Yıl: 2021 Cilt: 6 Sayı: 1 Sayfa Aralığı: 128 - 138 Metin Dili: Türkçe DOI: 10.5336/healthsci.2020-74727 İndeks Tarihi: 17-02-2022

Düşük FODMAP Diyetine Güncel Yaklaşımlar

Öz:
FODMAP fermente edilebilir oligosakkaritler, disakkaritler, monosakkaritler ve poliollerin baş harflerinden oluşan bir terimdir. FODMAP grubunda oligosakkaritlerden fruktan ve galaktanlar, disakkaritlerden laktoz, monosakkaritlerden fruktoz, poliollerden ise sorbitol ve mannitol ele alınmaktadır. FODMAP bileşenleri, ince bağırsakta zayıf emilen, kolona ulaşabilen, kolonda bakteriler tarafından hızlı fermente edilebilen, küçük ve dolayısıyla ozmotik olarak aktif moleküllerdir. Diyetle FODMAP alımı, kolonik gaz oluşturabilmekte, fermantasyon ile birlikte ozmotik yükü arttırabilmekte, bağırsak motilitesini etkileyebilmekte ve immün aktivasyon mekanizmaları ile gastrointestinal semptomların ortaya çıkmasına yol açabilmektedir. Bu karbonhidratların özellikle irritabl bağırsak sendromunun (İBS) ve bazı gastrointestinal hastalıkların semptomlarını arttırabildiği düşünülmektedir. Düşük FODMAP diyeti ise fonksiyonel gastrointestinal semptomları azaltmaya yönelik bir diyet olup, ön aşama, kısıtlayıcı aşama ve FODMAP ile yeniden tanıştırma aşamalarından oluşmaktadır. Düşük FODMAP diyetinin İBS semptomlarını azaltabileceği gösterilmiş; Crohn hastalığı, ülseratif kolit, çölyak tanısı olmayan gluten duyarlılığı, divertikülit, fonksiyonel dispepsi, kolik ve çocukluktaki abdominal ağrı semptomları üzerinde yararlı etkiler oluşturabileceğine dair kanıtlar bulunmuştur. Buna karşın, düşük FODMAP diyetinin uzun süre uygulamalarının bağırsak mikrobiyotası üzerinde oluşturacağı olumsuz etkiler ve yetersiz posa alımının neden olacağı riskler iyi değerlendirilmelidir. Bu derlemenin amacı, FODMAP grubunda yer alan karbonhidratların gastrointestinal semptomlarla ilişkisinin incelenmesi ve düşük FODMAP diyet önerilerinin oluşturulmasıdır.
Anahtar Kelime:

Current Approaches to Low FODMAP Diet

Öz:
FODMAP is a term consisting of the initials of fermentable oligosaccharides, disaccharides, monosaccharides and polyols. In the FODMAP group, fructane and galactans from oligosaccharides, lactose from disaccharides, fructose from monosaccharides, sorbitol and mannitol from polyols are discussed. FODMAP components are small, and therefore osmotically active, molecules that are poorly absorbed in the small intestine, which can reach the colon, can be quickly fermented by bacteria in the colon. Dietary FODMAP intake can produce colonic gas, increase osmotic load with fermentation, affect bowel motility, and cause immune activation mechanisms and gastrointestinal symptoms. These carbohydrates are thought to increase the symptoms of irritable bowel syndrome (IBS) and some gastrointestinal diseases. The low FODMAP diet is aimed at reducing functional gastrointestinal symptoms, consisting of the pre-stage, restrictive stage, and re-introduction to FODMAP. A low FODMAP diet has been shown to reduce IBS symptoms; evidence has been found to have beneficial effects on Crohn's disease, ulcerative colitis, gluten sensitivity without celiac diagnosis, diverticulitis, functional dispepsy, colic and abdominal pain in childhood. However, the adverse effects of longterm administration of low FODMAP diet on the intestinal microbiota and the risks of insufficient fiber intake should be well evaluated. The aim of this review is to investigate the relationship between carbohydrates in the FODMAP group and gastrointestinal symptoms and to establish low FODMAP dietary recommendations.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1. Tokay a. Karbonhidratlar: sindirim ve Emilimi. Özenoğlu a, editör. Beslenmenin Esasları ve sağlığın Korunmasında Beslenme. 1. Baskı. ankara: Hatiboğlu Yayınevi; 2016. p. 335-408.
  • 2. Nantel g. Carbohydrates in human nutrition. Food Nutrition and agriculture. 1999:6-10. [Link]
  • 3. gibson PR, shepherd sJ. Evidence-based dietary management of functional gastrointestinal symptoms: The FODMaP approach. J gastroenterol Hepatol. 2010;25(2):252-8. [Crossref] [PubMed]
  • 4. Barrett Js, gibson PR. Development and validation of a comprehensive semi-quantitative food frequency questionnaire that includes FODMaP intake and glycemic index. J am Diet assoc. 2010;110(10):1469-76.[Crossref] [PubMed]
  • 5. aksoy M. Beslenme Biyokimyası. 1. Baskı. ankara: Hatiboğlu Yayınları; 2011.
  • 6. Biesiekierski JR, Rosella O, Rose R, Liels K, Barrett Js, shepherd sJ, et al. Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals. J Hum Nutr Diet. 2011;24(2):154- 76.[Crossref] [PubMed]
  • 7. staudacher HM, Irving PM, Lomer MC, Whelan K. Mechanisms and efficacy of dietary FODMaP restriction in IBs. Nat Rev gastroenterol Hepatol. 2014;11(4):256-66.[Crossref] [PubMed]
  • 8. Nanda R, shu LH, Thomas JR. a FODMaP Diet Update: Craze or Credible? Pract gastroenterol. 2012;112:37.[Link]
  • 9. Tuck CJ, Muir Jg, Barrett Js, gibson PR. Fermentable oligosaccharides, disaccharides, monosaccharides and polyols: role in irritable bowel syndrome. Expert Rev gastroenterol Hepatol. 2014;8(7):819-34. [Crossref] [PubMed]
  • 10. Dugum M, Barco K, garg s. Managing irritable bowel syndrome: The low-FODMaP diet. Cleve Clin J Med. 2016;83(9):655-62.[Crossref] [PubMed]
  • 11. Khan Ma, Nusrat s, Khan MI, Nawras a, Bielefeldt K. Low-FODMaP Diet for Irritable Bowel syndrome: Is It Ready for Prime Time? Dig Dis sci. 2015;60(5):1169-77.[Crossref] [PubMed]
  • 12. Muir Jg, Rose R, Rosella O, Liels K, Barrett Js, shepherd sJ, et al. Measurement of shortchain carbohydrates in common australian vegetables and fruits by high-performance liquid chromatography (HPLC). J agric Food Chem. 2009;57(2):554-65. [Crossref] [PubMed]
  • 13. Murray K, Wilkinson-smith V, Hoad C, Costigan C, Cox E, Lam C, et al. Differential effects of FODMaPs (fermentable oligo-, di-, monosaccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI. am J gastroenterol. 2014;109(1):110- 9.[Crossref] [PubMed] [PMC]
  • 14. Barrett Js. Extending our knowledge of fermentable, short-chain carbohydrates for managing gastrointestinal symptoms. Nutr Clin Pract. 2013;28(3):300-6.[Crossref] [PubMed]
  • 15. Barrett Js, gearry RB, Muir Jg, Irving PM, Rose R, Rosella O, et al. Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon. aliment Pharmacol Ther. 2010;31(8):874-82.[Crossref] [PubMed]
  • 16. Eswaran s. Low FODMaP in 2017: Lessons learned from clinical trials and mechanistic studies. Neurogastroenterol Motil. 2017;29(4). [Crossref] [PubMed]
  • 17. Hill P, Muir Jg, gibson PR. Controversies and Recent Developments of the Low-FODMaP Diet. gastroenterol Hepatol (N Y). 2017; 13(1):36-45.[PubMed] [PMC]
  • 18. McIntosh K, Reed DE, schneider T, Dang F, Keshteli aH, De Palma g, et al. FODMaPs alter symptoms and the metabolome of patients with IBs: a randomised controlled trial. gut. 2017;66(7):1241-51. Erratum in: gut. 2019;68(7):1342.[Crossref] [PubMed]
  • 19. Kortlever T, Hebblethwaite C, Leeper J, O'Brien L, Mulder C, gearry RB, et al. Low FODMaP diet efficacy in IBs patients-what is the evidence and what else do we need to know? N z Med J. 2016;129(1442):75-83. [PubMed]
  • 20. Barrett Js, gIbson PR. Clinical ramifications of malabsorption of fructose and other shortchain carbohydrates. Pract gastroenterol. 2007;31(8):51-65.[Link]
  • 21. University M. Monash University Low FODMaP Diet guide. [Link]
  • 22. Barrett Js. How to institute the low-FODMaP diet. J gastroenterol Hepatol. 2017;32 suppl 1:8-10.[Crossref] [PubMed]
  • 23. Tuck C, Barrett J. Re-challenging FODMaPs: the low FODMaP diet phase two. J gastroenterol Hepatol. 2017;32 suppl 1:11-5.[Crossref] [PubMed]
  • 24. Halmos EP, Power Va, shepherd sJ, gibson PR, Muir Jg. a diet low in FODMaPs reduces symptoms of irritable bowel syndrome. gastroenterology. 2014;146(1):67-75.e5.[Crossref] [PubMed]
  • 25. Chumpitazi BP, Cope JL, Hollister EB, Tsai CM, McMeans aR, Luna Ra, et al. Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMaP diet in children with the irritable bowel syndrome. aliment Pharmacol Ther. 2015;42(4):418-27.[Crossref] [PubMed] [PMC]
  • 26. arslan N. irritabl barsak sendromunda prebiyotik ve probiyotiklerin kullanımı. Kara a, Coşkun T, editörler. Teoriden Kliniğe Prebiyotikler Probiyotikler. 1. Baskı. istanbul: akademi Yayınevi; 2014. p.257-71.
  • 27. Yao CK, Tuck CJ. The clinical value of breath hydrogen testing. J gastroenterol Hepatol. 2017;32 suppl 1:20-22. [Crossref] [PubMed]
  • 28. Mazzawi T, Hausken T, gundersen D, Elsalhy M. Dietary guidance normalizes large intestinal endocrine cell densities in patients with irritable bowel syndrome. Eur J Clin Nutr. 2016;70(2):175-81.[Crossref] [PubMed] [PMC]
  • 29. Böhn L, störsrud s, Liljebo T, Collin L, Lindfors P, Törnblom H, et al. Diet low in FODMaPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. gastroenterology. 2015;149(6):1399-1407.e2. [Crossref] [PubMed]
  • 30. Pedersen N, ankersen DV, Felding M, Wachmann H, Végh z, Molzen L, et al. LowFODMaP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease. World J gastroenterol. 2017;23(18): 3356-66. [Crossref] [PubMed] [PMC]
  • 31. gibson PR, shepherd sJ. Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMaP hypothesis. aliment Pharmacol Ther. 2005;21(12): 1399-409. [Crossref] [PubMed]
  • 32. gearry RB, Irving PM, Barrett Js, Nathan DM, shepherd sJ, gibson PR, et al. Reduction of dietary poorly absorbed short-chain carbohydrates (FODMaPs) improves abdominal symptoms in patients with inflammatory bowel disease-a pilot study. J Crohns Colitis. 2009;3(1):8-14.[Crossref] [PubMed]
  • 33. Donnellan CF, Yann LH, Lal s. Nutritional management of Crohn's disease. Therap adv gastroenterol. 2013;6(3):231-42.[Crossref] [PubMed] [PMC]
  • 34. Petrarca L, Nenna R, Mastrogiorgio g, Florio M, Brighi M, Pontone s, et al. Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy. World J Methodol. 2014;4(3): 189-96. [Crossref] [PubMed] [PMC]
  • 35. Biesiekierski JR, Peters sL, Newnham ED, Rosella O, Muir Jg, gibson PR, et al. No effects of gluten in patients with selfreported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. gastroenterology. 2013;145(2):320-8.e1-3.[Crossref] [PubMed]
  • 36. zanini B, Marullo M, Ricci C, Lanzarotto F, Lanzini a. sa1989 non celiac gluten sensitivity (NCgs) is outnumbered by FODMaPs sensitivity in patients spontaneously adhering to gluten free diet (gFD): a two stage double blind prospective study. gastroenterology. 2014;146(5):s-348.[Crossref]
  • 37. Krigel a, Lebwohl B. Nonceliac gluten sensitivity. adv Nutr. 2016;7(6):1105-10.[Crossref] [PubMed] [PMC]
  • 38. Croagh C, shepherd sJ, Berryman M, Muir Jg, gibson PR. Pilot study on the effect of reducing dietary FODMaP intake on bowel function in patients without a colon. Inflamm Bowel Dis. 2007;13(12):1522-8.[Crossref] [PubMed]
  • 39. Uno Y, van Velkinburgh JC. Logical hypothesis: Low FODMaP diet to prevent diverticulitis. World J gastrointest Pharmacol Ther. 2016;7(4):503-12.[Crossref] [PubMed] [PMC]
  • 40. Tan VP. The low-FODMaP diet in the management of functional dyspepsia in East and southeast asia. J gastroenterol Hepatol. 2017;32 suppl 1:46-52.[Crossref] [PubMed]
  • 41. Halmos EP. Role of FODMaP content in enteral nutrition-associated diarrhea. J gastroenterol Hepatol. 2013;28 suppl 4:25-8. [Crossref] [PubMed]
  • 42. Iacovou M, Mulcahy EC, Truby H, Barrett Js, gibson PR, Muir Jg, et al. Reducing the maternal dietary intake of indigestible and slowly absorbed short-chain carbohydrates is associated with improved infantile colic: a proofof-concept study. J Hum Nutr Diet. 2018;31(2):256-65.[Crossref] [PubMed]
  • 43. Iacovou M. adapting the low FODMaP diet to special populations: infants and children. J gastroenterol Hepatol. 2017;32 suppl 1:43- 5.[Crossref] [PubMed]
  • 44. Lis D, ahuja KD, stellingwerff T, Kitic CM, Fell J. Case study: Utilizing a Low FODMaP Diet to Combat Exercise-Induced gastrointestinal symptoms. Int J sport Nutr Exerc Metab. 2016;26(5):481-7.[Crossref] [PubMed]
  • 45. Bennet sMP, Böhn L, störsrud s, Liljebo T, Collin L, Lindfors P, et al. Multivariate modelling of faecal bacterial profiles of patients with IBs predicts responsiveness to a diet low in FODMaPs. gut. 2018;67(5):872-81.[Crossref] [PubMed]
  • 46. staudacher HM, Lomer MC, anderson JL, Barrett Js, Muir Jg, Irving PM, et al. Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. J Nutr. 2012;142(8):1510-8. [Crossref] [PubMed]
  • 47. Halmos EP, Christophersen CT, Bird aR, shepherd sJ, Muir Jg, gibson PR, et al. Consistent Prebiotic Effect on gut Microbiota With altered FODMaP Intake in Patients with Crohn's Disease: a Randomised, Controlled Cross-Over Trial of Well-Defined Diets. Clin Transl gastroenterol. 2016;7(4):e164.[Crossref] [PubMed] [PMC]
  • 48. staudacher HM, Lomer MCE, Farquharson FM, Louis P, Fava F, Franciosi E, et al. a Diet Low in FODMaPs Reduces symptoms in Patients With Irritable Bowel syndrome and a Probiotic Restores Bifidobacterium species: a Randomized Controlled Trial. gastroenterology. 2017;153(4):936-47.[Crossref] [PubMed]
  • 49. satherley R, Howard R, Higgs s. Disordered eating practices in gastrointestinal disorders. appetite. 2015;84:240-50.[Crossref] [PubMed]
  • 50. Catassi g, Lionetti E, gatti s, Catassi C. The Low FODMaP Diet: Many Question Marks for a Catchy acronym. Nutrients. 2017;9(3):292. [Crossref] [PubMed] [PMC]
APA TÜRK O, BUYUKTUNCER Z (2021). Düşük FODMAP Diyetine Güncel Yaklaşımlar. , 128 - 138. 10.5336/healthsci.2020-74727
Chicago TÜRK OYKÜ PEREN,BUYUKTUNCER ZEHRA Düşük FODMAP Diyetine Güncel Yaklaşımlar. (2021): 128 - 138. 10.5336/healthsci.2020-74727
MLA TÜRK OYKÜ PEREN,BUYUKTUNCER ZEHRA Düşük FODMAP Diyetine Güncel Yaklaşımlar. , 2021, ss.128 - 138. 10.5336/healthsci.2020-74727
AMA TÜRK O,BUYUKTUNCER Z Düşük FODMAP Diyetine Güncel Yaklaşımlar. . 2021; 128 - 138. 10.5336/healthsci.2020-74727
Vancouver TÜRK O,BUYUKTUNCER Z Düşük FODMAP Diyetine Güncel Yaklaşımlar. . 2021; 128 - 138. 10.5336/healthsci.2020-74727
IEEE TÜRK O,BUYUKTUNCER Z "Düşük FODMAP Diyetine Güncel Yaklaşımlar." , ss.128 - 138, 2021. 10.5336/healthsci.2020-74727
ISNAD TÜRK, OYKÜ PEREN - BUYUKTUNCER, ZEHRA. "Düşük FODMAP Diyetine Güncel Yaklaşımlar". (2021), 128-138. https://doi.org/10.5336/healthsci.2020-74727
APA TÜRK O, BUYUKTUNCER Z (2021). Düşük FODMAP Diyetine Güncel Yaklaşımlar. Türkiye Klinikleri Sağlık Bilimleri Dergisi, 6(1), 128 - 138. 10.5336/healthsci.2020-74727
Chicago TÜRK OYKÜ PEREN,BUYUKTUNCER ZEHRA Düşük FODMAP Diyetine Güncel Yaklaşımlar. Türkiye Klinikleri Sağlık Bilimleri Dergisi 6, no.1 (2021): 128 - 138. 10.5336/healthsci.2020-74727
MLA TÜRK OYKÜ PEREN,BUYUKTUNCER ZEHRA Düşük FODMAP Diyetine Güncel Yaklaşımlar. Türkiye Klinikleri Sağlık Bilimleri Dergisi, vol.6, no.1, 2021, ss.128 - 138. 10.5336/healthsci.2020-74727
AMA TÜRK O,BUYUKTUNCER Z Düşük FODMAP Diyetine Güncel Yaklaşımlar. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021; 6(1): 128 - 138. 10.5336/healthsci.2020-74727
Vancouver TÜRK O,BUYUKTUNCER Z Düşük FODMAP Diyetine Güncel Yaklaşımlar. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021; 6(1): 128 - 138. 10.5336/healthsci.2020-74727
IEEE TÜRK O,BUYUKTUNCER Z "Düşük FODMAP Diyetine Güncel Yaklaşımlar." Türkiye Klinikleri Sağlık Bilimleri Dergisi, 6, ss.128 - 138, 2021. 10.5336/healthsci.2020-74727
ISNAD TÜRK, OYKÜ PEREN - BUYUKTUNCER, ZEHRA. "Düşük FODMAP Diyetine Güncel Yaklaşımlar". Türkiye Klinikleri Sağlık Bilimleri Dergisi 6/1 (2021), 128-138. https://doi.org/10.5336/healthsci.2020-74727