Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme

ERKEKOGLU, PİNAR; Adalı, Asunur; Erdemli Kose, Selinay Basak; Yirün, Anıl

doi:10.5336/pharmsci.2021-83291

Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme

Asunur ADALI, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Selinay KÖSE, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Anıl YİRÜN, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Pınar ERKEKOĞLU (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Literatür Eczacılık Bilimleri Dergisi

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Yıl: 2021 Cilt: 10 Sayı: 3 Sayfa Aralığı: 343 - 357 Metin Dili: Türkçe DOI: 10.5336/pharmsci.2021-83291 İndeks Tarihi: 17-02-2022

Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme

Öz:

Parkinson hastalığı (PH), popülasyonun önemli bir kısmını etkileyen, ilerleyici özellikte, nörodejeneratif bir hastalıktır. Çok faktörlü oluşum mekanizmaları tam olarak aydınlatılamadığı için patogenezi üzerinde birçok çalışma yürütülmektedir. PH gelişiminde en önemli risk faktörünün yaş olduğu ve hastalığın insidansının yaş ile arttığı bilinmektedir. Pestisitler, herbisitler ve ağır metaller gibi çevresel kirleticilere maruziyet de PH ile ilişkilendirilmiştir. Hastalığın patogenezinde rol oynayan genler arasında Parkin (PARK2), PTEN ile indüklenen kinaz (PINK1; PARK6), PH proteini 7 (DJ-1, PARK7), α-sinüklein (PARK1/4) ve lösince zengin tekrarlı kinaz 2 (LRRK2, PARK8) sayılabilir. Endoplazmik retikulum (ER) stresi; PH, Alzheimer hastalığı, Huntington hastalığı, amyotrofik lateral skleroz ve obezite gibi birçok hastalıkla ilişkilidir ve son yıllarda üzerinde en çok çalışılan konulardan biri olmuştur. PH’de nöronal ölüm, oksidatif stres ve mitokondriyal disfonksiyonla ER stresinin, nörodejenerasyona yol açtığı gözlemlenmiştir. Çalışmalara göre oluşan ER stresinin düzeyi çok önemlidir, PH patogenezinde doğrudan hastalık oluşturma potansiyeline sahip olmamakla beraber nörodejenerasyona ortam hazırladığı ve ilerlemesini sağladığı görülmüştür. ER stresinin, in vitro/in vivo şartlarda PH modelleri üzerinde aydınlatılması ve ER stresi mekanizmalarının incelenmesinin, hastalığın tedavisinde etkili yeni nöroprotektif ajanların geliştirilmesinde büyük önemi olacaktır. Bu derlemede; PH, ER stresi, ER stres yolağında görev alan proteinler, katlanmamış protein yanıtı ve ER stresi ile PH arasındaki ilişkinin incelenmesi amaçlanmıştır.

Anahtar Kelime:

Parkinson’s Disease, Genetic Factors and Endoplasmic Reticulum Stress: Systemic Review

Öz:

Parkinson's disease (PD) is a progressive neurodegenerative disease affecting a significant population. Since multi-factor formation mechanisms are not fully elucidated, many studies are being conducted on its pathogenesis. It is known that age is the most important risk factor in the development of PD and its incidence increases with age. Exposure to environmental pollutants such as pesticides, herbicides and heavy metals were also associated with PD. Among the genes involved in the pathogenesis, Parkin (PARK2), PTEN-induced kinase (PINK1; PARK6), PD protein 7 (DJ-1, PARK7), α-synuclein (PARK1/4) and leucine-rich repeat kinase 2 (LRRK2, PARK8) take place. Endoplasmic reticulum (ER) stress, a highly investigated subject in the last years, is associated with many diseases such as PD, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and obesity. It has been observed that neuronal death, oxidative stress, mitochondrial dysfunction and ER stress lead to neurodegeneration in PD. According to these studies, the level of ER stress is very important. Although it does not have potential to have a direct effect on the pathogenesis of PD, it has been observed that it prepares the environment for neurodegeneration and ensures its progression. The elucidation of ER stress on PD models and investigation of ER stress mechanisms will be of great importance in the development of new effective neuroprotective agents in treatment. In this review, we aimed to investigate and give information about PD, ER stress, proteins involved in the ER stress pathway, unfolded protein response (UPR) and the relationship between ER stress and PD.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Adalı A, Erdemli Kose S, Yirün A, ERKEKOGLU P (2021). Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. , 343 - 357. 10.5336/pharmsci.2021-83291
Chicago	Adalı Asunur,Erdemli Kose Selinay Basak,Yirün Anıl,ERKEKOGLU PİNAR Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. (2021): 343 - 357. 10.5336/pharmsci.2021-83291
MLA	Adalı Asunur,Erdemli Kose Selinay Basak,Yirün Anıl,ERKEKOGLU PİNAR Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. , 2021, ss.343 - 357. 10.5336/pharmsci.2021-83291
AMA	Adalı A,Erdemli Kose S,Yirün A,ERKEKOGLU P Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. . 2021; 343 - 357. 10.5336/pharmsci.2021-83291
Vancouver	Adalı A,Erdemli Kose S,Yirün A,ERKEKOGLU P Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. . 2021; 343 - 357. 10.5336/pharmsci.2021-83291
IEEE	Adalı A,Erdemli Kose S,Yirün A,ERKEKOGLU P "Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme." , ss.343 - 357, 2021. 10.5336/pharmsci.2021-83291
ISNAD	Adalı, Asunur vd. "Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme". (2021), 343-357. https://doi.org/10.5336/pharmsci.2021-83291

APA	Adalı A, Erdemli Kose S, Yirün A, ERKEKOGLU P (2021). Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi, 10(3), 343 - 357. 10.5336/pharmsci.2021-83291
Chicago	Adalı Asunur,Erdemli Kose Selinay Basak,Yirün Anıl,ERKEKOGLU PİNAR Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi 10, no.3 (2021): 343 - 357. 10.5336/pharmsci.2021-83291
MLA	Adalı Asunur,Erdemli Kose Selinay Basak,Yirün Anıl,ERKEKOGLU PİNAR Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi, vol.10, no.3, 2021, ss.343 - 357. 10.5336/pharmsci.2021-83291
AMA	Adalı A,Erdemli Kose S,Yirün A,ERKEKOGLU P Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi. 2021; 10(3): 343 - 357. 10.5336/pharmsci.2021-83291
Vancouver	Adalı A,Erdemli Kose S,Yirün A,ERKEKOGLU P Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi. 2021; 10(3): 343 - 357. 10.5336/pharmsci.2021-83291
IEEE	Adalı A,Erdemli Kose S,Yirün A,ERKEKOGLU P "Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme." Literatür Eczacılık Bilimleri Dergisi, 10, ss.343 - 357, 2021. 10.5336/pharmsci.2021-83291
ISNAD	Adalı, Asunur vd. "Parkinson Hastalığı, Genetik Faktörler ve Endoplazmik Retikulum Stresi: Sistematik Derleme". Literatür Eczacılık Bilimleri Dergisi 10/3 (2021), 343-357. https://doi.org/10.5336/pharmsci.2021-83291