COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality

sevinc, can; Demirci, Recep; timur, ozge

doi:10.4274/iksstd.2021.80958

COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality

Can SEVİNÇ, (Atatürk Üniversitesi, Tıp Fakültesi, İç Hastalıkları Ana Bilim Dalı, Erzurum, Türkiye)

Özge TİMUR, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Erzurum, Türkiye)

Recep DEMİRCİ (Sağlık Bilimleri Üniversitesi, Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, İstanbul, Türkiye)

İstanbul Kanuni Sultan Süleyman Tıp Dergisi

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Yıl: 2021 Cilt: 13 Sayı: 3 Sayfa Aralığı: 162 - 169 Metin Dili: İngilizce DOI: 10.4274/iksstd.2021.80958 İndeks Tarihi: 07-02-2022

COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality

Öz:

Objective: Globally, coronavirus disease-2019 (COVID-19) has affected the elderly population and patients with multiple comorbid diseases. Hemodialysis (HD) patients are at risk of contracting COVID-19 due to immunosuppression caused by chronic kidney disease, advanced age, and existing comorbid diseases. We retrospectively studied the clinical characteristics of total of 121 HD patients with COVID-19. Method: A total of 121 HD patients who met the COVID-19 probable case definition were included in the study. The patients were divided into groups according to their clinical and laboratory findings: mild-moderate, severe, and critical. Subsequently, the patients were divided into classified as either survivors or nonsurvivors and their demographic and laboratory data were compared. Results: Of the 121 patients, 61 (51%) and 59 (49%) were female and male, respectively. Mean age of the patients was 61 ± 14. The most common comorbid disease among the patients was hypertension, followed by coronary artery disease and diabetes mellitus. The most common complaints were cough, myalgia, and shortness of breath. Conclusion: This study contributes to literature by determining biomarkers to predict mortality due to COVID-19 infection in high-risk and vulnerable HD patient population.

Anahtar Kelime:

Hemodiyaliz Hastalarında COVID-19 Enfeksiyonu: Klinik Özellikler, Sonuçlar ve Mortalite İlişkili Faktörler

Öz:

Amaç: Koronavirüs hastalığı-2019 (COVID-19) enfeksiyonu tüm dünyada, yaşlı popülasyonu ve birçok komorbid hastalığı olan hastaları etkilemiştir. Hemodiyaliz (HD) hastaları, ileri yaş, mevcut komorbid hastalıklar ve kronik böbrek hastalığının, neden olduğu immünosupresyon nedeniyle COVID-19 enfeksiyonu için riski altındadır. Çalışmamızda COVID-19 enfeksiyonu olan 121 HD hastasının klinik özellikleri, sonuçları ve mortalite ile ilişkili faktörleri inceledik. Yöntem: COVID-19 olası olgu tanımına uyan 121 hemodiyaliz hastası çalışmaya dahil edildi. Hastalar klinik ve laboratuvar özelliklerine göre hafif-orta, ağır ve kritik olarak gruplara ayrıldı. Daha sonra hastalar sağ kalanlar ve eksitus olanlar olarak gruplara ayrılarak demografik ve laboratuvar verileri açısından karşılaştırıldı. Bulgular: Çalışmaya 61’i (% 51) kadın, 59’u (%49) erkek olmak üzere toplam 121 hasta dahil edildi. Hastaların ortalama yaşı 61 ± 14 idi. Hastaların en sık eşlik eden komorbid hastalığı hipertansiyon, ardından koroner arter hastalığı ve diabetes mellitus idi. En yaygın şikayetler öksürük, kas ağrısı ve nefes darlığı idi. Sonuç: Bu çalışma, yüksek riskli ve savunmasız HD hasta popülasyonunda COVID-19 enfeksiyonuna bağlı mortaliteyi öngörmek için beyaz kan hücre sayısı, nötrofil sayısı, laktat dehidrogenaz, aspartat transaminaz gibi biyobelirteçlerin kullanımının faydalı olacağını göstermiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard. World Health Organization. 2020. Available from: https:// covid19.who.int/
2. Ozturk S, Turgutalp K, Arici M, et al. Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey. Nephrol Dial Transplant. 2020;35:2083-95.
3. Park HC, Lee YK, Lee SH, et al; Korean Society of Nephrology MERS-CoV Task Force Team. Middle East respiratory syndrome clinical practice guideline for hemodialysis facilities. Kidney Res Clin Pract. 2017;36:111- 6. doi: 10.23876/j.krcp.2017.36.2.111.
4. Collins AJ, Kliger AS. Urgent: stop preventable ınfections Now. Clin J Am Soc Nephrol. 2018;13:663-5. doi: 10.2215/CJN.10790917.
5. Xiong F, Tang H, Liu L, et al. Clinical characteristics of and medical ınterventions for COVID-19 in hemodialysis patients in Wuhan, China. J Am Soc Nephrol. 2020;31:1387-97. doi: 10.1681/ASN.2020030354.
6. Scarpioni R, Manini A, Valsania T, et al. Covid-19 and its impact on nephropathic patients: the experience at Ospedale "Guglielmo da Saliceto" in Piacenza. G Ital Nefrol. 2020;37:2020-vol2.
7. Goicoechea M, Sánchez Cámara LA, Macías N, et al. COVID-19: clinical course and outcomes of 36 hemodialysis patients in Spain. Kidney Int. 2020;98:27-34. doi: 10.1016/j.kint.2020.04.031.
8. Valeri AM, Robbins-Juarez SY, Stevens JS, et al. Presentation and outcomes of patients with ESKD and COVID-19. J Am Soc Nephrol. 2020;Jul;31:1409-15. doi: 10.1681/ASN.2020040470.
9. Guan W, Ni Z, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382:1708-20. doi: 10.1056/ NEJMoa2002032.
10. Chen CY, Shao SC, Chen YT, et al. Incidence and clinical ımpacts of COVID-19 ınfection in patients with hemodialysis: systematic review and meta-analysis of 396,062 hemodialysis patients. Healthcare (Basel). 2021;9:47. doi: 10.3390/healthcare9010047.
11. Stefan G, Mehedinti AM, Andreiana I, et al. Clinical features and outcome of maintenance hemodialysis patients with COVID-19 from a tertiary nephrology care center in Romania. Ren Fail. 2021;4349-57. doi: 10.1080/0886022X.2020.1853571
12. Ma Y, Diao B, Lv X, et al. COVID-19 in hemodialysis (HD) patients: Report from one HD center in Wuhan, China. medRxiv. 2020. doi: 10.1101/2020.02.24.20027201.
13. Shang W, Li Y, Li H, et al. Correlation between laboratory parameters on admission and outcome of COVID-19 in maintenance hemodialysis patients. Int Urol Nephrol. 2021;53:165-9. doi: 10.1007/s11255-020- 02646-0.
14. Szarpak L, Ruetzler K, Safiejko K, et al. Lactate dehydrogenase level as a COVID-19 severity marker. Am J Emerg Med. 2021;45:638-9. doi: 10.1016/j.ajem.2020.11.025.
15. Chen C, Lee C, Liu C, Wang J, Wang L, Perng R. free information in English and Mandarin on the novel coronavirus COVID- Clinical Features and Outcomes of Severe Acute Respiratory Syndrome and Predictive Factors for Acute Respiratory Distress Syndrome. 2020;(January).
16. Henry BM, Aggarwal G, Wong J, et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis. Am J Emerg Med. 2020. doi:10.1016/j.ajem.2020.05.073.
17. Fisher M, Yunes M, Mokrzycki MH, Golestaneh L, Alahiri E, Coco M. Chronic Hemodialysis Patients Hospitalized with COVID-19: Short-term Outcomes in the Bronx, New York: Kidney 360; 2020.
18. Islam M, Ozturk Y, Koc Y. Clinical outcomes of COVID-19 in hemodialysis patients in the city of Zonguldak, Turkey. Int Urol Nephrol. 2021;53:1445- 52. doi: 10.1007/s11255-020-02781-8
19. Oh JS, Choi JS, Lee YH, et al. The relationships between respiratory virus ınfection and aminotransferase in children. Pediatr Gastroenterol Hepatol Nutr. 2016;19:243-50. doi: 10.5223/pghn.2016.19.4.243.
20. Chen LZ, Lin ZH, Chen J, Liu SS, Shi T, Xin YN. Can elevated concentrations of ALT and AST predict the risk of 'recurrence' of COVID-19? Epidemiol Infect. 2020;148:e218. doi: 10.1017/S0950268820002186.
21. Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020;5:428-30. doi: 10.1016/ S2468-1253(20)30057-1.
22. Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020 Mar 31;368:m1295. doi: 10.1136/bmj.m1091.

APA	sevinc c, timur o, Demirci R (2021). COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. , 162 - 169. 10.4274/iksstd.2021.80958
Chicago	sevinc can,timur ozge,Demirci Recep COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. (2021): 162 - 169. 10.4274/iksstd.2021.80958
MLA	sevinc can,timur ozge,Demirci Recep COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. , 2021, ss.162 - 169. 10.4274/iksstd.2021.80958
AMA	sevinc c,timur o,Demirci R COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. . 2021; 162 - 169. 10.4274/iksstd.2021.80958
Vancouver	sevinc c,timur o,Demirci R COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. . 2021; 162 - 169. 10.4274/iksstd.2021.80958
IEEE	sevinc c,timur o,Demirci R "COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality." , ss.162 - 169, 2021. 10.4274/iksstd.2021.80958
ISNAD	sevinc, can vd. "COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality". (2021), 162-169. https://doi.org/10.4274/iksstd.2021.80958

APA	sevinc c, timur o, Demirci R (2021). COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 13(3), 162 - 169. 10.4274/iksstd.2021.80958
Chicago	sevinc can,timur ozge,Demirci Recep COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. İstanbul Kanuni Sultan Süleyman Tıp Dergisi 13, no.3 (2021): 162 - 169. 10.4274/iksstd.2021.80958
MLA	sevinc can,timur ozge,Demirci Recep COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. İstanbul Kanuni Sultan Süleyman Tıp Dergisi, vol.13, no.3, 2021, ss.162 - 169. 10.4274/iksstd.2021.80958
AMA	sevinc c,timur o,Demirci R COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. İstanbul Kanuni Sultan Süleyman Tıp Dergisi. 2021; 13(3): 162 - 169. 10.4274/iksstd.2021.80958
Vancouver	sevinc c,timur o,Demirci R COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality. İstanbul Kanuni Sultan Süleyman Tıp Dergisi. 2021; 13(3): 162 - 169. 10.4274/iksstd.2021.80958
IEEE	sevinc c,timur o,Demirci R "COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality." İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 13, ss.162 - 169, 2021. 10.4274/iksstd.2021.80958
ISNAD	sevinc, can vd. "COVID-19 in Hemodialysis Patients: Clinical Features, Results, and Factors Associated with Mortality". İstanbul Kanuni Sultan Süleyman Tıp Dergisi 13/3 (2021), 162-169. https://doi.org/10.4274/iksstd.2021.80958