TY  - JOUR
TI  - Synthesis and evaluation of antibacterial and antimycobacterial activities of some new pyrazole derivatives
AB  - Pyrazoles and sulfonamides are ubiquitously classified as structural fragments in antimicrobial and antimycobacterial agents. In this present study, a series of 14 pyrazole based sulfonamide derivatives (7-20) were designed, synthesized regioisomeric structures were elucidated by spectroscopic methods. All target compounds were evaluated for their in vitro antibacterial potential against selected Gram (+) and Gram (-) bacterial strains as well as for their antimycobacterial activity. The bioactivity results demonstrated that all compounds showed selective antibacterial activity against B. subtilis with MIC values of 1-125 µg/mL. Especially, 1-[(2,4-dichlorophenyl)methyl]-N-(4- methoxybenzenesulfonyl)-3-methyl-1H-pyrazole-5-carboxamide (9), 1-[(2,4-Dichlorophenyl)methyl]-N-(4- fluorobenzenesulfonyl)-3-methyl-1H-pyrazole-5-carboxamide (10), N-(3,5-Dichlorobenzenesulfonyl)-1-[(2,4- dichlorophenyl)methyl]-3-methyl-1H-pyrazole-5-carboxamide (11) and 1-[(2,4-dichlorophenyl)methyl]-N-(4- fluorobenzenesulfonyl)-5-methyl-1H-pyrazole-3-carboxamide (17) displayed the highest antibacterial activity against B. subtilis with MIC values of 1 µg/mL, which were more effective compared to the reference chloramphenicol. As a conclusion, the snythesized new pyrazole sulfonamides stand out as promising antimicrobial agents for further development.
AU  - Levent, Serkan
AU  - Banoglu, Erden
AU  - Gur Maz, Zehra Tugce
AU  - Caliskan, Burcu
AU  - karaca, nursenem
AU  - Demirci, Fatih
DO  - 10.29228/jrp.43
PY  - 2021
JO  - Journal of research in pharmacy (online)
VL  - 25
IS  - 5
SN  - 2630-6344
SP  - 531
EP  - 539
DB  - TRDizin
UR  - http://search/yayin/detay/489226
ER  -