TY  - JOUR
TI  - The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer
AB  - Objectives: Immunoregulatory GITR, OX40L and PD-1 molecules play an active role in the regulation of tumor microenvironment and have been shown in many can cer types. However, there are limited studies of these molecules in terms of gastric cancer. In our study, we aimed to determine the histopathological significance of sPD-1, sOX40L and sGITR levels in gastric cancer cases. Methods: Serum samples were obtained from peripheral blood samples of 20 gastric cancer and 34 healthy controls and candidate biomarker levels were determined by ELISA. Results: sGITR level was found to be 48.28 ± 2.66 pg/mL in the gastric cancers and 39.19 ± 2.01 pg/mL in the controls (p=0.014). sOX40L level was 6.13 ± 0.64 pg/mL in the pa tients and 8.68 ± 0.99 pg/mL in the control, and the sOX40L level was found to be 1.41 times higher in the control group compared to the patients (p=0.033). sGITR levels of signet-ring cell carcinoma were found to be higher than other adenocarcinomas (p=0.04). There was no dif ference between groups in sPD-1 (p=0.490). Conclusions: We suggest that sGITR, sOX40L and mole cules may play a role in tumor microenvironment regula tion and histological type in gastric cancer.
AU  - Horozoğlu, Cem
AU  - arıkan, soykan
AU  - KÜÇÜKHÜSEYİN, Özlem
AU  - DEMİRKOL, ŞEYDA
AU  - Hakan, Mehmet Tolgahan
AU  - SÖNMEZ, Dilara
AU  - Yaylim, Ilhan
DO  - 10.1515/tjb-2020-0075
PY  - 2021
JO  - Türk Biyokimya Dergisi
VL  - 46
IS  - 3
SN  - 1303-829X
SP  - 273
EP  - 279
DB  - TRDizin
UR  - http://search/yayin/detay/492540
ER  -