The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats

EKICI, MEHMET

doi:10.47027/duvetfd.839345

The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats

Mehmet EKİCİ (Sivas Cumhuriyet Üniversitesi, Veteriner Fakültesi, Veteriner Fizyolojisi Anabilim Dalı, Sivas, Türkiye)

Dicle Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2021 Cilt: 14 Sayı: 1 Sayfa Aralığı: 31 - 34 Metin Dili: İngilizce DOI: 10.47027/duvetfd.839345 İndeks Tarihi: 29-07-2022

The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats

Öz:

This study investigates changes in systolic and diastolic blood pressure in Sprague Dawley rat dams exposed to postpartum stress. Eighteen pregnant dams were randomly divided into three groups: Control (C, n = 6, no-stress), Maternal Separation (MS, n = 6), and Brief Maternal Separation (BMS, n = 6). The dams and pups in group C were housed under standard conditions in their cages at the animal facility during the postpartum period. From postpartum day 2 to day 14, the dams and pups in group MS and BMS were separated from each other every day for 3-h and 15-min, respectively. Systolic and diastolic blood pressures of the dams were recorded on postpartum days 2, 8, and 14 by tail-cuff method. The findings show that the 3-h dam-pup separation caused high systolic blood pressure in dams, compared to the control dams at all time points that blood pressure was recorded (p<0.001). However, this effect is significant only on postpartum days 2 (p<0.01) and 8 (p<0.001) when compared to the dams that were subjected to 15-min separation. In addition, the 3-h and 15-min dam-pup separations lead to high diastolic blood pressure when compared to the controls throughout the experiment. The 3-h separation caused high diastolic blood pressure only on day 2, when compared to the dams that were subjected to the 15-min pup separation (p<0.01). The obtained data indicate that postpartum dam-pup separation may lead to an increase in blood pressure in Sprague-Dawley rats.

Anahtar Kelime: maternal separation Blood pressure pup

Sprague Dawley Sıçanlarında Anne-Yavru Ayrılmasının Maternal Sistolik ve Diyastolik Kan Basıncı Üzerine Etkisi

Öz:

Bu çalışma, doğum sonrası erken yaşam stresine maruz kalan Sprague Dawley anne sıçanlarda sistolik ve diyastolik kan basıncındaki değişiklikleri araştırmaktadır. On sekiz gebe sıçan rastgele Kontrol (K, n: 6), Anne ayırma (AA, n: 6) ve Kısa Anne Ayırma (KAA, n: 6) gruplarına ayrıldı. Grup K'de (ellenmemiş), anne sıçanlar ve yavrular postnatal 2-14 gün boyunca standart hayvan yetiştirme koşulları altında rahatsız edilmeden barındırıldı. AA grubunda anne sıçanlar ve yavrular postnatal 2. ve 14. günlerde her gün 3 saat birbirinden ayrıldı. Grup KAA'da anne sıçanlar ve yavrular postnatal 2. ve 14. günlerde her gün 15 dk birbirinden ayrıldı. Anne sıçanların sistolik ve diyastolik kan basınçları postnatal 2., 8. ve 14. günlerde tail-cuff yöntemi ile kaydedildi. AA grubunda sistolik kan basıncı tüm postnatal günlerde K grubuna göre daha yüksekti (p<0.001). KAA grubundaki sistolik kan basıncı postnatal 2. ve 8. günde AA grubuna göre sırasıyla daha düşüktü (p<0.01, p<0.001). Ancak postnatal 14. günde AA grubu ile KAA grupları arasında fark yoktu (p>0.05). Diyastolik kan basıncı AA grubunda doğum sonrası tüm günlerde K grubuna göre daha yüksekti (p<0.001, p<0.01, p<0.001). Benzer şekilde doğum sonrası tüm günlerde KAA grubu K grubundan yüksekti (p<0.001, p<0.05, p<0.01). Postnatal 2. günde KAA grubunun diyastolik kan basıncı AA grubuna göre sırasıyla daha düşüktü (p<0.01). Ancak AA grubu ile KAA grupları arasında postnatal 8. ve 14. günlerde fark yoktu (p>0.05). Sonuç olarak, erken yaşam stresi Sprague-Dawley anne sıçanlarda kan basıncını artırabilir.

Anahtar Kelime: rat

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	EKICI M (2021). The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. , 31 - 34. 10.47027/duvetfd.839345
Chicago	EKICI MEHMET The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. (2021): 31 - 34. 10.47027/duvetfd.839345
MLA	EKICI MEHMET The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. , 2021, ss.31 - 34. 10.47027/duvetfd.839345
AMA	EKICI M The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. . 2021; 31 - 34. 10.47027/duvetfd.839345
Vancouver	EKICI M The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. . 2021; 31 - 34. 10.47027/duvetfd.839345
IEEE	EKICI M "The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats." , ss.31 - 34, 2021. 10.47027/duvetfd.839345
ISNAD	EKICI, MEHMET. "The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats". (2021), 31-34. https://doi.org/10.47027/duvetfd.839345

APA	EKICI M (2021). The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 14(1), 31 - 34. 10.47027/duvetfd.839345
Chicago	EKICI MEHMET The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. Dicle Üniversitesi Veteriner Fakültesi Dergisi 14, no.1 (2021): 31 - 34. 10.47027/duvetfd.839345
MLA	EKICI MEHMET The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. Dicle Üniversitesi Veteriner Fakültesi Dergisi, vol.14, no.1, 2021, ss.31 - 34. 10.47027/duvetfd.839345
AMA	EKICI M The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2021; 14(1): 31 - 34. 10.47027/duvetfd.839345
Vancouver	EKICI M The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2021; 14(1): 31 - 34. 10.47027/duvetfd.839345
IEEE	EKICI M "The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats." Dicle Üniversitesi Veteriner Fakültesi Dergisi, 14, ss.31 - 34, 2021. 10.47027/duvetfd.839345
ISNAD	EKICI, MEHMET. "The Effect of Maternal-Pup Separation on Maternal Systolic and Diastolic Blood Pressure in Spra-gue Dawley Rats". Dicle Üniversitesi Veteriner Fakültesi Dergisi 14/1 (2021), 31-34. https://doi.org/10.47027/duvetfd.839345