TY  - JOUR
TI  - Immature platelet fraction: is a novel early predictive marker for disease severity in patients with Covid-19 pneumonia?
AB  - Objectives: In many diseases, immature platelet fraction (IPF%) is related to coagulopathy and poor outcome. This study aimed to investigate the predictive value of IPF% for the severity of pneumonia in patients with Coronavirus Disease 2019 (COVID-19). Methods: A total of 154 patients with COVID‐19 infections were included. The patients were divided into two groups according to the severity of pneumonia (severe and non severe) regarding their oxygen demand. Results: Given laboratory parameters, the median IPF% was significantly higher in the severe group (11.9 vs. 3.9%, p<0.001). Mean platelet volume (p<0.001), platelet-large cell ratio (p=0.001), platelet distribution width (p=0.001), D-Dimer (p<0.001), INR (p=0.003), and aPTT (p=0.007) were also found to be significantly higher in the severe group. Moreover, IPF (p=0.014, Odds ratio = 2.000, 95%CI: 1.149-3.482) was an independent predictor for the severity. The curve value from receiver operating characteristics was 0.879 (p<0.001, 95%CI: 0.784-0.943) for determining the severity of pneumonia. IPF% had a sensitivity and specificity value of 69.5 and 92.4% to detect the disease’s severity. Conclusions: IPF% is an independent predictor for the severity of COVID-19 pneumonia. Assessment of IPF% may both help to early determine high-risk patients with COVID-19 and to alert the physicians.
AU  - PALOĞLU, Kerim Erhan
AU  - KANT, Hatice
AU  - OKAN, Ayşe
AU  - Kapmaz, Mahir
AU  - DAĞEL, Tuncay
AU  - Baygül, Arzu
AU  - Akpinar, Timur
AU  - İncir, Said
AU  - TEKİN, Suda
AU  - KÖMEŞLİ, Zeynep
AU  - Somay, Kayra
AU  - Atam Taşdemir, Zeynep
AU  - Kilic, Alparslan
DO  - 10.1515/tjb-2021-0070
PY  - 2021
JO  - Türk Biyokimya Dergisi
VL  - 46
IS  - 4
SN  - 1303-829X
SP  - 359
EP  - 366
DB  - TRDizin
UR  - http://search/yayin/detay/492749
ER  -