Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives

Tuğçe GÜR MAZ, (Gazi Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)
Nursenem KARACA, (Sağlık Bilimleri Enstitüsü, Anadolu Üniversitesi, Farmakognozi Anabilim Dalı, Eskişehir, Türkiye)
Serkan LEVENT, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Eskişehir, Türkiye)
Burcu ÇALIŞKAN, (Gazi Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)
Fatih DEMİRCİ, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Eskişehir, Türkiye)
Erden BANOĞLU (Gazi Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Ankara, Türkiye)
Journal of research in pharmacy (online)
10 0
Yıl: 2021 Cilt: 25 Sayı: 5 Sayfa Aralığı: 531 - 539 Metin Dili: İngilizce DOI: 10.29228/jrp.43 İndeks Tarihi: 10-02-2022

Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives

Öz:
Pyrazoles and sulfonamides are ubiquitously classified as structural fragments in antimicrobial and antimycobacterial agents. In this present study, a series of 14 pyrazole based sulfonamide derivatives (7-20) were designed, synthesized regioisomeric structures were elucidated by spectroscopic methods. All target compounds were evaluated for their in vitro antibacterial potential against selected Gram (+) and Gram (-) bacterial strains as well as for their antimycobacterial activity. The bioactivity results demonstrated that all compounds showed selective antibacterial activity against B. subtilis with MIC values of 1-125 µg/mL. Especially, 1-[(2,4-dichlorophenyl)methyl]-N-(4- methoxybenzenesulfonyl)-3-methyl-1H-pyrazole-5-carboxamide (9), 1-[(2,4-Dichlorophenyl)methyl]-N-(4- fluorobenzenesulfonyl)-3-methyl-1H-pyrazole-5-carboxamide (10), N-(3,5-Dichlorobenzenesulfonyl)-1-[(2,4- dichlorophenyl)methyl]-3-methyl-1H-pyrazole-5-carboxamide (11) and 1-[(2,4-dichlorophenyl)methyl]-N-(4- fluorobenzenesulfonyl)-5-methyl-1H-pyrazole-3-carboxamide (17) displayed the highest antibacterial activity against B. subtilis with MIC values of 1 µg/mL, which were more effective compared to the reference chloramphenicol. As a conclusion, the snythesized new pyrazole sulfonamides stand out as promising antimicrobial agents for further development.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Gur Maz Z, karaca n, Levent S, Caliskan B, Demirci F, Banoglu E (2021). Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. , 531 - 539. 10.29228/jrp.43
Chicago Gur Maz Zehra Tugce,karaca nursenem,Levent Serkan,Caliskan Burcu,Demirci Fatih,Banoglu Erden Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. (2021): 531 - 539. 10.29228/jrp.43
MLA Gur Maz Zehra Tugce,karaca nursenem,Levent Serkan,Caliskan Burcu,Demirci Fatih,Banoglu Erden Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. , 2021, ss.531 - 539. 10.29228/jrp.43
AMA Gur Maz Z,karaca n,Levent S,Caliskan B,Demirci F,Banoglu E Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. . 2021; 531 - 539. 10.29228/jrp.43
Vancouver Gur Maz Z,karaca n,Levent S,Caliskan B,Demirci F,Banoglu E Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. . 2021; 531 - 539. 10.29228/jrp.43
IEEE Gur Maz Z,karaca n,Levent S,Caliskan B,Demirci F,Banoglu E "Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives." , ss.531 - 539, 2021. 10.29228/jrp.43
ISNAD Gur Maz, Zehra Tugce vd. "Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives". (2021), 531-539. https://doi.org/10.29228/jrp.43
APA Gur Maz Z, karaca n, Levent S, Caliskan B, Demirci F, Banoglu E (2021). Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. Journal of research in pharmacy (online), 25(5), 531 - 539. 10.29228/jrp.43
Chicago Gur Maz Zehra Tugce,karaca nursenem,Levent Serkan,Caliskan Burcu,Demirci Fatih,Banoglu Erden Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. Journal of research in pharmacy (online) 25, no.5 (2021): 531 - 539. 10.29228/jrp.43
MLA Gur Maz Zehra Tugce,karaca nursenem,Levent Serkan,Caliskan Burcu,Demirci Fatih,Banoglu Erden Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. Journal of research in pharmacy (online), vol.25, no.5, 2021, ss.531 - 539. 10.29228/jrp.43
AMA Gur Maz Z,karaca n,Levent S,Caliskan B,Demirci F,Banoglu E Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. Journal of research in pharmacy (online). 2021; 25(5): 531 - 539. 10.29228/jrp.43
Vancouver Gur Maz Z,karaca n,Levent S,Caliskan B,Demirci F,Banoglu E Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives. Journal of research in pharmacy (online). 2021; 25(5): 531 - 539. 10.29228/jrp.43
IEEE Gur Maz Z,karaca n,Levent S,Caliskan B,Demirci F,Banoglu E "Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives." Journal of research in pharmacy (online), 25, ss.531 - 539, 2021. 10.29228/jrp.43
ISNAD Gur Maz, Zehra Tugce vd. "Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives". Journal of research in pharmacy (online) 25/5 (2021), 531-539. https://doi.org/10.29228/jrp.43
Sayfa Oluşturulma Tarihi
23-04-2024 21:28

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