TY  - JOUR
TI  - The role of the delta neutrophil index in determining the etiology of neonatal sepsis
AB  - Objectives: To demonstrate immature granulocyte (IG) count and delta neutrophil index (DNI) values (novel po tential predictive marker for neonatal sepsis) for neonates. Methods: This prospective controlled clinical study was con sisted of 208 patients (77 in the study group and 131 in the control group) who were delivered between January 2016 and January 2018 at the Hacettepe University Neonatal Intensive CareUnitinAnkara, Turkey. In this study, we evaluated value of DNIin diagnosing neonatal sepsis by comparing the DNI values in culture positive septic neonates with healthy neonates. Results: In our study, the median interquartile range (IQR = 25–75%) DNI was 0.1% (0.0–0.3%) in the control group and 1.5% (1.0–2.45%) in the sepsis group (p < 0.05). In our ROC curve analysis, the cut-off value for the DNI as a sepsis marker was 0.65%, with 96.2% specificity and 97.4% sensitivity. Those patients with gram-negative isolates had significantly higher DNI and IG counts when compared to those patients with gram-positive bacteria (p < 0.05). Conclusions: Our findings indicated that the DNI counts are significant diagnostic biomarkers for neonatal sepsis. They may also have utility in determining the sepsis eti ology (differentiating between gram-positive and gram negative agents).
AU  - SANCAK, Banu
AU  - YURDAKÖK, Murat
AU  - ÇELİK, Hasan Tolga
AU  - PORTAKAL, Oytun
AU  - BÜYÜKEREN, MELEK
AU  - yigit, sule
DO  - 10.1515/tjb-2020-0030
PY  - 2021
JO  - Türk Biyokimya Dergisi
VL  - 46
IS  - 1
SN  - 1303-829X
SP  - 73
EP  - 79
DB  - TRDizin
UR  - http://search/yayin/detay/492708
ER  -