Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism
Yıl: 2021 Cilt: 5 Sayı: 3 Sayfa Aralığı: 317 - 321 Metin Dili: İngilizce DOI: 10.14744/ejmi.2021.59602 İndeks Tarihi: 17-02-2022
Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism
Öz: Objectives: Renal function is influenced by thyroid status. Changes in routine clinical chemical indicators of renal func tion in the hypothroid status are not well characterized, and are infrequently discussed in standart internal medicinetextbooks. This study was done to determine the relationship between renal function and different degrees of thyroiddysfunction. Methods: In this cross-sectional retrospective study, thyroid and kidney function tests were analyzed in 201 patientsof whom 120 were subclinical hypothyroidism and 81 patients were overt hypothyroidism. These were compared with203 age-and sex-matched euthyroid control group. Results: Overt hypothyroid subjects showed significantly raised serum urea, creatinin and uric acid levels as comparedto controls but subclinical hypothyroid patients did not showed significant increased levels of serum urea, uric acid andcreatinin levels. Conclusion: Hypothyroid state is associated with significant derangement in biochemical parameters of renal function.Therefore, the renal function should be regularly monitored in hypothyroid patients.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
- 1. Weetman AP, McGregor AM. Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 1994;15:788–830. [CrossRef]
- 2. Derubertis FR, Michelis MF, Bloom ME, Mintz DH, Field JB, Davis BB. Impaired water excretion in myxedema. Am J Med 1971;51:41–53. [CrossRef]
- 3. Montenegro J, Gonzalez O, Saracho R, Aguirre R, Gonzalez O, Martinez I. Changes in renal function in primary hypothyroidism. Am J Kidney Dis 1996;27:195–8. [CrossRef]
- 4. Moses MA, Scheinman SJ. The kidneys and electrolyte metabolism in hypothyroidism. In: Braverman LE, Utiger Rd, editors. Werner and Ingbar's The Thyroid. 7th ed. Philadelphia, Pa: Lippincott-Raven Press; 1996 p. 812–5.
- 5. Kelepouris E, Agus ZS. Effects of endocrine disease on the kidney. In: Becker KL, editor. Endocrinology and Metabolism. 2nd ed. Philadelphia, Pa: JB Lippincott;1995. p. 1754–8.
- 6. Al-Fifi S, Girardin C, Sharma A, Rodd C. Moderate renal failure in association withprolonged acquired hypothyroidism in children. Acta Paediatr 1999;88:715–8. [CrossRef]
- 7. Del-Rio CG, Tapia CL, Picazo AB, Ruiz Moreno JA, Hortas Nieto ML, Romero GJ. Renal failure and acquired hypothyroidism. Pediatr Nephrol 2003;18:290–2. [CrossRef]
- 8. Kreisman SH, Hennessey JV. Consistent reversible elevations of serum creatinine levels in severe hypothyroidism. Arch Intern Med 1999;159:79–82. [CrossRef]
- 9. Karanikas G, Schütz M, Szabo M, Becherer A, Wiesner K, Dudczak R, et al. Isotopic renal function studies in severe hypothyroidism and after thyroid hormone replacement therapy. Am J Nephrol 2004;24:41–5. [CrossRef]
- 10. Nakahama H, Sakaguchi K, Horita Y, Sasaki O, Nakamura S, Inenaga T, et al. Treatment of severe hypothyroidism reduced serum creatinine levels in two chronic renal failure patients. Nephron 2001;88:264–7.
- 11. Feinstein EI, Kaptein EM, Nicoloff JT & Massry SG. Thyroid function in patients with nephrotic syndrome and normal renal function. American Journal of Nephrology 1982;2:70–76.
- 12. Kaptein EM, Feinstein EI & Massry SG. Thyroid hormone metabolism in renal diseases. Contributions to Nephrology 1982;33:122.
- 13. Verhelst J, Berwaerts J, Marescau B, Abs R, Neels H, Mahler C, et al. Serum creatine, creatinine, and other guanidino compounds in patients with thyroid dysfunction. Metabolism 1997;46:1063–7. [CrossRef]
- 14. Vargas F, Moreno JM, Rodríguez-Gómez I, Wangensteen R, Osuna A, Alvarez-Guerra M, et al. Vascular and renal function in experimental thyroid disorders. Eur J Endocrinol 2006;154:197–212. [CrossRef]
- 15. Nikolaeva AV & Pimenov LT. Lipid metabolism and functional status of the kidney in hypothyroid patients depending on the phase of disease. Terapevticheskii Arkhiv 2002;74:20–3.
- 16. Elgadi A, Verbovski P, Marcus C & Berg UB. Long-term effects ofprimary hypothyroidism on renal function in children. Journal of Pediatrics 2008;152:860–4. [CrossRef]
- 17. Mahjoub S, Ben Dhia N, Achour A, Zebidi A, Frih A, Elmay M. Primary hypothyroidism and glomerular involvement. Ann Endocrinol 1991;52:289–92.
- 18. Weetman AP, Pinching AJ, Pussel BA, Evans DJ, Sweny P, Rees AJ. Membranous glomerulonephritis and autoimmune thyroid disease. Clin Nephrol 1981;15:50–1.
- 19. İsmail AA, Burr WA, Walker PL. Acute changes in serum thyrotropin in treated Addison’s disease. Clin Endocrinol (Oxf ) 1989;30:225–30. [CrossRef]
- 20. Iglesias P, Díez JJ. Review-Thyroid dysfunction and kidney disease. Eur J Endocrinol 2009;160:503–1.
- 21. Saini V, Yadav A, Arora MK, Arora S, Singh R, Bhattacharjee J. Correlation of creatinine with TSH levels in overt hypothyroidism - a requirement for monitoring of renal function in hypothyroid patients? Clin Biochem 2012;45:212–4.
- 22. Dariyerli N, Andican G, Catakoğlu AB, Hatemi H, Burçak G. Hyperuricemia in hypothyroidism:is it associated with post-insulin infusion glycemic response? Tohoku J Exp Med 2003;199:59–68.
- 23. Giordano N, Santacroce C, Mattii G, Geraci S, Amendola A, Gennari C. Hyperuricemia and gout in thyroid endocrine disorders. Clin Exp Rheumatol 2001;19:661–5.
- 24. Yokogoshi Y, Saito S. Abnormal serum uric acid level in endocrine disorders. Nippon Rinsho 1996;54:3360–3.
| APA | AKAGÜNDÜZ B, AKÇAKAYA M (2021). Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. , 317 - 321. 10.14744/ejmi.2021.59602 |
| Chicago | AKAGÜNDÜZ Baran,AKÇAKAYA Mesut Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. (2021): 317 - 321. 10.14744/ejmi.2021.59602 |
| MLA | AKAGÜNDÜZ Baran,AKÇAKAYA Mesut Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. , 2021, ss.317 - 321. 10.14744/ejmi.2021.59602 |
| AMA | AKAGÜNDÜZ B,AKÇAKAYA M Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. . 2021; 317 - 321. 10.14744/ejmi.2021.59602 |
| Vancouver | AKAGÜNDÜZ B,AKÇAKAYA M Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. . 2021; 317 - 321. 10.14744/ejmi.2021.59602 |
| IEEE | AKAGÜNDÜZ B,AKÇAKAYA M "Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism." , ss.317 - 321, 2021. 10.14744/ejmi.2021.59602 |
| ISNAD | AKAGÜNDÜZ, Baran - AKÇAKAYA, Mesut. "Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism". (2021), 317-321. https://doi.org/10.14744/ejmi.2021.59602 |
| APA | AKAGÜNDÜZ B, AKÇAKAYA M (2021). Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. Eurasian Journal of Medical Investigation, 5(3), 317 - 321. 10.14744/ejmi.2021.59602 |
| Chicago | AKAGÜNDÜZ Baran,AKÇAKAYA Mesut Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. Eurasian Journal of Medical Investigation 5, no.3 (2021): 317 - 321. 10.14744/ejmi.2021.59602 |
| MLA | AKAGÜNDÜZ Baran,AKÇAKAYA Mesut Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. Eurasian Journal of Medical Investigation, vol.5, no.3, 2021, ss.317 - 321. 10.14744/ejmi.2021.59602 |
| AMA | AKAGÜNDÜZ B,AKÇAKAYA M Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. Eurasian Journal of Medical Investigation. 2021; 5(3): 317 - 321. 10.14744/ejmi.2021.59602 |
| Vancouver | AKAGÜNDÜZ B,AKÇAKAYA M Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism. Eurasian Journal of Medical Investigation. 2021; 5(3): 317 - 321. 10.14744/ejmi.2021.59602 |
| IEEE | AKAGÜNDÜZ B,AKÇAKAYA M "Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism." Eurasian Journal of Medical Investigation, 5, ss.317 - 321, 2021. 10.14744/ejmi.2021.59602 |
| ISNAD | AKAGÜNDÜZ, Baran - AKÇAKAYA, Mesut. "Evaluation of the Correlation of Urea, Creatine, and Uric AcidLevels with TSH in Patients with Newly Diagnosed Overt andSubclinic Hypothyroidism". Eurasian Journal of Medical Investigation 5/3 (2021), 317-321. https://doi.org/10.14744/ejmi.2021.59602 |
