The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model

BEKTAŞ, Çağlar; Elmas, Cigdem; AKTAŞ, Zeynep; dilekmen, nilay; Atalay, Hatice Tuba; SEYMEN, Cemile Merve

doi:10.37844/glauc.cat.2021.16.21

The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model

Çağlar BEKTAŞ, (Çan Devlet Hastanesi, Göz Hastalıkları Anabilim Dalı, Çanakkale, Türkiye)

Hatice Tuba ATALAY, (Gazi Üniversitesi,Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Cemile Merve SEYMEN, (Gazi Üniversitesi, Histoloji ve Embriyoloji Anabilim Dalı, Ankara ,Türkiye)

Nilay DİLEKMEN, (Palandöken Devlet Hastanesi, Göz Hastalıkları Anabilim Dalı, Erzurum, Türkiye)

Zeynep AKTAŞ, (Gazi Üniversitesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Çiğdem ELMAS (Gazi Üniversitesi, Histoloji ve Embriyoloji Anabilim Dalı, Ankara, Türkiye)

Glokom Katarakt

6 0

Yıl: 2021 Cilt: 16 Sayı: 2 Sayfa Aralığı: 122 - 128 Metin Dili: İngilizce DOI: 10.37844/glauc.cat.2021.16.21 İndeks Tarihi: 21-02-2022

The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model

Öz:

Purpose: To investigate the wound healing effect of topical and subconjunctival Coenzyme Q10 (CoQ) in an experimental trabeculectomy model, and to compare the outcomes with mitomycin C and bevacizumab. Materials and Methods: Thirty eyes of 27 Wistar Albino rats were included. Group 1 was the control group and the other four groups were mitomycin C (group 2), topical CoQ (group 3), subconjunctival CoQ (group 4), and bevacizumab (group 5). Conjunctival and scleral incisions were made to mimic the trabeculectomy wound. After the rats were sacrifi ced, histological sections were examined for vasculogenesis, VEGF and TGF-β1 positivity. Results: The mean vascularization score was lowest in groups 3 and 4 (0.5±0.55). It was followed by group 2 (1.0± 0.89), group 5 (1.5±1.0), and control group (2.5±0.55). The eyes in group 2, 3 and 4 showed signifi cantly less vascularization than the control group (p = 0.015, p <0.01, p <0.01). VEGF and TGF-β1 positivity scores were lowest in groups 3 and 4 (1.48±0.45). This was followed by group 2 (2.0±0.34), group 5 (3.5±0.3), and control group (3.94±0.5). TGF-β1 and VEGF positive cells were signifi cantly lower in groups 2, 3 and 4 than group 1 (p <0.01). TGF-β1 and VEGF positivity in groups 3 and 4 were signifi cantly lower than the group 2 (p = 0.04). Conclusion: The application of topical and subconjunctival CoQ resulted in inhibition of vasculogenesis and reduction of TGF-β1 and VEGFpositive cells in trabeculectomy wound healing model. Topical or subconjunctival application of CoQ in trabeculectomy surgery may provide positive effects on wound healing..

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	BEKTAŞ Ç, Atalay H, SEYMEN C, dilekmen n, AKTAŞ Z, Elmas C (2021). The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. , 122 - 128. 10.37844/glauc.cat.2021.16.21
Chicago	BEKTAŞ Çağlar,Atalay Hatice Tuba,SEYMEN Cemile Merve,dilekmen nilay,AKTAŞ Zeynep,Elmas Cigdem The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. (2021): 122 - 128. 10.37844/glauc.cat.2021.16.21
MLA	BEKTAŞ Çağlar,Atalay Hatice Tuba,SEYMEN Cemile Merve,dilekmen nilay,AKTAŞ Zeynep,Elmas Cigdem The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. , 2021, ss.122 - 128. 10.37844/glauc.cat.2021.16.21
AMA	BEKTAŞ Ç,Atalay H,SEYMEN C,dilekmen n,AKTAŞ Z,Elmas C The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. . 2021; 122 - 128. 10.37844/glauc.cat.2021.16.21
Vancouver	BEKTAŞ Ç,Atalay H,SEYMEN C,dilekmen n,AKTAŞ Z,Elmas C The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. . 2021; 122 - 128. 10.37844/glauc.cat.2021.16.21
IEEE	BEKTAŞ Ç,Atalay H,SEYMEN C,dilekmen n,AKTAŞ Z,Elmas C "The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model." , ss.122 - 128, 2021. 10.37844/glauc.cat.2021.16.21
ISNAD	BEKTAŞ, Çağlar vd. "The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model". (2021), 122-128. https://doi.org/10.37844/glauc.cat.2021.16.21

APA	BEKTAŞ Ç, Atalay H, SEYMEN C, dilekmen n, AKTAŞ Z, Elmas C (2021). The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. Glokom Katarakt, 16(2), 122 - 128. 10.37844/glauc.cat.2021.16.21
Chicago	BEKTAŞ Çağlar,Atalay Hatice Tuba,SEYMEN Cemile Merve,dilekmen nilay,AKTAŞ Zeynep,Elmas Cigdem The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. Glokom Katarakt 16, no.2 (2021): 122 - 128. 10.37844/glauc.cat.2021.16.21
MLA	BEKTAŞ Çağlar,Atalay Hatice Tuba,SEYMEN Cemile Merve,dilekmen nilay,AKTAŞ Zeynep,Elmas Cigdem The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. Glokom Katarakt, vol.16, no.2, 2021, ss.122 - 128. 10.37844/glauc.cat.2021.16.21
AMA	BEKTAŞ Ç,Atalay H,SEYMEN C,dilekmen n,AKTAŞ Z,Elmas C The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. Glokom Katarakt. 2021; 16(2): 122 - 128. 10.37844/glauc.cat.2021.16.21
Vancouver	BEKTAŞ Ç,Atalay H,SEYMEN C,dilekmen n,AKTAŞ Z,Elmas C The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. Glokom Katarakt. 2021; 16(2): 122 - 128. 10.37844/glauc.cat.2021.16.21
IEEE	BEKTAŞ Ç,Atalay H,SEYMEN C,dilekmen n,AKTAŞ Z,Elmas C "The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model." Glokom Katarakt, 16, ss.122 - 128, 2021. 10.37844/glauc.cat.2021.16.21
ISNAD	BEKTAŞ, Çağlar vd. "The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model". Glokom Katarakt 16/2 (2021), 122-128. https://doi.org/10.37844/glauc.cat.2021.16.21