKUL Y (2021). A Transgenerational Genetic Marker of the AutismSpectrum Disorder. , 214 - 220. 10.14744/etd.2021.65289
Chicago	RASSOULZADEGAN Minoo,TAHER Serpil,CUZİN François,ÖZKUL Yusuf A Transgenerational Genetic Marker of the AutismSpectrum Disorder. (2021): 214 - 220. 10.14744/etd.2021.65289
MLA	RASSOULZADEGAN Minoo,TAHER Serpil,CUZİN François,ÖZKUL Yusuf A Transgenerational Genetic Marker of the AutismSpectrum Disorder. , 2021, ss.214 - 220. 10.14744/etd.2021.65289
AMA	RASSOULZADEGAN M,TAHER S,CUZİN F,ÖZKUL Y A Transgenerational Genetic Marker of the AutismSpectrum Disorder. . 2021; 214 - 220. 10.14744/etd.2021.65289
Vancouver	RASSOULZADEGAN M,TAHER S,CUZİN F,ÖZKUL Y A Transgenerational Genetic Marker of the AutismSpectrum Disorder. . 2021; 214 - 220. 10.14744/etd.2021.65289
IEEE	RASSOULZADEGAN M,TAHER S,CUZİN F,ÖZKUL Y "A Transgenerational Genetic Marker of the AutismSpectrum Disorder." , ss.214 - 220, 2021. 10.14744/etd.2021.65289
ISNAD	RASSOULZADEGAN, Minoo vd. "A Transgenerational Genetic Marker of the AutismSpectrum Disorder". (2021), 214-220. https://doi.org/10.14744/etd.2021.65289

APA	RASSOULZADEGAN M, TAHER S, CUZİN F, ÖZKUL Y (2021). A Transgenerational Genetic Marker of the AutismSpectrum Disorder. Erciyes Medical Journal, 43(3), 214 - 220. 10.14744/etd.2021.65289
Chicago	RASSOULZADEGAN Minoo,TAHER Serpil,CUZİN François,ÖZKUL Yusuf A Transgenerational Genetic Marker of the AutismSpectrum Disorder. Erciyes Medical Journal 43, no.3 (2021): 214 - 220. 10.14744/etd.2021.65289
MLA	RASSOULZADEGAN Minoo,TAHER Serpil,CUZİN François,ÖZKUL Yusuf A Transgenerational Genetic Marker of the AutismSpectrum Disorder. Erciyes Medical Journal, vol.43, no.3, 2021, ss.214 - 220. 10.14744/etd.2021.65289
AMA	RASSOULZADEGAN M,TAHER S,CUZİN F,ÖZKUL Y A Transgenerational Genetic Marker of the AutismSpectrum Disorder. Erciyes Medical Journal. 2021; 43(3): 214 - 220. 10.14744/etd.2021.65289
Vancouver	RASSOULZADEGAN M,TAHER S,CUZİN F,ÖZKUL Y A Transgenerational Genetic Marker of the AutismSpectrum Disorder. Erciyes Medical Journal. 2021; 43(3): 214 - 220. 10.14744/etd.2021.65289
IEEE	RASSOULZADEGAN M,TAHER S,CUZİN F,ÖZKUL Y "A Transgenerational Genetic Marker of the AutismSpectrum Disorder." Erciyes Medical Journal, 43, ss.214 - 220, 2021. 10.14744/etd.2021.65289
ISNAD	RASSOULZADEGAN, Minoo vd. "A Transgenerational Genetic Marker of the AutismSpectrum Disorder". Erciyes Medical Journal 43/3 (2021), 214-220. https://doi.org/10.14744/etd.2021.65289