The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer

Horozoğlu, Cem; arıkan, soykan; KÜÇÜKHÜSEYİN, Özlem; DEMİRKOL, ŞEYDA; Hakan, Mehmet Tolgahan; SÖNMEZ, Dilara; Yaylim, Ilhan

doi:10.1515/tjb-2020-0075

The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer

Cem HOROZOĞLU, (Biruni Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Dilara SÖNMEZ, (İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, Moleküler Tıp Anabilim Dalı, İstanbul, Türkiye)

Özlem KÜÇÜKHÜSEYİN, (İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, Moleküler Tıp Anabilim Dalı, İstanbul, Türkiye)

Şeyda DEMİRKOL, (Biruni Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, İstanbul, Türkiye)

Mehmet Tolgahan HAKAN, (İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, Moleküler Tıp Anabilim Dalı, İstanbul, Türkiye)

Soykan ARIKAN, (İstanbul Eğitim ve Araştırma Hastanesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye)

İlhan YAYLIM (İstanbul Üniversitesi, Moleküler Tıp Bölümü, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, İstanbul, Türkiye)

Türk Biyokimya Dergisi

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Yıl: 2021 Cilt: 46 Sayı: 3 Sayfa Aralığı: 273 - 279 Metin Dili: İngilizce DOI: 10.1515/tjb-2020-0075 İndeks Tarihi: 20-02-2022

The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer

Öz:

Objectives: Immunoregulatory GITR, OX40L and PD-1 molecules play an active role in the regulation of tumor microenvironment and have been shown in many can cer types. However, there are limited studies of these molecules in terms of gastric cancer. In our study, we aimed to determine the histopathological significance of sPD-1, sOX40L and sGITR levels in gastric cancer cases. Methods: Serum samples were obtained from peripheral blood samples of 20 gastric cancer and 34 healthy controls and candidate biomarker levels were determined by ELISA. Results: sGITR level was found to be 48.28 ± 2.66 pg/mL in the gastric cancers and 39.19 ± 2.01 pg/mL in the controls (p=0.014). sOX40L level was 6.13 ± 0.64 pg/mL in the pa tients and 8.68 ± 0.99 pg/mL in the control, and the sOX40L level was found to be 1.41 times higher in the control group compared to the patients (p=0.033). sGITR levels of signet-ring cell carcinoma were found to be higher than other adenocarcinomas (p=0.04). There was no dif ference between groups in sPD-1 (p=0.490). Conclusions: We suggest that sGITR, sOX40L and mole cules may play a role in tumor microenvironment regula tion and histological type in gastric cancer.

Anahtar Kelime:

sPD-1, sOX40L ve sGITR’nin gastrik kanserde klinikopatolojik ve histopatolojik açıdan önemi

Öz:

Giriş: İmmünoregülatör GITR, OX40L ve PD-1 molekülleri, tümör mikro ortamının düzenlenmesinde aktif bir rol oynar ve birçok kanser tipinde tanımlanmıştır. Buna karşın, mide kanseri açısından bu moleküllerle ilgili sınırlı sayıda çalışma vardır. Amaç: Çalışmamızda mide kanseri olgularında sPD-1, sOX40L ve sGITR düzeylerinin histopatolojik önemini belirlemeyi amaçladık. Gereç ve Yöntemler: Serum örnekleri 20 mide kanseri ve 34 sağlıklı kontrolün periferik kan örneklerinden elde edildi ve aday biyobelirteçlerin seviyeleri ELISA ile saptandı. Bulgular: sGITR düzeyi mide kanserli olgularda 48.28 ± 2.66 pg/mL ve control grubunda ise 39.19 ± 2.01 pg/ mL olarak tespit edildi (p = 0.014). sOX40 L düzeyi hasta larda 6.13 ± 0.64 pg/mL tespit edilirken, kontrolde 8.68 ± 0.99 pg/m olarak tespit edilmiştir. sOX40 L düzeyinin kontrol grubuna göre 1,41 kat yüksek olduğu saptanmıştır (p = 0.033). Taşlı yüzük hücreli karsinomlu olguların sGITR düzeylerinin diğer adenokarsinomalı gruptan yüksek olduğu tespit edilmiştir (p = 0.04). sPD-1düzeyi açısından ise gruplar arasında fark tespit edilmemiştir (p = 0.490).

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Horozoğlu C, SÖNMEZ D, KÜÇÜKHÜSEYİN Ö, DEMİRKOL Ş, Hakan M, arıkan s, Yaylim I (2021). The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. , 273 - 279. 10.1515/tjb-2020-0075
Chicago	Horozoğlu Cem,SÖNMEZ Dilara,KÜÇÜKHÜSEYİN Özlem,DEMİRKOL ŞEYDA,Hakan Mehmet Tolgahan,arıkan soykan,Yaylim Ilhan The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. (2021): 273 - 279. 10.1515/tjb-2020-0075
MLA	Horozoğlu Cem,SÖNMEZ Dilara,KÜÇÜKHÜSEYİN Özlem,DEMİRKOL ŞEYDA,Hakan Mehmet Tolgahan,arıkan soykan,Yaylim Ilhan The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. , 2021, ss.273 - 279. 10.1515/tjb-2020-0075
AMA	Horozoğlu C,SÖNMEZ D,KÜÇÜKHÜSEYİN Ö,DEMİRKOL Ş,Hakan M,arıkan s,Yaylim I The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. . 2021; 273 - 279. 10.1515/tjb-2020-0075
Vancouver	Horozoğlu C,SÖNMEZ D,KÜÇÜKHÜSEYİN Ö,DEMİRKOL Ş,Hakan M,arıkan s,Yaylim I The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. . 2021; 273 - 279. 10.1515/tjb-2020-0075
IEEE	Horozoğlu C,SÖNMEZ D,KÜÇÜKHÜSEYİN Ö,DEMİRKOL Ş,Hakan M,arıkan s,Yaylim I "The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer." , ss.273 - 279, 2021. 10.1515/tjb-2020-0075
ISNAD	Horozoğlu, Cem vd. "The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer". (2021), 273-279. https://doi.org/10.1515/tjb-2020-0075

APA	Horozoğlu C, SÖNMEZ D, KÜÇÜKHÜSEYİN Ö, DEMİRKOL Ş, Hakan M, arıkan s, Yaylim I (2021). The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. Türk Biyokimya Dergisi, 46(3), 273 - 279. 10.1515/tjb-2020-0075
Chicago	Horozoğlu Cem,SÖNMEZ Dilara,KÜÇÜKHÜSEYİN Özlem,DEMİRKOL ŞEYDA,Hakan Mehmet Tolgahan,arıkan soykan,Yaylim Ilhan The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. Türk Biyokimya Dergisi 46, no.3 (2021): 273 - 279. 10.1515/tjb-2020-0075
MLA	Horozoğlu Cem,SÖNMEZ Dilara,KÜÇÜKHÜSEYİN Özlem,DEMİRKOL ŞEYDA,Hakan Mehmet Tolgahan,arıkan soykan,Yaylim Ilhan The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. Türk Biyokimya Dergisi, vol.46, no.3, 2021, ss.273 - 279. 10.1515/tjb-2020-0075
AMA	Horozoğlu C,SÖNMEZ D,KÜÇÜKHÜSEYİN Ö,DEMİRKOL Ş,Hakan M,arıkan s,Yaylim I The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. Türk Biyokimya Dergisi. 2021; 46(3): 273 - 279. 10.1515/tjb-2020-0075
Vancouver	Horozoğlu C,SÖNMEZ D,KÜÇÜKHÜSEYİN Ö,DEMİRKOL Ş,Hakan M,arıkan s,Yaylim I The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer. Türk Biyokimya Dergisi. 2021; 46(3): 273 - 279. 10.1515/tjb-2020-0075
IEEE	Horozoğlu C,SÖNMEZ D,KÜÇÜKHÜSEYİN Ö,DEMİRKOL Ş,Hakan M,arıkan s,Yaylim I "The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer." Türk Biyokimya Dergisi, 46, ss.273 - 279, 2021. 10.1515/tjb-2020-0075
ISNAD	Horozoğlu, Cem vd. "The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer". Türk Biyokimya Dergisi 46/3 (2021), 273-279. https://doi.org/10.1515/tjb-2020-0075