Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış
Yıl: 2021 Cilt: 6 Sayı: 2 Sayfa Aralığı: 329 - 339 Metin Dili: Türkçe DOI: 10.5336/healthsci.2020-76200 İndeks Tarihi: 18-02-2022
Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış
Öz: Nonalkolik yağlı karaciğer hastalığı (NAYKH) çocuklarda en sık görülen karaciğer hastalığı olup basit yağ infiltrasyonundan alkolik olmayan “steatohepatite” kadar uzanan karaciğer hastalıkları spektrumu olarak tanımlanmaktadır. NAYKH, çocuklarda insülin direnci, obezite ve dislipidemi yüksek trigliserid ve düşük yüksek yoğunluklu lipoprotein kolesterol düzeyleri ile ilişkilidir. NAYKH’nin patogenezi henüz tam olarak bilinmemesine rağmen genetik ve çevresel birçok faktörün etkili olduğu gösterilmiştir. Pediatrik NAYKH’de prenatal (maternal obezite, gestasyonel diyabet, düşük doğum ağırlığı vb.) ve postnatal (obezite, hiperinsülinemi, insülin direnci vb.) birçok faktörün hastalığın patogenezinde rol oynadığı öne sürülmüştür. NAYKH, tedavi edilmediği durumlarda, siroz, hepatosellüler karsinom ve son dönem karaciğer hastalığına kadar ilerleyebilmektedir. Pediatrik NAYKH’de primer tedavi olarak yaşam tarzı değişikliği önerilmektedir. Yaşam tarzı değişikliği tedavisinde tıbbi beslenme tedavisi ve egzersiz kombinasyonu yoluyla vücut ağırlık kaybı hedeflenmektedir. Ancak NAYKH olan çocuklarda hangi tip diyetin uygulanacağına yönelik kanıta dayalı bilgi mevcut değildir. Ayrıca yapılacak fiziksel aktivitenin türü ve süresi ile ilgili net bir öneri bulunmamaktadır. Son yıllarda, çocuklarda yapılan ve planlanan çalışmalarda NAYKH üzerine etkili olabilecek diyet bileşimi, diyet modelleri, probiyotik, antioksidanlar üzerinde odaklanılmıştır. Tıbbi beslenme tedavisi açısından antiinflamatuar özellikte olan Akdeniz diyeti veya Hipertansiyonu Durdurmak İçin Beslenme Yaklaşımı (DASH) diyet modellerinin NAYKH’nin önlenmesi ve tedavisinde etkili olabileceği bildirilmiştir. Bu derlemede, NAYKH olan çocuklarda tıbbi beslenme tedavisine yönelik olarak güncel yaklaşımları değerlendirmek amaçlanmıştır.
Anahtar Kelime: Nonalcoholic Fatty Liver Disease in Children: A Current Overview of Nutrition Therapy
Öz: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in children and is defined as a spectrum of liver diseases ranging from simple fat infiltration to non-alcoholic steatohepatitis. NAFLD is associated with insulin resistance, obesity and dyslipidemia high triglyceride and low high density lipoprotein cholesterol levels in children. Although the pathogenesis of NAYKH is not yet fully known, many genetic and environmental factors have been shown to be effective. It has been suggested that prenatal (maternal obesity, gestational diabetes, low birth weight, etc.) and postnatal (obesity, hyperinsulinemia, insulin resistance, etc.) factors play a role in the pathogenesis of pediatric NAFLD. NAFLD can progress to cirrhosis, hepatocellular carcinoma, and end-stage liver disease when untreated. Lifestyle change is recommended as the primary treatment in pediatric NAFLD. In the treatment of lifestyle change, body weight loss is targeted through a combination of medical nutrition therapy and exercise. However, there is no evidence-based information on what type of diet to use in children with NAFLD. In addition, there is no clear recommendation regarding the type and duration of the physical activity. In studies conducted and planned in children in recent years, it has been focused on diet composition, diet models, probiotics, antioxidants that may be effective on NAFLD. It has been reported that Mediterranean or Dietary Approach to Stop Hypertension (DASH) diet models, which are antiinflammatory, can be effective in the prevention and treatment of NAFLD. In this review, it is aimed to evaluate current approaches to medical nutrition therapy in children with NAFLD.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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| APA | YURTDAS G, AKBULUT G (2021). Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. , 329 - 339. 10.5336/healthsci.2020-76200 |
| Chicago | YURTDAS GAMZE,AKBULUT GAMZE Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. (2021): 329 - 339. 10.5336/healthsci.2020-76200 |
| MLA | YURTDAS GAMZE,AKBULUT GAMZE Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. , 2021, ss.329 - 339. 10.5336/healthsci.2020-76200 |
| AMA | YURTDAS G,AKBULUT G Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. . 2021; 329 - 339. 10.5336/healthsci.2020-76200 |
| Vancouver | YURTDAS G,AKBULUT G Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. . 2021; 329 - 339. 10.5336/healthsci.2020-76200 |
| IEEE | YURTDAS G,AKBULUT G "Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış." , ss.329 - 339, 2021. 10.5336/healthsci.2020-76200 |
| ISNAD | YURTDAS, GAMZE - AKBULUT, GAMZE. "Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış". (2021), 329-339. https://doi.org/10.5336/healthsci.2020-76200 |
| APA | YURTDAS G, AKBULUT G (2021). Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. Türkiye Klinikleri Sağlık Bilimleri Dergisi, 6(2), 329 - 339. 10.5336/healthsci.2020-76200 |
| Chicago | YURTDAS GAMZE,AKBULUT GAMZE Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. Türkiye Klinikleri Sağlık Bilimleri Dergisi 6, no.2 (2021): 329 - 339. 10.5336/healthsci.2020-76200 |
| MLA | YURTDAS GAMZE,AKBULUT GAMZE Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. Türkiye Klinikleri Sağlık Bilimleri Dergisi, vol.6, no.2, 2021, ss.329 - 339. 10.5336/healthsci.2020-76200 |
| AMA | YURTDAS G,AKBULUT G Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021; 6(2): 329 - 339. 10.5336/healthsci.2020-76200 |
| Vancouver | YURTDAS G,AKBULUT G Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021; 6(2): 329 - 339. 10.5336/healthsci.2020-76200 |
| IEEE | YURTDAS G,AKBULUT G "Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış." Türkiye Klinikleri Sağlık Bilimleri Dergisi, 6, ss.329 - 339, 2021. 10.5336/healthsci.2020-76200 |
| ISNAD | YURTDAS, GAMZE - AKBULUT, GAMZE. "Çocuklarda Nonalkolik Yağlı Karaciğer Hastalığı: Beslenme Tedavisine Güncel Bakış". Türkiye Klinikleri Sağlık Bilimleri Dergisi 6/2 (2021), 329-339. https://doi.org/10.5336/healthsci.2020-76200 |
