The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization

ÖZAKAR, Emrah Özakar; ÖZAKAR, Rukiye Sevinç Özakar

doi:10.29228/jrp.57

The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization

Rukiye SEVİNÇ ÖZAKAR, (Atatürk Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Anabilim Dalı, Erzurum, Türkiye)

Emrah ÖZAKAR (Atatürk Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Anabilim Dalı, Erzurum, Türkiye)

Journal of research in pharmacy (online)

3 0

Yıl: 2021 Cilt: 25 Sayı: 5 Sayfa Aralığı: 653 - 666 Metin Dili: İngilizce DOI: 10.29228/jrp.57 İndeks Tarihi: 11-02-2022

The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization

Öz:

Today, treating diseases requires increasing the patient's living standard rather than just applying a classical treatment protocol. In this study, it was aimed at facilitating drug intake, reduce the dose of the active substance, reduce the number of daily doses to be taken, reduce or eliminate possible side and/or toxic effects, transport the active substance to the target area and make as much bioavailability from the active substance as possible too. For this purpose, in our study, hydrogel bead formulations with ionotropic gelation technique were developed using ampicillin sodium as a model drug and sodium alginate and HPMC K100 as polymer. CaCl2 was used as a crosslinking agent. While developing a new drug delivery system formulation, size, morphology with SEM, in vitro release profiles, release kinetics, encapsulation efficiencies, drug loading capacities, yields, and swelling capacities, FT-IR and XRD analysis were evaluated in the hydrogel beads depending on the amount of the polymer and crosslinking agent. It has been made possible to extend the duration of drug action by changing the amount of polymer and crosslinker ratios in oral drug delivery of ampicillin sodium with alginate beads. Thus, it is likely to increase patient compliance as well as to reduce drug-related side and/or toxic effects with less dosing.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZAKAR R, ÖZAKAR E (2021). The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. , 653 - 666. 10.29228/jrp.57
Chicago	ÖZAKAR Rukiye Sevinç Özakar,ÖZAKAR Emrah Özakar The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. (2021): 653 - 666. 10.29228/jrp.57
MLA	ÖZAKAR Rukiye Sevinç Özakar,ÖZAKAR Emrah Özakar The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. , 2021, ss.653 - 666. 10.29228/jrp.57
AMA	ÖZAKAR R,ÖZAKAR E The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. . 2021; 653 - 666. 10.29228/jrp.57
Vancouver	ÖZAKAR R,ÖZAKAR E The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. . 2021; 653 - 666. 10.29228/jrp.57
IEEE	ÖZAKAR R,ÖZAKAR E "The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization." , ss.653 - 666, 2021. 10.29228/jrp.57
ISNAD	ÖZAKAR, Rukiye Sevinç Özakar - ÖZAKAR, Emrah Özakar. "The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization". (2021), 653-666. https://doi.org/10.29228/jrp.57

APA	ÖZAKAR R, ÖZAKAR E (2021). The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. Journal of research in pharmacy (online), 25(5), 653 - 666. 10.29228/jrp.57
Chicago	ÖZAKAR Rukiye Sevinç Özakar,ÖZAKAR Emrah Özakar The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. Journal of research in pharmacy (online) 25, no.5 (2021): 653 - 666. 10.29228/jrp.57
MLA	ÖZAKAR Rukiye Sevinç Özakar,ÖZAKAR Emrah Özakar The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. Journal of research in pharmacy (online), vol.25, no.5, 2021, ss.653 - 666. 10.29228/jrp.57
AMA	ÖZAKAR R,ÖZAKAR E The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. Journal of research in pharmacy (online). 2021; 25(5): 653 - 666. 10.29228/jrp.57
Vancouver	ÖZAKAR R,ÖZAKAR E The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization. Journal of research in pharmacy (online). 2021; 25(5): 653 - 666. 10.29228/jrp.57
IEEE	ÖZAKAR R,ÖZAKAR E "The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization." Journal of research in pharmacy (online), 25, ss.653 - 666, 2021. 10.29228/jrp.57
ISNAD	ÖZAKAR, Rukiye Sevinç Özakar - ÖZAKAR, Emrah Özakar. "The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization". Journal of research in pharmacy (online) 25/5 (2021), 653-666. https://doi.org/10.29228/jrp.57