Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation

Büşra ERTAŞ, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Fadime TOPAL, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Rezzan GÜLHAN, (Marmara Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Refiye YANARDAG, (İstanbul Üniversitesi-Cerrahpaşa, Mühendislik Fakültesi, Kimya Bölümü, İstanbul, Türkiye)
Özlem SAÇAN, (İstanbul Üniversitesi-Cerrahpaşa, Mühendislik Fakültesi, Kimya Bölümü, İstanbul, Türkiye)
Göksel ŞENER (Fenerbahçe Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, İstanbul, Türkiye)
Journal of research in pharmacy (online)
3 0
Yıl: 2021 Cilt: 25 Sayı: 5 Sayfa Aralığı: 589 - 599 Metin Dili: İngilizce DOI: 10.29228/jrp.50 İndeks Tarihi: 11-02-2022

Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation

Öz:
Alzheimer's disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla (BV) has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anticholinesterase and antiinflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular (ICV) administration of streptozotocin (STZ). STZ was administered bilaterally at a dose of 3 mg/kg via ICV to rats, and BV treatment at a dose of 2 g/kg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF- and IL-1 levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.
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APA ERTAS B, Topal F, GULHAN AKER R, YANARDAG R, SAÇAN O, Şener G (2021). Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. , 589 - 599. 10.29228/jrp.50
Chicago ERTAS BÜSRA,Topal Fadime,GULHAN AKER REZZAN,YANARDAG REFIYE,SAÇAN OZLEM,Şener Göksel Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. (2021): 589 - 599. 10.29228/jrp.50
MLA ERTAS BÜSRA,Topal Fadime,GULHAN AKER REZZAN,YANARDAG REFIYE,SAÇAN OZLEM,Şener Göksel Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. , 2021, ss.589 - 599. 10.29228/jrp.50
AMA ERTAS B,Topal F,GULHAN AKER R,YANARDAG R,SAÇAN O,Şener G Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. . 2021; 589 - 599. 10.29228/jrp.50
Vancouver ERTAS B,Topal F,GULHAN AKER R,YANARDAG R,SAÇAN O,Şener G Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. . 2021; 589 - 599. 10.29228/jrp.50
IEEE ERTAS B,Topal F,GULHAN AKER R,YANARDAG R,SAÇAN O,Şener G "Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation." , ss.589 - 599, 2021. 10.29228/jrp.50
ISNAD ERTAS, BÜSRA vd. "Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation". (2021), 589-599. https://doi.org/10.29228/jrp.50
APA ERTAS B, Topal F, GULHAN AKER R, YANARDAG R, SAÇAN O, Şener G (2021). Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. Journal of research in pharmacy (online), 25(5), 589 - 599. 10.29228/jrp.50
Chicago ERTAS BÜSRA,Topal Fadime,GULHAN AKER REZZAN,YANARDAG REFIYE,SAÇAN OZLEM,Şener Göksel Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. Journal of research in pharmacy (online) 25, no.5 (2021): 589 - 599. 10.29228/jrp.50
MLA ERTAS BÜSRA,Topal Fadime,GULHAN AKER REZZAN,YANARDAG REFIYE,SAÇAN OZLEM,Şener Göksel Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. Journal of research in pharmacy (online), vol.25, no.5, 2021, ss.589 - 599. 10.29228/jrp.50
AMA ERTAS B,Topal F,GULHAN AKER R,YANARDAG R,SAÇAN O,Şener G Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. Journal of research in pharmacy (online). 2021; 25(5): 589 - 599. 10.29228/jrp.50
Vancouver ERTAS B,Topal F,GULHAN AKER R,YANARDAG R,SAÇAN O,Şener G Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation. Journal of research in pharmacy (online). 2021; 25(5): 589 - 599. 10.29228/jrp.50
IEEE ERTAS B,Topal F,GULHAN AKER R,YANARDAG R,SAÇAN O,Şener G "Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation." Journal of research in pharmacy (online), 25, ss.589 - 599, 2021. 10.29228/jrp.50
ISNAD ERTAS, BÜSRA vd. "Beta vulgaris L. var. cicla improves memory deficits in intracerebroventricular streptozotocin injected rats: Role on neuroinflammation". Journal of research in pharmacy (online) 25/5 (2021), 589-599. https://doi.org/10.29228/jrp.50
Sayfa Oluşturulma Tarihi
23-04-2024 21:29

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