Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.

RENDA, GULIN; Šoral, Michal; Sohretoglu, Didem

doi:10.29228/jrp.47

Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.

Gülin RENDA, (Karadeniz Teknik Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Trabzon, Türkiye)

Michal ORAL, (Slovak Academy of Sciences, Institute of Chemistry, Analytical Department, Slovak Republic)

Didem ŞÖHRETOĞLU (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Ankara, Türkiye)

Journal of research in pharmacy (online)

2 0

Yıl: 2021 Cilt: 25 Sayı: 5 Sayfa Aralığı: 564 - 568 Metin Dili: İngilizce DOI: 10.29228/jrp.47 İndeks Tarihi: 10-02-2022

Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.

Öz:

Malva species are used for the treatment of cough, digestive problems, asthma, urticaria. Malva nicaeensis is a medicinal food plant like the other Malva species. To the best of our knowledge, no phytochemical studies on Malva nicaeensis have been reported up till now. In the present study, we aimed to assess the antioxidant effect of different extracts of M. nicaeensis, and to isolate the major metabolites of M. nicaeensis. DPPH radical scavenging effect of crude methanol extract, chloroform, ethyl acetate subextracts as well as remaining water extract prepared from the aerial parts of M. nicaeensis were tested. Phytochemical studies on the water and ethyl acetate subextract led to the isolation of a megastigman glycoside; roseoside and indole-3-carboxylic acid. The structures of the isolated compounds were identified on the basis of 1D- and 2D-NMR experiments. Biological activity test results support the ethnobotanical data of the plant.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

[1] Cullen J. Malva L. In: Davis PH (editor). Flora of Turkey and the East Aegean Islands. Vol 2, Edinburg University Press, Edinburgh. 1967; pp. 404-408.
[2] Tuzlacı E, Eryaşar Aymaz, P. Turkish folk medicinal plants, Part IV: Gönen (Balıkesir). Fitoterapia. 2001; 72(4): 323- 343.
[3] Tuzlacı E. Şifa Niyetine, Türkiye’nin Bitkisel Halk İlaçları. Alfa Basım Yayım Dağıtım Ltd. Şti., İstanbul, Turkey. 2006.
[4] Uzun E, Sarıyar G, Adsersen A, Karakoç B, Ötük G, Oktayoglu E, Pirildar S. Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species. J Ethnopharmacol. 2004; 95: 287-296.
[5] Yeşilada E, Honda G, Sezik E, Tabata M, Fujita T, Tanaka T, Takeda Y, Takaishi Y. Traditional medicine in Turkey V. Folk medicine in the inner Taurus Mountains. J Ethnopharmacol. 1995; 46: 133-152.
[6] Rocha LG, Almeida JR, Macêdo RO, Barbosa-Filho JM. A review of natural products with antileishmanial activity. Phytomedicine. 2005; 12(6-7): 514-35.
[7] Bustanji Y, Mohammad M, Hudaib M, Tawaha K, Al-Masri IM, AlKhatib HS, Issa A, Alali FQ. Screening of some medicinal plants for their pancreatic lipase ınhibitory potential. Jordan J Pharm Sci. 2011; 4(2): 81-88.
[8] Matławska I, Sikorska M. Flavonoids from flowers of Malva crispa L. (Malvaceae). Acta Pol Pharm. 2004; 61(1):65-68.
[9] Mustafa A, Ali M. New steroidal lactones and homomonoterpenic glucoside from fruits Of Malva sylvestris L. Acta Pol Pharm. 2011; 68(3): 393-401.
[10] Cutillo F, D’Abrosca B, Dellagreca M, Fiorentino A, Zarrelli A. Terpenoids and phenol derivatives from Malva silvestris. Phytochemistry. 2006; 67(5): 481-485.
[11] Veshkurova O, Golubenko Z, Pshenichnov E, Arzanova I, Uzbekov V, Sultanova E, Salikhov S, Williams HJ, Reibenspies JH, Puckhaber LS, Stipanovic RD. Malvone A, a phytoalexin found in Malva sylvestris (family Malvaceae). Phytochemistry. 2006; 67(21): 2376-2379.
[12] Halliwell B, Gutteridge MC. The antioxidants of human extracellular fluids. Arch Biochem Biophys. 1990; 280(1): 1- 8.
[13] Hollman PCH, Geelen A, Kromhout D. Dietary flavonol intake may lower stroke risk in men and women. J Nutr. 2010; 140(3): 600–604.
[14] Hollman PCH, Katan MB. Dietary flavonoids: intake, health effects and bioavailability. Food Chem Tox. 1999; 37: 937–942.
[15] Bhatt ID, Rawat S, Ranbeer S, Rawal RS. Antioxidants in medicinal plants. In: Chandra S, Lata H, Varma A. (editors). Biotechnology for Medicinal Plants. Springer-Verlag, Berlin. 2013, pp. 295-326.
[16] Alfa HH, Arroo RRJ. Over 3 decades of research on dietary flavonoid antioxidants and cancer prevention: What have we achieved? Phytochem Rev. (2019); 18: 989–1004.
[17] Bouriche H, Meziti H, Senator A. In vivo anti-inflammatory and antioxidant effects of Malva parviflora leaf extracts. Acta Hortic. 2010; 854: 23-30.
[18] Barros L, Carvalho AM, Ferreira ICFR. Leaves, flowers, immature fruits and leafy flowered stems of Malva sylvestris: a comparative study of the nutraceutical potential and composition. Food Chem Toxicol. 2010; 48(6): 1466-1472.
[19] Tawaha K, Alali FQ, Gharaibeh M, Mohammad M, El-Elimat T. Antioxidant activity and total phenolic content of selected Jordanian plant species. Food Chem. 2007; 104: 1372-1378.
[20] Yamano Y, Ito M. Synthesis of optically active vomifoliol and roseoside stereoisomers. Chem Pharm Bull. 2005; 53(5): 541-546.
[21] Wang Y-S, Liao Z, Li Y, Huang R, Zhan H-B, Yang J-H. A New Megastigmane diglycoside from Litsea glutinosa (Lour.) C. B. Rob. J Braz Chem Soc. 2011; 22 (11): 2234-2238.
[22] Burton G, Ghini AA, Gros EG. 13C NMR spectra of substituted indoles. Magn Reson Chem. 1986; 9: 829-831.
[23] Quyen VT, Nam VV, Hieu TV, Vinh LC, Huong DTM, Minh LTH, Murphy B, Minh CV, Cuong PV. Secondary metabolites from marine bacterium Streptomyces sp. G039. Vietnam J Chem. 2015; 53(2e) 142-145.
[24] Su C, Qi B, Wang J, Ding N, Wu Y, Shi X-P, Zhu Z-X, Liu X, W X-H, Zheng J, Tu P-F, Shi S-P. Megastigmane glycosides from Urena lobata. Fitoterapia. 2018; 127: 123-128.
[25] Mamadalieva NZ, Sharopov F, Giraultc J-P, Wink M, Lafont R. Phytochemical analysis and bioactivity of the aerial parts of Abutilon theophrasti (Malvaceae), a medicinal weed. Nat Prod Rep. 2014; 28(20): 1777-1779.

APA	RENDA G, Šoral M, Sohretoglu D (2021). Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. , 564 - 568. 10.29228/jrp.47
Chicago	RENDA GULIN,Šoral Michal,Sohretoglu Didem Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. (2021): 564 - 568. 10.29228/jrp.47
MLA	RENDA GULIN,Šoral Michal,Sohretoglu Didem Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. , 2021, ss.564 - 568. 10.29228/jrp.47
AMA	RENDA G,Šoral M,Sohretoglu D Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. . 2021; 564 - 568. 10.29228/jrp.47
Vancouver	RENDA G,Šoral M,Sohretoglu D Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. . 2021; 564 - 568. 10.29228/jrp.47
IEEE	RENDA G,Šoral M,Sohretoglu D "Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.." , ss.564 - 568, 2021. 10.29228/jrp.47
ISNAD	RENDA, GULIN vd. "Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.". (2021), 564-568. https://doi.org/10.29228/jrp.47

APA	RENDA G, Šoral M, Sohretoglu D (2021). Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. Journal of research in pharmacy (online), 25(5), 564 - 568. 10.29228/jrp.47
Chicago	RENDA GULIN,Šoral Michal,Sohretoglu Didem Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. Journal of research in pharmacy (online) 25, no.5 (2021): 564 - 568. 10.29228/jrp.47
MLA	RENDA GULIN,Šoral Michal,Sohretoglu Didem Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. Journal of research in pharmacy (online), vol.25, no.5, 2021, ss.564 - 568. 10.29228/jrp.47
AMA	RENDA G,Šoral M,Sohretoglu D Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. Journal of research in pharmacy (online). 2021; 25(5): 564 - 568. 10.29228/jrp.47
Vancouver	RENDA G,Šoral M,Sohretoglu D Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.. Journal of research in pharmacy (online). 2021; 25(5): 564 - 568. 10.29228/jrp.47
IEEE	RENDA G,Šoral M,Sohretoglu D "Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.." Journal of research in pharmacy (online), 25, ss.564 - 568, 2021. 10.29228/jrp.47
ISNAD	RENDA, GULIN vd. "Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All.". Journal of research in pharmacy (online) 25/5 (2021), 564-568. https://doi.org/10.29228/jrp.47