Objective: This study aims to examine the relationship between the compassion of nurses and the affecting factors on their level of job satisfaction. Material and Methods: The population of this descriptive study consisted of 550 nurses working at a university hospital, 209 of which have met the inclusion criteria constituted the study sample. The research data was collected using the Introductory Information Form developed by the researchers in line with the literature, the Compassion Scale, and the Nurse Job Satisfaction Scale. The data was assessed and analyzed using the SPSS V23 program, descriptive statistics, the independent two-sample t-test, one-way analysis of variance (ANOVA), the TUKEY test, the Mann-Whitney U test, the Kruskal-Wallis test, and the Spearman correlation analysis. The significance level was considered 0.05 for all comparisons. Results: The level of job satisfaction among nurses who had a bachelor’s degree in nursing (F3=2.71, p=0.046), those who worked in pediatric clinics (Kruskal-Wallis (KW) 4=22.35, p<0.001) those who willingly chose the nursing profession (F204=1.91, p<0.05), and those who were satisfied with their jobs (F4=9.77, p<0.001)-as well as the level of compassion among nurses who were satisfied with their jobs (F4=5.88, p<0.001) and those who reported to empathize with patients (KW2=13.10, p<0.001)-were statistically, significantly higher than the others. A positive correlation was found between the total mean scores of nurses on the compassion and job satisfaction scales(r=0.30, p<0.001). Conclusion: The nurses satisfied with their jobs had higher levels of job satisfaction and compassion. As the nurses’ job satisfaction increased, the level of their compassion also increased.