TY  - JOUR
TI  - Gastrointestinal Symptoms and Liver Damage inPatients with COVID-19
AB  - Introduction: Gastrointestinal and hepatic symptoms may be seen before respiratory symptoms in Coronavirus disease 2019 (COVID 19). The purpose of the present study was to evaluate the relationship between liver damage and observed symptoms and laboratoryparameters. Materials and Methods: Patients followed-up with diagnoses of COVID-19 between March and August 2020 were included in thestudy. Clinical characteristics and laboratory parameters were compared according to liver damage status. Results: Four hundred and thirteen COVID-19 cases were included. The prevalence of gastrointestinal symptoms was 19.8%, the mostcommon being nausea/vomiting, abdominal pain, and diarrhea (10.4%, 6.1%, and 2.9%, respectively). CT-confirmed pneumonia,intensive care requirement, and mean length of hospitalization differed significantly depending on liver damage status (p< 0.001, p=0.006, p= 0.002, respectively). Significant differences were determined between the groups with and without liver damage in terms ofall the laboratory parameters examined, apart from white blood cell, neutrophil, lymphocyte, neutrophil:lymphocyte ratio (NLR), totalbilirubin, and partial thromboplastin time (PTT) (p< 0.05). Significant associations were present between alanine aminotransferase lev els and all other laboratory parameters apart from NLR and PTT (p< 0.001). Aspartate aminotransferase (OR: 1.22, CI: 1.16-1.28) andalbumin (OR: 2.28, CI: 1.12-4.63) were identified as significant independent risk factors for liver damage in patients with COVID-19. Conclusion: Gastrointestinal symptoms are not uncommon in COVID-19 patients. Liver damage may be associated with progressionto intensive care and systemic inflammation.
AU  - YILMAZ, Sinan
AU  - ÖZKURT, Zülal
AU  - CAN, Fatma KESMEZ
AU  - PARLAK, Emine
AU  - OZDEN, KEMALETTIN
AU  - ALBAYRAK, AYŞE
AU  - TEKİN, Erdal
AU  - KOÇAK, Abdullah Osman
AU  - Alay, Handan
DO  - 10.5578/flora.20219801
PY  - 2021
JO  - Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
VL  - 26
IS  - 2
SN  - 1300-932X
SP  - 249
EP  - 256
DB  - TRDizin
UR  - http://search/yayin/detay/492838
ER  -