TY  - JOUR
TI  - A Transgenerational Genetic Marker of the AutismSpectrum Disorder
AB  - Autism spectrum disorder (ASD) is an increasingly frequent neurodevelopmental disorder. A number of indications recentlypointed to abnormal distributions of microRNAs (miRNAs) in autistic patients. The noncoding regulatory miRNAs are abun dant in the developing brain and abnormal levels of expression of several of them were found in tissues of ASD patients.Here, we discuss the previously published results and compare them with our recent data identifying 6 miRNAs whose bloodlevels are downregulated in ASD patients. A similar although less pronounced decrease is hereditarily transmitted by theclinically unaffected parents of sick children and the sibling. Robustness of the finding was confirmed by similarly low levels ofthe six microRNAs in two established mouse models of the disease. Several hopeful avenues of research may be consideredfrom these results including molecular mechanisms from the regulation of the miRNAs to the identification of their targetgenes and the non-Mendelian mode of inheritance of the autism-prone state. On the clinical side, they offer the possibility ofa very early detection of the affected children.
AU  - TAHER, Serpil
AU  - ÖZKUL, Yusuf
AU  - CUZİN, François
AU  - RASSOULZADEGAN, Minoo
DO  - 10.14744/etd.2021.65289
PY  - 2021
JO  - Erciyes Medical Journal
VL  - 43
IS  - 3
SN  - 2149-2247
SP  - 214
EP  - 220
DB  - TRDizin
UR  - http://search/yayin/detay/488008
ER  -