The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19
Yıl: 2021 Cilt: 46 Sayı: 2 Sayfa Aralığı: 157 - 166 Metin Dili: İngilizce DOI: 10.1515/tjb-2020-0359 İndeks Tarihi: 21-02-2022
The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19
Öz: Objectives: It is vital to determine the intensive care unit (ICU) requirement at an early stage to reduce the mortality rate in COVID-19 patients. The aim of the study was to find reliable predictive markers to determine the ICU requirement. Methods: We retrospectively reviewed the clinical and laboratory records of 151 COVID-19 patients. The predictive abilities of biochemical parameters and computed tomog raphy (CT) score were evaluated to determine of ICU requirement. Results: The area under curve (AUC) values for procalci tonin, D-Dimer, C reactive protein (CRP), glucose, lactate dehydrogenase (LDH) and CT score were found higher than those for other parameters in the prediction of ICU requi rement. The negative predictive values of these markers were higher than their positive predictive values. CT score was found to be highly correlated with fibrinogen and CRP. The glucose levels [odd ratio (OR): 95% CI; 1.07, p-value: 0.014] and CT score [OR: 95% CI; 1.05, p-value: 0.022] were associated with ICU requirement in COVID-19 patients. Conclusions: CT score, procalcitonin, D-Dimer, CRP, glucose, and LDH are potential predictors to rule out ICU requirement on hospital admission. Fibrinogen and CRP can be used to follow up and predict lung damages in patients with COVID-19.
Anahtar Kelime: COVID-19 hastalarinda laboratuvar parametreleri ve bilgisayarli tomografi skorunun yoğun bakim gereksiniminin belirlenmesinde kullanımı
Öz: Amaç: COVID-19 hastalarında ölüm oranını azaltmak için yoğun bakım ünitesi (YBÜ) ihtiyacınının erken dönemde belirlenmesi hayati önem taşır. Çalışmanın amacı, YBÜ gereksinimini belirlemek için güvenilir belirteçler bulmaktı. Gereç ve Yöntem: 151 COVID-19 hastasının klinik ve laboratuvar kayıtlarını geriye dönük olarak inceledik. Biyokimyasal parametrelerin ve bilgisayarlı tomografi (BT) skorunun YBÜ ihtiyacının belirlemesindeki tahmin gücü değerlendirildi. Bulgular: Yoğun bakım ünitesi gereksiniminin öngö rülmesinde prokalsitonin, D-Dimer, C reaktif protein (CRP), glukoz, laktat dehidrojenaz (LDH) ve BT skoru için eğri altı alan (AUC) değerleri diğer parametrelere göre daha yüksek bulundu. Bu belirteçlerin negatif tahmin değerleri, pozitif tahmin değerlerinden daha yüksekti. BT skorunun fibri nojen ve CRP ile yüksek oranda korelasyonlu olduğu bulundu. Glikoz seviyeleri [odd ratio (OR): CI 95%; 1.07, p-değeri: 0.014] ve CT skoru [OR: CI 95%; 1.05, p değeri: 0.022] COVID-19 hastalarında YBÜ gereksinimi ile ilişkilendirildi. Sonuç: CT skoru, prokalsitonin, D-Dimer, CRP, glukoz ve LDH, hastaneye yatışta YBÜ gereksinimini dışlamak için potansiyel prediktörlerdir. Fibrinojen ve CRP, COVID-19 hastalarında akciğer hasarlarını takip etmek ve tahmin etmek için kullanılabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | DOĞAN H, BOLAT S, BÜYÜKTUNA S, Sarıismailoğlu R, ÇETİNKAYA N, DOĞAN K, hasbek m, ÇAYLAK H (2021). The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. , 157 - 166. 10.1515/tjb-2020-0359 |
| Chicago | DOĞAN Halef Okan,BOLAT Serkan,BÜYÜKTUNA Seyit Ali,Sarıismailoğlu Rağıp,ÇETİNKAYA NAZIM,DOĞAN Kübra,hasbek mürşit,ÇAYLAK HALİL The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. (2021): 157 - 166. 10.1515/tjb-2020-0359 |
| MLA | DOĞAN Halef Okan,BOLAT Serkan,BÜYÜKTUNA Seyit Ali,Sarıismailoğlu Rağıp,ÇETİNKAYA NAZIM,DOĞAN Kübra,hasbek mürşit,ÇAYLAK HALİL The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. , 2021, ss.157 - 166. 10.1515/tjb-2020-0359 |
| AMA | DOĞAN H,BOLAT S,BÜYÜKTUNA S,Sarıismailoğlu R,ÇETİNKAYA N,DOĞAN K,hasbek m,ÇAYLAK H The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. . 2021; 157 - 166. 10.1515/tjb-2020-0359 |
| Vancouver | DOĞAN H,BOLAT S,BÜYÜKTUNA S,Sarıismailoğlu R,ÇETİNKAYA N,DOĞAN K,hasbek m,ÇAYLAK H The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. . 2021; 157 - 166. 10.1515/tjb-2020-0359 |
| IEEE | DOĞAN H,BOLAT S,BÜYÜKTUNA S,Sarıismailoğlu R,ÇETİNKAYA N,DOĞAN K,hasbek m,ÇAYLAK H "The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19." , ss.157 - 166, 2021. 10.1515/tjb-2020-0359 |
| ISNAD | DOĞAN, Halef Okan vd. "The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19". (2021), 157-166. https://doi.org/10.1515/tjb-2020-0359 |
| APA | DOĞAN H, BOLAT S, BÜYÜKTUNA S, Sarıismailoğlu R, ÇETİNKAYA N, DOĞAN K, hasbek m, ÇAYLAK H (2021). The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. Türk Biyokimya Dergisi, 46(2), 157 - 166. 10.1515/tjb-2020-0359 |
| Chicago | DOĞAN Halef Okan,BOLAT Serkan,BÜYÜKTUNA Seyit Ali,Sarıismailoğlu Rağıp,ÇETİNKAYA NAZIM,DOĞAN Kübra,hasbek mürşit,ÇAYLAK HALİL The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. Türk Biyokimya Dergisi 46, no.2 (2021): 157 - 166. 10.1515/tjb-2020-0359 |
| MLA | DOĞAN Halef Okan,BOLAT Serkan,BÜYÜKTUNA Seyit Ali,Sarıismailoğlu Rağıp,ÇETİNKAYA NAZIM,DOĞAN Kübra,hasbek mürşit,ÇAYLAK HALİL The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. Türk Biyokimya Dergisi, vol.46, no.2, 2021, ss.157 - 166. 10.1515/tjb-2020-0359 |
| AMA | DOĞAN H,BOLAT S,BÜYÜKTUNA S,Sarıismailoğlu R,ÇETİNKAYA N,DOĞAN K,hasbek m,ÇAYLAK H The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. Türk Biyokimya Dergisi. 2021; 46(2): 157 - 166. 10.1515/tjb-2020-0359 |
| Vancouver | DOĞAN H,BOLAT S,BÜYÜKTUNA S,Sarıismailoğlu R,ÇETİNKAYA N,DOĞAN K,hasbek m,ÇAYLAK H The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19. Türk Biyokimya Dergisi. 2021; 46(2): 157 - 166. 10.1515/tjb-2020-0359 |
| IEEE | DOĞAN H,BOLAT S,BÜYÜKTUNA S,Sarıismailoğlu R,ÇETİNKAYA N,DOĞAN K,hasbek m,ÇAYLAK H "The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19." Türk Biyokimya Dergisi, 46, ss.157 - 166, 2021. 10.1515/tjb-2020-0359 |
| ISNAD | DOĞAN, Halef Okan vd. "The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19". Türk Biyokimya Dergisi 46/2 (2021), 157-166. https://doi.org/10.1515/tjb-2020-0359 |
